=====================  Product Identification  =====================

MSDS NAME:65300 THEOPHYLLINE 200 MG
NIIN:00F052796
MSDS Number: CDCDD
=== Responsible Party ===
Company:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Info Phone Num:301-881-0666
Emergency Phone Num:301-881-0666
Preparer's Name:JEROME A HALPERIN
CAGE:14128
=== Contractor Identification ===
Company:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
Box:City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Phone:301-881-0666
CAGE:14128

=============  Composition/Information on Ingredients  =============

Name:THEOPHYLLINE, USP
CAS:58-55-9
RTECS #:XH3850000

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:ORAL LD50(RAT): 244 MG/KG
Routes of Entry: Inhalation:YES  Skin:NO  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:MAY CAUSE IRRITATION TO EYES, SKIN,
    RESPIRATORY TRACT, MUCOUS MEMBRANES. POSSIBLE HYPERSENSITIZATION.
    INGESTION: MAY CAUSE IRRITATION. MATERIAL IS RAPIDLY & COMPLETELY
    ABSORBED FROM GI TRACT. USE OF T HIS MATERIAL DURING PREGNANCY MAY
    CAUSEPOTENTIALLY DANGEROUS SERUM THEOPHYLLINE & CAFFEINE
    CONCENTRATIONS IN NEONATE.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:IRRITATION, BITTER TASTE, HEARTBURN, NAUSEA,
    RESTLESSNESS, VOMITING, CONFUSION, CONVULSIONS, DIARRHEA,
    DIZZINESS, RAPID BREATHING, FAST/POUNDING/IRREGULAR HEARTBEAT,
    FLUSHED FACE, HEADACHE, INCREASED  URINATION, MUSCLE TWITCHING,
    TREMBLING,UNUSUAL TIREDNESS/WEAKNESS, VOMITING BLOOD, SEIZURES,
    ALLERGIC REACTION.
Medical Cond Aggravated by Exposure:HYPERSENSITIVITY TO MATERIAL,
    ACTIVE ALCOHOLISM, LIVER DISEASE, RESPIRATORY INFECTIONS,
    HYPERTHYROIDISM, PROLONGED FEVER, COR PULMONALE, SEVERE HYPOXEMIA,
    HEART PROBLEMS, HYPERTENSION, (SEE SUPP)

=======================  First Aid Measures  =======================

First Aid:INHALATION: REMOVE TO FRESH AIR. EYES/SKIN: FLUSH W/COPIOUS
    QUANTITIES OF WATER. INGESTION: FLUSH MOUTH OUT W/WATER. PERSONS
    DEVELOPING SERIOUS HYPERSENSITIVITY REACTIONS MUST RECEIVE
    IMMEDIATE MEDICA L ATTENTION. GIVE CPR/OXYGEN IF NEEDED.OBTAIN
    MEDICAL ATTENTION IN ALL CASES.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:WATER SPRAY, DRY CHEMICAL, CO2, FOAM AS APPROPRIATE
    FOR SURROUNDING FIRE & MATERIALS.
Fire Fighting Procedures:EVACUATE PERSONNEL TO SAFE AREA. WEAR SCBA &
    PROTECTIVE CLOTHING.
Unusual Fire/Explosion Hazard:THIS MATERIAL IS ASSUMED TO BE
    COMBUSTIBLE. EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR APPROVED RESPIRATOR & CHEMICALLY
    COMPATIBLE GLOVES. VACUUM/SWEEP UP. AVOID DUST. PLACE MATERIAL IN
    APPROPRIATE CONTAINER FOR WASTE DISPOSAL. VENTILATE AREA & WASH
    SITE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE IN TIGHT CONTAINER AS DEFINED IN
    U.S. PHARMACOPIA. USE W/ADEQUATE DUST CONTROL. HANDLE/STORE
    IAW/INSTRUCTIONS TO ENSURE PRODUCT INTEGRITY.
Other Precautions:AVOID CONTACT W/EYES, SKIN/CLOTHING. AVOID BREATHING
    DUST/MIST. DON'T PERMIT EATING, DRINKING/SMOKING NEAR MATERIAL.
    GROUND MECHANICAL EQUIPMENT IN CONTACT W/DRY MATERIAL TO DISSIPATE
    POTENTIAL BUILDU P OF STATIC ELECTRICITY.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR AN APPROVED DUST MASK.
Ventilation:LOCAL EXHAUST/MECHANICAL (GENERAL): RECOMMENDED.
Protective Gloves:RUBBER
Eye Protection:SAFETY GOGGLES
Other Protective Equipment:APPROPRIATE LABORATORY APPAREL
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
    REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
SYMPTOMS: FIBROCYSTIC BREAST DISEASE, GASTRITIS/PEPTIC ULCER, PROSTATIC
    ENLARGEMENT. INDIVIDUALS WORKING W/CHEMICALS SHOULD CONSIDER ALL
    CHEMICALS TO BE POTENTIALLY HAZARDOUS EVEN IF THEIR INDIVIDUAL 
    HAZARDS MAY BE UNCHARACTERIZED/UNKNOWN.

==================  Physical/Chemical Properties  ==================

Melt/Freeze Pt:M.P/F.P Text:518-525.2F
Solubility in Water:SOLUBLE IN HOT WATER
Appearance and Odor:WHITE CRYSTALLINE POWDER W/NO ODOR.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
TANNINS & STRONG OXIDIZING AGENTS.
Stability Condition to Avoid:FIRE.
Hazardous Decomposition Products:WHEN HEATED TO DECOMPOSITION: NITROGEN
    OXIDES.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF IAW/FEDERAL, STATE & LOCAL
    REGULATIONS.

 Disclaimer (provided with this information by the compiling agencies):
 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.

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