ing 2: of m-tmxdi vapor for 6 hrs/day, 5 days/wk. severe ing 3:0.7 & at 1.5 ppm starting second week of expos. one ing 4: lung injury and mortality occurred in rats only at ing 5: than in rats because mice inhaled more m-tmxdi than ing 6: to min histologic changes in nasal passages due to ing 7: when applied to skin of guinea pigs. other ing 8:significant irrit of resp airways, however, lab ing 9: in guinea pigs. cynamid has sponsored a clinical ing 10: exposed to m-tmxdi for over 3 yrs. irrit symps were ing 11: mediated disease was found. spill proc: some inert absorbent matl; sweep up & place in hygiene prac: drinking/smoking wash face & hands w/soap & benzene, 1,3-bis(1-isocyanato-1-methylethyl)-; efts of overexp: irrit eft of m-tmxdi expos. in 90-day
LD50 LC50 Mixture:LD50: (ORAL, RAT) >5,000 MG/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:NO
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:DIRECT CONTACT W/THIS MATERIAL CAN
CAUSE MODERATE SKIN & MILD EYE IRRIT. REPEATED OR PROLONGED DERM
CONTACT W/MATL MAY CAUSE ALLERGIC SKIN REACTIONS. INHALATION
OVEREXPOSURE MAY CAUSE IRRITATION OF RE SPIRATORY TRACT AND EYES.
MOD SKIN IRRIT & MILD EYE IRRIT WERE PRDCED DURING PRIMARY IRRIT
STUDIES W/(EFTS OF OVEREXP)
Explanation of Carcinogenicity:NOT RELEVANT.
Effects of Overexposure:HLTH HAZ: RABBITS. IN 28-DAY INHAL STUDY, RATS
WERE EXPOSED TO 0.5, 1.5/5.0 MG/M3 M-TMXDI AEROSOL FOR 6 HRS/DAY, 5
DAYS/WK. EFTS WERE NOTED AT HIGH DOSE LEVEL & INCLD DECREASED BODY
WEIGHT, INCREASED LUNG WEIGHT, LUNG DISCOLORATION & INFLAMM &
HYPERPLASTIC & METAPLASTIC CHANGES OF BRONCHI THAT WERE ATTRIBUTED
TO(ING 2)
Medical Cond Aggravated by Exposure:NONE SPECIFIED BY MANUFACTURER.
======================= First Aid Measures =======================
First Aid:SKIN:IMMED WASH AFFECTED AREAS W/SOAP & PLENTY OF WATER.
REMOVE CONTAMD CLTHG & SHOES. OBTAIN MD ATTN. DESTROY/THORO CLEAN
SHOES BEFORE REUSE. DO NOT REUSE CONTAMD CLTHG W/OUT LAUNDERING.
EYE:IMMED IR RIGATE W/PLENTY OF WATER FOR AT LEAST 15 MINS.
INHAL:REMOVE FROM EXPOS. ADMN O*2 IF THERE IS DFCLTY IN BRTHG. GIVE
ARTF RESP IF PERS IS NOT BRTHG & CONTINUE UNTIL NORM BRTHG IS
ESTAB. OBTAIN (SUPDAT)
===================== Fire Fighting Measures =====================
Flash Point Method:SCC
Flash Point:308F,153C
Extinguishing Media:USE CARBON DIOXIDE, DRY CHEM, WATER SPRAY/ALCOHOL
FOAM TO EXTING FIRES. IF WATER SPRAY/ALCOHOL FOAM IS USED,
IT(SUPDAT)
Fire Fighting Procedures:WEAR NIOSH/MSHA APPRVD SCBA & FULL PROT EQUIP.
USE WATER TO KEEP FIRE-EXPOSED CNTNRS COOL.
Unusual Fire/Explosion Hazard:DO NOT RESEAL CONTAMINATED CONTAINERS
SINCE PRESSURE BUILD-UP MAY CAUSE RUPTURE.
Spill Release Procedures:WHERE EXPOS LEVEL IS NOT KNOWN, WEAR
NIOSH/MSHA APPRVD POSITIVE PRESS SELF-CNTND RESP. WHERE EXPOS LEVEL
IS KNOWN, WEAR NIOSH/MSHA APPRVD RESP SUITABLE FOR LEVEL OF EXPOS.
IN ADDTN TO PROT CLTHG/EQUIP , WEAR IMPERVIOUS BOOTS. COVER SPILLS
W/(ING 13)
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.
====================== Handling and Storage ======================
Handling and Storage Precautions:AVOID BREATHING DUST/VAPOR. AVOID
CONTACT W/EYES, SKIN & CLTHG. KEEP CNTNR CLSD. USE W/ADEQ VENT. DO
NOT ALLOW WATER/OTHER LIQUIDS TO GET INTO CNTNR.
Other Precautions:DO NOT HEAT CONTENTS IN CLOSED CNTNR. THE 1-HOUR
AEROSOL LC50 VALUE OF THIS MATL IS UNLIKELY TO BE ENCOUNTERED UNDER
REASONABLY FORSEEABLE TRANSPORT CNDTNS BECAUSE OF ITS VERY LOW
VOLATILITY.
Respiratory Protection:WHERE EXPOS ARE BELOW PEL, NO RESP PROT IS REQD.
WHERE EXPOS EXCEED PEL, USE RESP APPRVD BY NIOSH/MSHA APPRVD BY
NIOSH/MSHA FOR MATL & LEVEL OF EXPOS. SEE "GUIDE TO INDUSTRIAL
RESPIRATORY PROTECTION" (NIOSH).
Ventilation:WHERE THIS MATL IS NOT USED IN CLSD SYS, GOOD ENCLOSURE &
LOC EXHST VENT SHOULD BE PROVIDED TO CONTROL EXPOSURE.
Protective Gloves:IMPERVIOUS GLOVES.
Eye Protection:ANSI APPRVD CHEM WORKERS GOGGS.
Other Protective Equipment:ANSI APPRVD EMER EYEWASH & DELUGE SHOWER.
IMPERVIOUS APRON, WORKPANTS, LONG SLEEVE, WORK SHIRT/DISP
COVERALLS.
Work Hygienic Practices:FOOD, BEVERAGES & TOBACCO PRODS SHOULD NOT BE
CARRIED, STORED/CONSUMED WHERE MATL IS IN USE. BEFORE EATING, (ING
14)
Supplemental Safety and Health
EXTING MEDIA: SHOULD BE IN LGE QTYS. WATER/ALCOHOL FOAM MAY REACT
VIGOROUSLY W/HOT ISOCYANATE RELEASING CARBON DIOXIDE.
CNDTNS(POLYM): OF HEAT & CARBON DIOXIDE. FIRST AID PROC: MED ATTN
W/OUT DELAY. I NGEST: CALL MD IMMED. HYGIENE PRAC:DRINKING/SMOKING
WASH FACE & HANDS W/SOAP & WATER. AVOID SKIN CONTACT.
Waste Disposal Methods:DISPOSE OF IN ACCORDANCE W/APPLICABLE LOCAL,
STATE & FEDERAL REGULATIONS.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.