===================== Product Identification =====================
MSDS NAME:QUININE SULFATE, DIHYDRATE
NIIN:00N091090
Status Code:A
MSDS Number: CJFZK
=== Responsible Party ===
Company:FISHER SCIENTIFIC
Address:1 REAGENT LANE
City:FAIR LAWN
State:NJ
ZIP:07410
Country:US
Info Phone Num:201-796-7100
Emergency Phone Num:201-796-7523
Resp. Party Other MSDS Num.:Q3925
Chemtrec Ind/Phone:(800)424-9300
CAGE:1B464
=== Contractor Identification ===
Company:FISHER SCIENTIFIC CO. CHEMICAL MFG DIV
Address:1 REAGENT LANE
Box:City:FAIRLAWN
State:NJ
ZIP:07410-2802
Country:US
Phone:201-796-7100
CAGE:1B464
============= Composition/Information on Ingredients =============
Name:QUININE SULFATE, DIHYDRATE; FOR QUININE SULFATE: 220 MG/KG
ORAL-WOMAN LDLO; 4300 UG/KG ORAL-HUMAN TDLO; 43 MG/KG ORAL-HUMAN
TDLO.
CAS:6119-70-6
= Wt:100.
===================== Hazards Identification =====================
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: INHAL: NO DATA AVAIL. DUST MAY
CAUSE IRRIT. SKIN: NO DATA AVAIL. QUININE IS MARKED LOC IRRITANT &
ANESTH. SENSORY NERVES ARE BRIEFLY STIMULATED THAN PARALYZED. CONCS
ONLY SLIGHTLY HIGHER THAN T HOSE NEC FOR ANESTH ARE LIKELY TO CAUSE
EDEMA, PAIN & REACTIVE FIBROSIS. ANESTH MAY LAST MANY HRS/DAYS.
EYES: NO DATA AVAIL. QUININE IS MARKED LOC IRRITANT & ANESTH.
INGEST: SINGLE LG DOSES MAY CAUE F OLLOWING SYMPS, ANY ONE/GROUP OF
WHICH MAY REPRESENT SYNDROME KNOWN AS "CINCHONISM" OR HYPERSENS
RXN. HEMATOLOGIC SYMPS MAY INCL ACUTE HEMOLYSIS, THROMBOCYTOPENIC
PURPURA, AGRANULOCYTOSIS & HYPOPROTHR OMBINEMIA. CNS EFTS (EFTS OF
OVEREXP)
Effects of Overexposure:EFTS OF OVEREXP: HYPOTENSION & CARD ARREST
POSS. DEATHS REPORTED FROM 1.5-8.0G OF QUININE, ALTHOUGH MUCH
LARGER DOSES TOLERATED. DELIRIUM, COMA/CONVLS MAY OCCUR TERMINALLY.
DEATH MAY OCCUR W/IN FEW HR S/BE DELAYED 1-2 DAYS. PERS RECOVERING
FROM LG AMTS MAY HAVE RESIDUAL OPTIC & AUDITORY DMG. LG DOSES (UP
TO 30G) IN PREGNANT WOMEN HAVE RSLTD IN CONGENITAL MALFORMATIONS
INCL DEAFNESS RELATED TO AUDIT ORY NERVE HYPOPLASIA, LIMB
ANOMALITIES, VISCERAL DEFECTS & VISUAL CHGS. CHRONIC: INHAL:NO DATA
AVAIL AS TO WHETHER RPTD EXPOS MAY RSLT IN "CINCHONIMS" W/SYMPS AS
DESCRIBED IN INGEST. SKIN CNTCT: MAY C AUSE DERM. (SUPDAT)
======================= First Aid Measures =======================
First Aid:INHAL: REMOVE TO FRESH AIR IMMED. IF BRTHG STOPS, PERFORM
ARTF RESP. KEEP WARM & AT REST. TREAT SYMP & SUPPORTIVELY. GET MED
ATTN IMMED. SKIN: REMOVE CONTAM CLTHG & SHOES IMMED. WASH AFFECTED
AREA W/S OAP OR MILD DETERGENT & LG AMTS OF WATER UNTIL NO EVID OF
CHEM REMAINS (APPROX 15-20 MIN). GET MED ATTN IMMED. EYES: WASH
IMMED W/LG AMTS OF WATER OR NORM SALINE, OCCASNLY LIFTING UPPER &
LOWER LIDS U NTIL NO EVID OF CHEM REMAINS (AT LEST 15-20 MIN). GET
MED ATTN IMMED. INGEST: REMOVE BY GASTRIC LAVAGE OR EMESIS.
