===================== Product Identification =====================
MSDS NAME:1-METHYL-2-PYRROLIDINONE, ANHYDROUS 99.5%, 328634
NIIN:00N093024
Status Code:A
MSDS Number: CJWYY
=== Responsible Party ===
Company:ALDRICH CHEMICAL CO INC
Address:1001 WEST ST PAUL
City:MILWAUKEE
State:WI
ZIP:53233
Country:US
Info Phone Num:414-273-3850
Emergency Phone Num:414-273-3850
CAGE:60928
=== Contractor Identification ===
Company:ALDRICH CHEMICAL CO INC
Address:1001 WEST ST PAUL AVE
Box:355
City:MILWAUKEE
State:WI
ZIP:53233
Country:US
Phone:414-273-3850
CAGE:60928
============= Composition/Information on Ingredients =============
Name:1-METHYL-2-PYRROLIDINONE
CAS:872-50-4
RTECS #:UY5790000
= Wt:99.5
===================== Hazards Identification =====================
LD50 LC50 Mixture:LD50: (ORAL,RAT) 3914 MG/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: HARMFUL IF SWALLOWED, INHALED,
OR ABSORBED THROUGH SKIN. VAPOR OR MIST IS IRRITATING TO THE EYES,
MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. CAUSES SKIN
IRRITATION. PROLONGED EXPOSURE CAN CA USE: STOMACH PAINS, VOMITING,
DIARRHEA. CHRONIC: OVEREXPOSURE MAY CAUSE REPRODUCTIVE DISORDER(S)
BASED ON TESTS WITH LABORATORY ANIMALS. TARGET ORGAN(S): BONE
MARROW, THYMUS, SPLEEN, LYMPHATIC SYSTEM. ADDNL INFO: RATS EXPOSED
TO 1-METHYL-2-PYRROLIDINONE AT CONCENTRATION OF 1 MG/L AS AN
AEROSOL FOR 10 DAYS SHOWED DEPLETION OF HEMATOPOIETIC CELLS IN THE
BONE MARROW AND (EFTS OF OVEREXP)
Effects of Overexposure:HLTH HAZS: ATROPHY OF THE LYMPHOID TISSUES OF
THE THYMUS, SPLEEN AND LYMPH NODES.
======================= First Aid Measures =======================
First Aid:IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH
COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING
CONTAMINATED CLOTHING AND SHOES. ASSURE ADEQUATE FLUSHING OF THE
EYES BY SEPARAT ING EYELIDS WITH FINGERS. IF INHALED, REMOVE TO
FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL RESPIRATION. IF
BREATHING IS DIFFICULT, GIVE OXYGEN. IF SWALLOWED, WASH OUT MOUTH
WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL PHYSICIAN. REMOVE
AND WASH CONTAMINATED CLOTHING PROMPTLY. DISCARD CONTAMINATED
SHOES.
===================== Fire Fighting Measures =====================
Flash Point:=86.1C, 187.F
Autoignition Temp:=270.C, 518.F
Lower Limits:1.3%
Upper Limits:9.5%
Extinguishing Media:WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER OR
APPROPRIATE FOAM.
Fire Fighting Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
APPARATUS AND PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN AND
EYES. COMBUSTIBLE LIQUID.
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
================== Accidental Release Measures ==================
Spill Release Procedures:EVACUATE AREA. WEAR NIOSH APPRVD
SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY RUBBER
GLOVES. ABSORB ON SAND OR VERMICULITE AND PLACE IN CLOSED
CONTAINERS FOR DISPOSAL. VENTILATE AREA AND WASH SPILL SITE AFTER
MATERIAL PICKUP IS COMPLETE.
====================== Handling and Storage ======================
Handling and Storage Precautions:DO NOT BREATHE VAPOR. AVOID CONTACT
W/EYES, SKIN & CLTHG. SKIN ABSORP MAY OCCUR. HARMFUL LIQUID.
IRRITANT. POSSIBLE TERATOGEN. KEEP TIGHTLY CLOSED. KEEP AWAY FROM
HEAT AND OPEN FLAME. STORE IN A COOL DRY PLACE.
Other Precautions:COMBUSTIBLE. IN CASE OF CONT W/EYES, RINSE IMMED
W/PLENTY OF WATER & SEEK MED ADVICE. IN CASE OF FIRE AND/OR EXPLO
DO NOT BREATHE FUMES. WEAR SUITABLE PROT CLTHG, GLOVES AND EYE/FACE
PROTECTION. HYGRO SCOPIC. HANDLE AND STORE UNDER NITROGEN.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:NIOSH APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:WEAR HEAVY RUBBER GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:EYE WASH & DELUGE SHOWER MEETING ANSI DESIGN
CRITERIA .
