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MSDS  : Phosphoric acid, triphenyl ester
CAS  : 115-86-6
SYNONYMS  : * Celluflex TPP * Disflamoll TP * Phosflex TPP * TPP * Trifenylfosfat * Triphenyl phosphate
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : TC8400000
CHEMICAL NAME : Phosphoric acid, triphenyl ester
CAS REGISTRY NUMBER : 115-86-6
BEILSTEIN REFERENCE NO. : 1888236
REFERENCE : 4-06-00-00720 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 51
MOLECULAR FORMULA : C18-H15-O4-P
MOLECULAR WEIGHT : 326.30
WISWESSER LINE NOTATION : ROPO&OR&OR
SYNONYMS/TRADE NAMES :
* Celluflex TPP
* Disflamoll TP
* Phosflex TPP
* TPP
* Trifenylfosfat
* Triphenyl phosphate

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3500 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - ataxia
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 7,585,1957

TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535042

TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 1,33,1960

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1320 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - somnolence (general depressed activity)
Behavioral - changes in motor activity (specific assay)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 39(8),98,1974

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1273 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050,
Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
Volume(issue)/page/year: 31,1288,1967

TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 1,33,1960

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
4,420,1980

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - tremor
Behavioral - muscle weakness
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 7,585,1957

TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : >400 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory
change
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 1,33,1960

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - tremor
Behavioral - muscle weakness
REFERENCE :
NIHBAZ National Institutes of Health, Bulletin. (Bethesda, MD)
Volume(issue)/page/year: 160,1,1932

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 1,33,1960

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >7900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
41,291,1977

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 1,33,1960

TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIHBAZ National Institutes of Health, Bulletin. (Bethesda, MD)
Volume(issue)/page/year: 160,1,1932

TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : >4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 1,33,1960

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : >4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
Volume(issue)/page/year: 21MAY1971

TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : >3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 1,33,1960

TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIHBAZ National Institutes of Health, Bulletin. (Bethesda, MD)
Volume(issue)/page/year: 160,1,1932

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 4200 mg/m3
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - somnolence (general depressed activity)
Behavioral - changes in motor activity (specific assay)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 39(8),98,1974

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 65 gm/kg/65D-C
TOXIC EFFECTS :
Spinal Cord - other degenerative changes
Peripheral Nerve and Sensation - sensory syndrome diagnostic of central
lesion
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 7,585,1957

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 59353 mg/kg/35D-C
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 1,33,1960

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 600 mg/kg/10D-I
TOXIC EFFECTS :
Behavioral - tremor
Nutritional and Gross Metabolic - other changes
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 7,585,1957

*** REVIEWS ***

ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

ACGIH TLV-TWA 3 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

TOXICOLOGY REVIEW
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate
Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year:
3,289,1975

*** U.S. STANDARDS AND REGULATIONS ***

MSHA STANDARD-air:TWA 3 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,272,1971

OSHA PEL (Gen Indu):8H TWA 3 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994

OSHA PEL (Construc):8H TWA 3 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 3 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993

OSHA PEL (Fed Cont):8H TWA 3 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-AUSTRALIA:TWA 3 mg/m3 JAN 1993

OEL-BELGIUM:TWA 3 mg/m3 JAN 1993

OEL-DENMARK:TWA 3 mg/m3 JAN 1993

OEL-FINLAND:TWA 3 mg/m3;STEL 6 mg/m3;Skin JAN 1993

OEL-FRANCE:TWA 3 mg/m3 JAN 1993

OEL-THE NETHERLANDS:TWA 3 mg/m3 JAN 1993

OEL-RUSSIA:STEL 1 mg/m3 JAN 1993

OEL-SWITZERLAND:TWA 3 mg/m3 JAN 1993

OEL-UNITED KINGDOM:TWA 3 mg/m3;STEL 6 mg/m3 JAN 1993

OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO TRIPHENYL PHOSPHATE-air:10H TWA 3 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 74635
No. of Facilities: 341 (estimated)
No. of Industries: 11
No. of Occupations: 30
No. of Employees: 7631 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 74635
No. of Facilities: 2869 (estimated)
No. of Industries: 51
No. of Occupations: 54
No. of Employees: 91754 (estimated)
No. of Female Employees: 22800 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
47,26992,82

