===================== Product Identification =====================
MSDS NAME:1,1,2-TRICHLORO-1,2,2-TRIFLUOROETHANE, T178
NIIN:00N093436
Status Code:A
MSDS Number: CJYFV
=== Responsible Party ===
Company:FISHER SCIENTIFIC
Address:1 REAGENT LANE
City:FAIRLAWN
State:NJ
ZIP:07410
Country:US
Info Phone Num:201-796-7100
Emergency Phone Num:800-424-9300
Chemtrec Ind/Phone:(800)424-9300
CAGE:1B464
=== Contractor Identification ===
Company:FISHER SCIENTIFIC CO. CHEMICAL MFG DIV
Address:1 REAGENT LANE
Box:City:FAIRLAWN
State:NJ
ZIP:07410-2802
Country:US
Phone:201-796-7100
CAGE:1B464
Company:SCIENTIFIC SUPPLY AND EQUIPMENT INC
Address:926 POPLAR PL
Box:22607
City:SEATTLE
State:WA
ZIP:98144
Country:US
Phone:206-324-8550
CAGE:6M140
============= Composition/Information on Ingredients =============
Name:1,1,2-TRICHLORO-1,2,2-TRIFLUOROETHANE
CAS:76-13-1
RTECS #:KJ4000000
= Wt:100.
OSHA PEL:7600 MG/M3;1000 PPM
ACGIH TLV:7670 MG/M3;1000 PPM
ACGIH STEL:9590 MG/M3;1250 PPM
Ozone Depleting Chemical:1
===================== Hazards Identification =====================
LD50 LC50 Mixture:LD50: (ORAL,RAT) 43 GM/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:1,1,2-TRICHLORO-1,2,2-TRIFLUOROETHANE
(FREON TF): NARCOTICS/SIMPLE ASPHYXIANT. 4500 PPM IMMED DANGEROUS
TO LIFE/HLTH. ACUTE: MAY CAUSE MILD IRRIT OF MUC MEMB OF UPPER RESP
TRACT. MAY BE ANESTH & CAUSE CNS DEPRESS W/DROW & ARRHYS. HUMANS
EXPOSED TO 2500-4500 PPM FOR 30-100 MINS SHOWED SIGNIFICANT
IMPAIRMENT OF MANUAL DEXTERITY & VIGILANCE, LOSS OF CONC,
SOMNOLENCE & HEAVINESS IN HEAD, WHICH DISAPPE ARED 15 MINS AFTER
EXPOS ENDED. SIMPLE ASPHYX MAY OCCUR @ HIGH CONCS. OVEREXP COULD
RSLT IN EPINEPHINE SENSITIZ OF HEART & SUBSEQUENTLY MAY CAUSE DEATH
FROM VENTRICULAR FIBRILLATION UNDER (EFTS OF OVE REXP)
Effects of Overexposure:HLTH HAZS: PHYSICAL/EMOTIONAL STRESS. DOGS
EXPOSED TO 11,000-13,000 PPM FOR 6 HRS EXPERIENCED VOMIT, LETHARGY,
NERVOUSNESS, & TREMORS. ALL SYMPS WERE REVERSIBLE W/IN 15 MINS. IN
EXPERIMENTAL ANIMALS, VARIABLE DEGREES OF CARDIODYNAMIC EFTS THAT
INCL TACHYCARDIA, MYOCARDIAL DEPRESS, & HYPOTENSION HAVE BEEN
REPORTED. PULM EDEMA & SEV VENTRICULAR DYSRHYTHMIA MAY RSLT FROM
INHAL OF FREONS. CHLOROFLUORO CARBON (CFC) MATLS HAVE PRDCED
SENSITIZ OF MYOCARDIUM TO EPINEPHRINE IN LAB ANIMALS & COULD HAVE
SIMILAR EFT IN HUMANS. ADRENOMIMETICS (I.E., EPINEPHRINE) (SUPDAT)
Medical Cond Aggravated by Exposure:PERSONS WITH PRE-EXISTING SKIN
DISORDERS, IMPAIRED CARDIOVASCULAR FUNCTION, PARTICULARLY CARDIAC
ARRYTHMIAS OR IMPAIRED RESPIRATORY FUNCTION.
======================= First Aid Measures =======================
First Aid:INHAL: REMOVE TO FRESH AIR IMMED. PERFORM ARTF RESP IF NEC.
KEEP PERSON WARM & AT REST. TREAT SYMPTOMATICALLY & SUPPORTIVELY.
