===================== Product Identification =====================
MSDS NAME:PROGESTERONE
NIIN:00N082129
MSDS Number: CGCHF
=== Responsible Party ===
Company:SPECTRUM CHEMICAL MFG CORP
Address:14422 SOUTH SAN PEDRO ST
City:GARDENA
State:CA
ZIP:90248
Country:US
Info Phone Num:310-516-8000
Emergency Phone Num:310-516-8000;800-414-9300(CHEMTREC)
CAGE:63415
=== Contractor Identification ===
Company:SPECTRUM LABORATORY PRODUCTS INC
Address:14422 S SAN PEDRO ST
Box:City:GARDENA
State:CA
ZIP:90248-2027
Country:US
Phone:310-516-8000/FAX: 310-516-9843
CAGE:63415
============= Composition/Information on Ingredients =============
Name:PROGESTERONE
CAS:57-83-0
RTECS #:TW0175000
Fraction by Wt: 100%
OSHA PEL:N/K
ACGIH TLV:N/K
Name:SUPDAT: INTERMITTENT, CONTINUOUS ADMIN OF PROGESTIN IN
SUFFICIENT DOSE LEADS TO OVARIAN & ENDOMETRIAL ATROPHY. (ING 3)
RTECS #:9999999ZZ
Name:ING 2: VERY SM DOSES MAY ALTER STRUCTURE OF ENDOMETRIUM.
PRLNGD/RPTD EXPOSURE IN MEN MAY RSLT IN GYNECOMASTIA. (ING 4)
RTECS #:9999999ZZ
Name:ING 3: REPRO EFTS HAVE BEEN REPORTED IN ANIMALS. TOXICITY:
CARCIN STATUS: ANTIC HUMAN CARCIN (NTP); HUMAN INADEQ (ING 5)
RTECS #:9999999ZZ
Name:ING 4: EVID (IARC GROUP 2B FOR PROGESTINS); ANIMAL
SUFFICIENT EVID (IARC). IN ABSENCE OF EPIDEMIOLOGICAL DATA, (ING 6)
RTECS #:9999999ZZ
Name:ING 5: NO EVALUATION OF CARCIN OF PROGESTERONE TO HUMANS
CAN BE MADE. PROGESTERONE WAS TESTED BY SUBCUTANEOUS & (ING 7)
RTECS #:9999999ZZ
Name:ING 6: INTRAMUSC INJECTION IN RATS, MICE, RABBITS & DOGS &
SUBCUTANEOUS IMPLANTATION IN MICE & RATS. IT WAS (ING 8)
RTECS #:9999999ZZ
Name:ING 7: TESTED ALONE IN MICE & DOGS; IN RATS & RABBITS IT
WAS ALWAYS GIVEN IN COMBINATION W/OTHER SEX HORMONES. (ING 9)
RTECS #:9999999ZZ
Name:ING 8:WHEN GIVEN ALONE, IT INCREASED INCIDENCE OF OVARIAN,
UTERINE & MAMMARY TUMORS IN MICE. NEONATAL TREATMENT (ING 10)
RTECS #:9999999ZZ
Name:ING 9: W/PROGESTERONE ENHANCED OCCURRENCE OF PRECANCEROUS &
CANCEROUS LESIONS OF GENITAL TRACT & RSLTD IN INCRD (ING 11)
RTECS #:9999999ZZ
Name:ING 10: MAMMARY TUMORIGENESIS IN FEMALE RATS. TARGET
EFFECTS: POISONING MAY AFFECT THE LIVER.
RTECS #:9999999ZZ
Name:FIRST AID PROC: LOWER LIDS, UNTIL NO EVID OF CHEM REMAINS
(AT LEAST 15-20 MIN). GET MED ATTN IMMED. INGEST: (ING 13)
RTECS #:9999999ZZ
Name:ING 12: TREAT SYMPTOMATICALLY & SUPPORTIVELY. GET MED ATTN
IMMED. IF VOMITING OCCURS, KEEP HEAD LOWER THAN HIPS (ING 14)
RTECS #:9999999ZZ
Name:ING 13: TO PREVENT ASPIRATION. NO SPECIFIC ANTIDOTE. TREAT
SYMPTOMATICALLY & SUPPORTIVELY.
RTECS #:9999999ZZ
Name:RESP PROT: OPERATION, MUST NOT EXCEED WORKING LIMITS OF
RESP & MUST BE NIOSH APPRVD. ANY TYPE 'C' SUPPLIED-AIR (ING 16)
RTECS #:9999999ZZ
Name:ING 15: RESP W/FULL FACEPIECE OPERATED IN PRESS-DEMAND OR
OTHER POSITIVE PRESS MODE OR W/FULL FACEPIECE, HELMET (ING 17)
RTECS #:9999999ZZ
Name:ING 16: OR HOOD OPERATED IN CONTINUOUS-FLOW MODE. ANY SCBA
W/A FULL FACEPIECE OPERATED IN PRESS-DEMAND OR OTHER (ING 18)
RTECS #:9999999ZZ
Name:ING 17: POSITIVE PRESSURE MODE.
RTECS #:9999999ZZ
===================== Hazards Identification =====================
LD50 LC50 Mixture:NONE SPECIFIED BY MANUFACTURER.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:YES IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: INHAL/SKIN CONTACT/INGEST:
AIRBORNE PARTICLES OF SEX HORMONES MAY BE ABSORBED THRU INHAL,
INTACT SKIN AND INGEST. EXCESS PROGESTAGENS IN WOMEN MAY CAUSE
WEIGHT GAIN, ACNE, MASTALGIA, GYNECOMAST IA & RECURRENT MONOLIAL
VAGINITIS. OTHER SYPMS MAY INCL HDCH, NAUS, PHOTOSENS, CHLOASMA,
LOSS OF (EFTS OF OVEREXP)
Explanation of Carcinogenicity:PROGESTERONE: NTP 7TH ANNUAL REPORT ON
CARCINOGENS, 1994:ANTICIPATED TO BE CARCINOGENIC.