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9169;8EHQ-0892-8839

EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9290

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NIOSH Analytical Method, 1994: Triphenyl phosphate, 5038


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Phosphoric acid, monoethyl ester, compd. with2-ethyl-2-thiopseudourea (1:1) 21704-45-0
Phosphoric acid, mono(2-ethylhexyl) ester 1070-03-7
Phosphoric acid, monolithium salt 13453-80-0
Phosphoric acid, monomethyl ester 812-00-0
Phosphoric acid, mono(1-methylethyl) monophenyl ester 46355-07-1
Phosphoric acid, monomethyl mono(4-nitro-m-tolyl)ester 15930-84-4
Phosphoric acid, mono(2-methylphenyl) ester, disodiumsalt 15930-84-4
Phosphoric acid, monooctyl ester 3991-73-9
Phosphoric acid, monopotassium salt 7778-77-0
Phosphonothioic acid, methyl-, O-cyclohexylS-(2-(diethylamino)ethyl ester 71293-89-5
Phosphoric acid, monopropyl ester 1623-06-9
Phosphoric acid, nickel chromium salt 1623-06-9
Phosphoric acid, 4-nonylphenyl diphenyl ester mixedwith 4-(1-methylethyl) phenyl diphenylphosphate 1623-06-9
Phosphoric acid, pentyl ester 12789-46-7
Phosphoric acid, 1,3-phenylene tetraphenyl ester 57583-54-7
Phosphoric acid, sodium salt 7632-05-5
Phosphoric acid, strontium salt 14414-90-5
Phosphoric acid,2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxopurin-7-yl) ethyl cyclic 2,2-dimethyltrimethylene ester 69387-75-3
Phosphoric acid,2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxopurin-7-yl) ethyl cyclic trimethylene ester 69387-74-2
Phosphoric acid, tin(2+) salt (11) 16834-09-6
Phosphonothioic acid, methyl-, O-cyclopentyl S-methylester, (-)- 65167-60-4
Phosphoric acid, titanium(IV) salt 17017-57-1
Phosphoric acid, trianhydride with ethyl hydrogenphenylphosphonate 64058-56-6
Phosphoric acid, tributyl ester 126-73-8
Phosphoric acid, triethyl ester 78-40-0
Phosphoric acid, trimethyl ester 512-56-1
Phosphoric acid, triphenyl ester 115-86-6
Phosphoric acid, tripotassium salt 7778-53-2
Phosphoric acid, tri-2-propenyl ester 1623-19-4
Phosphoric acid, tris(2-bromo-1-chloro-2-propyl)ester 7328-28-1
Phosphoric acid, tris(tert-butylphenyl) ester 28777-70-0
Phosphonothioic acid, methyl-, O-cyclopentyl S-methylester, (+)- 65167-59-1
Phosphoric acid, tris(2-chlorobutyl) ester 73972-80-2
Phosphoric acid, tris(2-chloro-1-methylethyl) ester 13674-84-5
Phosphoric acid, tris(1-cyanobutyl) ester 73972-81-3
Phosphoric acid, tris(2,3-dibromobutyl)- 111712-47-1
Phosphoric acid, tris(3,4-dibromo-2-butyl)- 111712-45-9
Phosphoric acid, tris(2-methylallyl)- 14019-81-9
Phosphoric acid, tris(2-methylpropyl) ester 126-71-6
Phosphoric acid, trisodium salt 7601-54-9
Phosphoric acid, trisodium salt, dodecahydrate 10101-89-0
Phosphoric acid, tris(pentachlorophenyl) ester 4062-20-8
Phosphonothioic acid, methyl-, O-cyclopentyl S-propylester, (-)- 65167-62-6
Phosphoric acid,tris(2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxopurin-7-yl)ethyl) ester 65167-62-6
Phosphoric acid, tris(trimethylsilyl) ester 10497-05-9
Phosphoric acid, tritolyl ester 1330-78-5
Phosphoric acid, tri-o-tolyl ester 78-30-8
Phosphoric acid, 3,5-xylyl ester 39289-88-8
Phosphoric acid, zinc salt (23) 7779-90-0
Phosphoric acid, zinc salt (21), dihydrate 13598-37-3

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