GET MED ATTN IMMED. SKIN: REMOVE CONTAMD CLTHG & SHOES IMMED. WASH
W/SOAP OR MILD DETERGENT & LG AMTS OF WATER UNTIL NO EVID OF CHEM
REMAINS (@ LST 15-20 MINS). GET MED ATTN IMMED. EYES: WASH IMMED
W/LG AMTS OF WATER/NORMAL SALINE, OCCASNLY LIFTING UPPER & LOWER
LIDS, UNTIL NO EVID OF CHEM REMAINS (@ LST 15 MINS). GET MED ATTN
IMMED. INGEST: IF VOMIT OCCURS, KEEP HEAD LOWER THAN HIPS TO HELP
PVNT ASPIR. TREAT SYMPTOMATICALLY (TRANSPORT INFO)
===================== Fire Fighting Measures =====================
Autoignition Temp:=680.C, 1256.F
Extinguishing Media:DRY CHEM, CO&2, WATER SPRAY/REGULAR FOAM. FOR LGR
FIRES, USE WATER SPRAY, FOG/ REGULAR FOAM. (1993 EMERG RESPONSE
GUIDEBOOK, RSPA P 5800.6). USE AGENTS SUITABLE FOR (TRANSPORT INFO)
Fire Fighting Procedures:WEAR NIOSH APPRVD PRESSURE DEMAND SCBA & FULL
PROTECTIVE EQUIPMENT . MOVE CONTAINER FROM FIRE AREA IF YOU CAN DO
IT W/OUT RISK. DO NOT SCATTER SPILLED MATL W/HIGH-PRESSURE WATER
STREAMS. DIKE FI RE-CONTROL WATER FOR LATER DISP (1993 EMER
RESPONSE GUIDEBOOK, RSPA P 5800.6, GUIDE PG 31).
Unusual Fire/Explosion Hazard:NEGLIGIBLE FIRE HAZARD WHEN EXPOSED TO
HEAT OR FLAMES. THERMAL DECOMPOSITION PRODUCTS MAY INCLUDE
CHLORIDES, FLUORIDES & PHOSGENE .
================== Accidental Release Measures ==================
Spill Release Procedures:OCCUPATIONAL SPILL: STOP LEAK IF YOU CAN DO IT
W/OUT RISK. FOR SMALL SPILLS, TAKE UP W/SAND OR OTHER ABSORBENT
MATERIAL AND PLACE INTO CLEAN, DRY CONTAINERS FOR LATER DISPOSAL.
KEEP UNNECESSARY PEOPLE AWAY. ISOLATE HAZARD AREA AND DENY ENTRY.
====================== Handling and Storage ======================
Handling and Storage Precautions:STORE AWAY FROM INCOMPATIBLE
SUBSTANCES. KEEP IN A TIGHTLY CLOSED CONTAINER. STORE IN A COOL,
DRY, VENTILATED AREA. OBSERVE ALL FEDERAL, STATE AND LOCAL
REGULATIONS WHEN STORING THIS SUBSTANCE.
Other Precautions:NO SMOKING IN AREA OF USE. DO NOT USE IN GENERAL
VICINITY OF ARC WELDING, OPEN FLAMES OR HOT SURFACES. HEAT AND/OR
UV RADIATION MAY CAUSE FORMATION OF CHLORIDES, FLUORIDES AND
PHOSGENE .
============= Exposure Controls/Personal Protection =============
Respiratory Protection:FOLLOWING RESPS & MAX USE CONCS ARE REC BY U.S.
DEPT OF HLTH & HUMAN SERVICES, NIOSH POCKET GUIDE TO CHEM HAZS;
NIOSH CRITERIA DOCUMENTS/BY U.S. DEPT OF LABOR, 29 CFR 1910 SUBPART
2. SPECIFIC RESP SEL ECTED MUST BE BASED ON CONTAM LEVS FOUND IN
WORKPLACE, MUST NOT EXCEED WORKING LIMS OF RESP & BE APPRVD BY
NIOSH. 4500 PPM - ANY NIOSH APPRVD(TRANSPORT INFO)
Ventilation:PROVIDE GENERAL DILUTION VENTILATION TO MEET PUBLISHED
EXPOSURE LIMITS.
Protective Gloves:IMPERVIOUS GLOVES .
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:EYE WASH & DELUGE SHOWER MEETING ANSI DESIGN
CRITERIA . EMPLOYEE MUST WEAR APPROP PROT (IMPERVIOUS) CLTHG &
EQUIP TO PVNT RPTD/PRLNGD SKIN CONT W/THIS SUBSTANCE.
Supplemental Safety and Health
EFTS OF OVEREXP: MAY BE CONTRA-INDICATED EXCEPT FOR LIFE-SUSTAINING
USES IN HUMANS ACUTELY/CHRONICALLY EXPOSED TO CFC'S . CHRONIC:
PRLNGD HUMAN EXPOS FOR 2 WKS @ CONCS OF APPROX 500 & 1000 PPM C
AUSED MILD THROAT IRRIT ON 1ST DAY, BUT NO DECREMENT IN PERFORMANCE
OF COMPLEX MENTAL TASKS. (OTHER INFO)
================== Physical/Chemical Properties ==================
Boiling Pt:=45.8C, 114.4F
Melt/Freeze Pt:=13.2C, 55.8F
Vapor Pres:284 MMHG @ 20C
Vapor Density:6(APPROX)
Spec Gravity:1.6 @ 77F
Evaporation Rate & Reference:0.45 (ACETONE =1)
Solubility in Water:0.028%
Appearance and Odor:COLORLESS LIQUID WITH AN ODOR LIKE AMMONIA AT HIGH
CONCENTRATIONS.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
ALKALI METALS: VIOLENT RXN POSS. ALUMINUM (POWDERED): FORMS
SHOCK-SENSITIVE MIX. BARIUM (POWDERED): FORMS EXPLO MIX. BERYLLIUM
& CALCIUM: VIOLENT RXN POSS. LITHIUM (POWDERED): FORMS (STATE
REGULATORY INFO)
Stability Condition to Avoid:STABLE UNDER NORMAL TEMPS & PRESSURES. MAY
BURN BUT DOES NOT IGNITE READILY. AVOID CONTACT WITH STRONG
OXIDIZERS, EXCESSIVE HEAT, SPARKS, OR OPEN FLAME.