MAINTAIN BLOOD PRESS & AIRWAY. GIVE OXYG IF RESP IS DEPRESSED. DO
NOT PERFORM GASTRIC (OTHER INFO)
===================== Fire Fighting Measures =====================
Extinguishing Media:DRY CHEM, CARBON DIOXIDE, HALON, WATER SPRAY OR
STANDARD FOAM. FOR LARGER FIRES, USE WATER SPRAY, FOG OR STANDARD
FOAM. (1987 EMERGENCY RESPONSE GUIDEBOOK, DOT P 5800.4).
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT . NO ACUT HAZARD. MOVE CONTAINER FROM FIRE AREA IF
POSSIBLE. AVOID BREATHING VAPORS OR DUSTS; KEEP UPWIND.
Unusual Fire/Explosion Hazard:NEGLIGIBLE FIRE HAZARD WHEN EXPOSED TO
HEAT OR FLAME. NFPA RATINGS (SCALE 0-4): HEALTH=3; FIRE=0;
REACTIVITY=0.
================== Accidental Release Measures ==================
Spill Release Procedures:SWEEP UP AND PLACE IN SUITABLE (FIBERBOARD)
CONTAINERS FOR RECLAMATION OR LATER DISPOSAL.
====================== Handling and Storage ======================
Handling and Storage Precautions:MAY BURN BUT DOES NOT IGNITE READILY.
AVOID CONTACT WITH STRONG OXIDIZERS, EXCESSIVE HEAT, SPARKS OR OPEN
FLAMES.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:FOLLOWING RESPS RECOM BASED ON INFO FOUND IN
PHYSICAL DATA, TOX & HLTH EFTS SECTIONS. RANKED IN ORDER FROM MIN
TO MAX RESP PROT. RESP SELECTED MUST BE BASED ON CONTAM LEVELS
FOUND IN WORK PLACE, MUST NOT EXCEED WORKING LIMS OF RESP & BE
NIOSH APPRVD. CHEM CARTRIDGE RESP W/FULL FACEPIECE & ORG VAP
CARTRIDGE(S) IN COMBINATION W/DUST & (OTHER INFO)
Ventilation:PROVIDE LOCAL EXHAUST OR PROCESS ENCLOSURE VENTILATION
SYSTEM.
Protective Gloves:IMPERVIOUS GLOVES .
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:EMERGENCY EYE WASH & DELUGE SHOWER MEETING
ANSI DESIGN CRITERIA . APPROP PROT (IMPERVIOUS) CLTHG & EQUIP TO
PREVENT RPTD OR PRLNGD SKIN CONTACT W/THIS SUBSTANCE.
Supplemental Safety and Health
EFTS OF OVEREXP: EYES:NO DATA AVAIL. INGEST:RPTD EXPOS MAY CAUSE
"CINCHONISM" CHARACT BY TINNUITUS, HDCH, VERTIGO, NAUS & DISTURBED
VISION W/BILATERAL DILATED PUPILS, PALLOR OF OPTIC DISKS, NARROWING
OF RETINAL VESSELS, PAPILLEDEMA & LATE CONSTRICTION OF VISUAL
FIELDS. IF CONTINUED, SYMPS MAY ALSO INVOLVE (OTHER INFO)
================== Physical/Chemical Properties ==================
Melt/Freeze Pt:=205.C, 401.F
Spec Gravity:NOT AVAIL
pH:6.2 @ SATD SOLN
Solubility in Water:0.12-0.2%
Appearance and Odor:ODORLESS, SILKY, WHITE POWDER OR FINE CRYSTALS
WHICH BECOME (TRANSPORT INFO)
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
QUININE SULFATE: NONE KNOWN.
Stability Condition to Avoid:STABLE UNDER NORMAL TEMPERATURES AND
PRESSURES.
Hazardous Decomposition Products:THERMAL DECOMPOSITION MAY RELEASE
TOXIC OXIDES OF NITROGEN AND SULFUR.