Effects of Overexposure:HLTH HAZ: LIBIDO, BREAKTHROUGH BLEEDING,
HYPERTENSION, PORPHYRIA, CHOLESTATIC LIVER DMG & STERILITY. IN MEN
MAY RSLT IN SOME OF GEN SYMPS EXHIBITED BY WOMEN & MAY ALSO INHIBIT
SPERMATOGENESIS. FETAL E XPOS MAY RSLT IN CONGENITAL HEART DEFECTS,
LIMB REDUCTION DEFECTS, VIRILIZATION & GENITAL ABNORMS. EYES:NO
(SUPDAT)
Medical Cond Aggravated by Exposure:NONE SPECIFIED BY MANUFACTURER.
======================= First Aid Measures =======================
First Aid:INHAL: REMOVE TO FRESH AIR IMMED. IF BRTHG STOPS, PERFORM
ARTF RESP. KEEP WARM & AT REST. TREAT SYMP & SUPPORTIVELY. GET MED
ATTN IMMED. SKIN: REMOVE CONTAMD CLTHG & SHOES IMMED. WASH AFFECTED
AREA W/ SOAP OR MILD DETERGENT & LG AMTS OF WATER UNTIL NO EVID OF
CHEM REMAINS (APPROX 15-20 MIN). GET MED ATTN IMMED. EYES: WASH
IMMED W/LARGE AMTS OF WATER OR NORM SALINE OCCASNLY LIFTING UPPER &
(ING 12)
===================== Fire Fighting Measures =====================
Extinguishing Media:DRY CHEMICAL, CARBON DIOXIDE, WATER SPRAY OR
REGULAR FOAM. FOR LARGER FIRES, USE WATER SPRAY, FOG OR REGULAR
FOAM.
Fire Fighting Procedures:USE NIOSH APPRVD SCBA & FULL PROT EQUIP . MOVE
CNTNR FROM FIRE AREA IF W/OUT RISK. DO NOT SCATTER SPILLED MATL
W/HIGH-PRESS WATER STREAMS. DIKE (SUPDAT)
Unusual Fire/Explosion Hazard:NEGLIGIBLE FIRE HAZARD WHEN EXPOSED TO
HEAT OR FLAME.
================== Accidental Release Measures ==================
Spill Release Procedures:WATER SPILL: CA SAFE DRINKING WATER & TOX
ENFORCEMENT ACT OF 1986 (PROPOSITION 65) PROHIBITS CONTAMINATING
ANY KNOWN SOURCE OF DRINKING WATER W/SUBSTANCES KNOWN TO CAUSE
CANCER &/OR REPRO TOXICITY. OC CUP SPILL:NO SPECIAL PRECAUTIONS
INDICATED.
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.
====================== Handling and Storage ======================
Handling and Storage Precautions:NONE SPECIFIED BY MANUFACTURER.
Other Precautions:NONE SPECIFIED BY MANUFACTURER.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:FOLLOWING RESPS ARE RECOMD BASED ON INFO IN
PHYSICAL DATA, TOXICITY & HEALTH EFTS SECTIONS. THEY ARE RANKED IN
ORDER FROM MIN TO MAX RESP PROT. SPECIFIC RESP SELECTED MUST BE
BASED ON CONTAM LEVELS FO UND IN WORK PLACE, SPECIFIC (ING 15)
Ventilation:PROVIDE LOCAL EXHAUST OR PROCESS ENCLOSURE VENTILATION
SYSTEM.
Protective Gloves:IMPERVIOUS GLOVES .
Eye Protection:ANSI APPRVD CHEM WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EYE WASH & DELUGE SHOWER .
APPROP PROT (IMPERVIOUS) CLTHG & EQUIP TO PVNT RPTD/PRLNGD SKIN
CNTCT.
Work Hygienic Practices:NONE SPECIFIED BY MANUFACTURER.
Supplemental Safety and Health
FIRE FIGHT PROCS: FIRE-CONTROL WATER FOR LATER DISP. USE AGENTS
SUITABLE FOR TYPE OF SURROUNDING FIRE. AVOID BRTHG HAZ VAPS, KEEP
UPWIND. EFTS OF OVEREXP: DATA AVAIL. CONTACT W/DUST OR PWDR MAY BE
IRR ITATING. CHRONIC: INHAL/SKIN CONTACT/INGEST: SEX HORMONES MAY
ACCUM & REACH HIGH LEVELS EVEN IF ABSORPTION IS (ING 2)
================== Physical/Chemical Properties ==================
Melt/Freeze Pt:M.P/F.P Text:261F,127C
Spec Gravity:1.17
Solubility in Water:PRACTICALLY INSOL
Appearance and Odor:WHITE CRYSTALLINE POWDER, ODORLESS, LIGHT
SENSITIVE.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZERS: FIRE AND EXPLOSION HAZARD.
Stability Condition to Avoid:NONE SPECIFIED BY MANUFACTURER.
Hazardous Decomposition Products:THERMAL DECOMPOSITION PRODUCTS MAY
INCLUDE TOXIC OXIDES OF CARBON.
==================== Disposal Considerations ====================
Waste Disposal Methods:OBSERVE ALL FEDERAL, STATE AND LOCAL REGULATIONS
WHEN STORING OR DISPOSING OF THIS SUBSTANCE. FOR ASSISTANCE,
CONTACT THE DISTRICT DIRECTOR OF THE ENVIRONMENTAL PROTECTION
AGENCY.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
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