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
VP: 0.29MM 20C - 0.99MM 40 C. TOX INFO: (POST-IMPLANTATION MORTALITY).
SPECIFIC DEVELOPMENTAL ABNORMAL: (CNS), (MUSCULOSKELETAL SYS). EFTS
ON NEWBORN: (GROWTH STATISTICS), (DELAYED EFTS). ONLY SELECTE D
REGISTRY OF TOXIC EFTS OF CHEM SUBSTANCES (RTECS) DATA IS PRESENTED
HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE INFO.
================== Physical/Chemical Properties ==================
Boiling Pt:=81.C, 177.8F
B.P. Text:81-82C/10MM
Melt/Freeze Pt:=-24.C, -11.2F
Vapor Pres:SUPDAT
Vapor Density:3.4
Spec Gravity:1.028
Appearance and Odor:COLORLESS LIQUID.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
STRONG ACIDS, STRONG OXIDIZING AGENTS.
Stability Condition to Avoid:PROTECT FROM MOISTURE.
Hazardous Decomposition Products:THERMAL DECOMPOSITION MAY PRODUCE
CARBON MONOXIDE, CARBON DIOXIDE, AND NITROGEN OXIDES.
=================== Toxicological Information ===================
Toxicological Information:RTECS#: UY5790000. 2-PYRROLIDINONE, 1-METHYL-
IRRITATION DATA: EYE-RBT 100 MG MOD. FCTOD7 26,475,1988. TOX DATA:
ORL-RAT LD50:3914 MG/KG. ARZNAD 26,1581,1976. IPR-RAT LD50:2472
MG/KG. ARZNAD 26,1581,1 976. SCU-RAT LD50:>2 GM/KG. USXXAM
#4882359. IVN-RAT LD50:80500 UG/KG. IYKEDH 18,922,1987. UNR-RAT
LD50: 7 GM/KG. 34ZIAG -,408,1969. ORL-MUS LD50:5130 MG/KG. EPASR*
8EHQ-1087-0695. IPR-MUS LD50:3050 M G/KG. EPASR* 8EHQ-1087-0695.
IVN-MUS LD50:54500 UG/KG. IYKEDH 18,922,1987. IVN-DOG LD50:63300
UG/KG. IYKEDH 18,922,1987. SKN-RBT LD50:8 GM/KG. NPIRI* 1,84,1974.
TARGET ORGAN DATA: EFTS OF FERTILITY (S UPDAT)
===================== Ecological Information =====================
Ecological:DATA NOT AVAILABLE.
==================== Disposal Considerations ====================
Waste Disposal Methods:THIS COMBUSTIBLE MATERIAL MAY BE BURNED IN A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
=================== MSDS Transport Information ===================
Transport Information:CONTACT ALDRICH CHEMICAL COMPANY FOR
TRANSPORTATION INFORMATION.
===================== Regulatory Information =====================
SARA Title III Information:U.S. INFORMATION. THIS PRODUCT IS SUBJECT TO
SARA SECTION 313 REPORTING REQUIREMENTS.
Federal Regulatory Information:EUROPEAN INFO. EC INDEX NO:
606-021-00-7. HARMFUL. R 36/38. IRRITATING TO EYES & SKIN. S 41.
INCASE OF FIRE AND/OR EXPLO DO NOT BREATHE FUMES. REVIEWS, STDS, &
REGS. OEL=MAK. OEL-DENMARK:TWA 100 PPM ( 400 MG/M3) JAN 1993.
OEL-GERMANY:TWA 100 PPM (400 MG/M3) JAN 1993. OEL-THE NETHERLANDS:
TWA 100 PPM (400 MG/M3) JAN 1993. OEL-RUSSIA:STEL 100 MG/M3 JAN
1993. OEL-SWITZERLAND:TWA 200 PPM (400 MG/M3) JA N 1993. OEL-UNITED
KINGDOM:TWA 100 PPM (400 MG/M3) JAN 1993. NOHS 1974: HZD M1569; NIS
30; TNF 2458; NOS 43; TNE 25255. NOES 1983: HZD M1569; NIS 63; TNF
3902; NOS 73; TNE 85169; TFE 23478. (OTHER INFO)
======================= Other Information =======================
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
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