=================== Toxicological Information ===================
Toxicological Information:QUININE SULFATE, DIHYDRATE: CARCIN STATUS:
NONE. POISONING MAY EFT SKIN, BLOOD & GI, RESP, CVS & NERVOUS
SYSTEMS, PARTICULARLY W/EFTS ON VISION & HEARING. PERS
W/GLUCOSE-6-PD DEFICIENCY MAY BE AT INCR EASED RISK FROM EXPOS DUE
TO SUSCEPTIBILITY TO HEMOLYSIS. CONCURRENT USE OF THIS SUBSTANCE
W/OTHER VARIOUS DRUGS MAY CAUSE ADVERSE EFTS AS NOTED. QUININE TOX
MAY BE ENHANCED BY FOODS/DRUGS THAT ALKALI NIZE URINE THUS
INCREASING RENAL ABSORPTION. ADDITIVE EFT MAY OCCUR W/CENTRALLY &
PERIPHERALLY ACTING ANTICHOLINERGICS. BONE MARROW DEPRESS ADDITIVE
EFT MAY OCCUR W/MYELOSUPPRESSANTS, INCLUDING RADIA THERAPY.
ADDITIVE (TRANSPORT)
===================== Ecological Information =====================
Ecological:OTHER INFO: PARTICULATE FILTER. POWERED AIR-PURIFYING RESP
W/TIGHT-FITTING FACEPIECE & ORG VAP CARTRIDGE(S) IN COMBINATION
W/HIGH-EFFICIENCY PARTICULATE FILTER. TYPE 'C' SUPPLIED-AIR RESP
W/FULL FACEP IECE OPERATED IN PRESS-DEMAND OR OTHER POS PRESS MODE
OR W/FULL FACEPIECE, HELMET/HOOD OPERATED IN CONTINUOUS-FLOW MODE.
SCBA W/FULL FACEPIECE OPERATED IN PRESS-DEMAND OR OTHER POS PRESS
MODE. FIREFIG HTING & OTHER IMMED DANGEROUS TO LIFE/HEALTH CNDTNS:
SCBA W/FULL FACEPIECE OPERATED IN PRESS-DEMAND OR OTHER POS PRESS
MODE. SUPPLIED-AIR RESP W/FULL FACEPIECE & OPERATED IN PRESS-DEMAND
OR OTHER POS PRESS MODE IN COMBINATION (TRANSPORT)
==================== Disposal Considerations ====================
Waste Disposal Methods:DISPOSAL MUST BE IN ACCORDANCE WITH FEDERAL,
STATE AND LOCAL REGULATIONS .
=================== MSDS Transport Information ===================
Transport Information:ECOLOGICAL INFO: W/AUXILIARY SCBA OPERATED IN
PRESS-DEMAND OR OTHER POS PRESS MODE. APPEAR/ODOR: BROWNISH ON
EXPOSURE TO LIGHT; VERY PERSISTENT BITTER TASTE. TOXICOLOGICAL
INFO: HYPOTENSION MAY OCCUR W/ANTIHYPERTENSIVES. INCREASED SERUM
LEVELS OF DIGOXIN MAY OCCUR. ADDITIVE HEPATOTOXICITY MAY OCCUR
W/MERCAPTOPURINE. EFTS OF QUININE MAY BE DECREASED BY BARBITURATES,
PRIMIDONE, PHENYTOIN & OTHER HYD ANTOINS & RIFAMPIN WHICH WILL ALSO
RSLT IN INCREASED METABOLISM. ADDITIVE NEUROMUSC BLOCKADE, ESP RESP
DEPRESS THAT CAN PROGRESS TO APNEA MAY OCUR W/CURARIFORM DRUGS.
ADDITIVE EKG EFTS W/POSS INCREASE D CARDIOTOX EFTS SUCH AS (SARA
III)
===================== Regulatory Information =====================
SARA Title III Information:TRANSPORT: ARRHYTHIAS & CARDIAC DEPRESS MAY
OCCUR W/TRICYCLIC ANTIDEPRESSANTS.
Federal Regulatory Information:CERCLA RATINGS (SCALE 0-3): HEALTH=3;
FIRE=0; REACTIVITY=0. PERSISTENCE=2.
State Regulatory Information:
======================= Other Information =======================
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
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