Hazardous Decomposition Products:THERMAL DECOMPOSITION PRODUCTS MAY
INCLUDE TOXIC AND CORROSIVE FUMES OF CHLORIDES AND FLUORIDES, AND
TOXIC OXIDES OF CARBON. PHOSGENE .
Conditions to Avoid Polymerization:HAZARDOUS POLYMERIZATION HAS NOT
BEEN REPORTED TO OCCUR UNDER NORMAL TEMPERATURES AND PRESSURES.
=================== Toxicological Information ===================
Toxicological Information:IRRIT DATA: 500 MG OPEN SKIN-RABBIT MILD; 500
MG/24 HRS SKIN-RABBIT MILD. TOXICITY DATA: 87000 PPM/6 HRS
INHAL-RAT LCLO: 25 PPH/90 SECONDS INHAL-MOUSE LCLO; 20 PPH/6 HRS/2
YRS-INTERMITTENT INHAL-RAT T CLO: 43 GM/KG ORAL-RAT LD50:
CARCINOGEN STATUS: NONE. ACUTE TOX LEVEL: RELATIVELY NON-TOXIC BY
INHAL & INGEST. TARGET EFTS: CNS DEPRESSANT; SIMPLE ASPHY.
POISONING MAY ALSO AFFECT LIVER & KIDNEYS. ADD ITIONAL DATA:
STIMULANTS SUCH AS EPINEPHRINE MAY INDUCE VENTRICULAR FIBRILLATION.
===================== Ecological Information =====================
Ecological:N/P -OTHER INFO: 5 GM/KG W/RABBIT SKIN FOR 5 SUCCESSIVE DAYS
RSLTD IN LOC NECROSIS & SLOUGHING PLUS CONSPICUOUS ENLARGEMENT OF
LIVER CELLS. EYE CONT: ACUTE: MAY CAUSE IRRIT. APPLIC OF 0.1 ML TO
RABBIT EYES IS REPORTED TO HAVE PRDCED ONLY MILD CONJ & MINIMAL
CORNEAL DULLNESS @ 24 HRS. ALL EYES RETURNED TO NORMAL W/IN 48 HRS.
CHRONIC: NO DATA AVAIL. INGEST:NARCOTIC. ACUTE: ONE HUMAN
ACCIDENTALLY REC EIVED 1 LITER OF
1,1,2-TRICHLORO-1,2,2-TRIFLUOROETHANE IN STOM WHILE UNDER ANESTH.
THIS PRDCED IMMED BUT TRANSIENT CYANOSIS. INDIVIDUAL SURVIVED &
RPTD ONLY SEV RECTAL IRRIT & DIARR FOR 3 DAYS THEREAF TER.
(TRANSPORT INFO)
==================== Disposal Considerations ====================
Waste Disposal Methods:OBSERVE ALL FEDERAL, STATE AND LOCAL REGULATIONS
WHEN STORING OR DISPOSING OF THIS SUBSTANCE.
=================== MSDS Transport Information ===================
Transport Information:N/P -ECOLOGICAL INFO: IF SUFFICIENT AMTS ARE
INGESTED, SYSTEMIC TOX MAY OCCUR AS DETAILED IN ACUTE INHAL. INGEST
OF HYDROCARBONS IS ASSOC W/PNEUM, CNS DEPRESS & ARRHYS. CHRONIC: NO
CHANGES WERE PRDCED IN OFFSPRING OF PREGNANT RABBITS EXPOSED
ORALLY. FIRST AID PROC: & SUPPORTIVELY. GET MED ATTN IF NEEDED.
ANTIDOTE: NO SPECIFIC ANTIDOTE. TREAT SYMPTOMATICALLY &
SUPPORTIVELY. EXTING MEDIA: TYPE OF SU RROUNDING FIRE. AVOID BRTHG
HAZ VAPS, KEEP UPWIND. RESP PROT: SUPPLIED-AIR RESP. ANY NIOSH
APPRVD SCBA. ESCAPE-ANY NIOSH APPRVD AIR-PURIFYING FULL FACEPIECE
RESP (GAS MASK) (FED REGULATORY INFO)
===================== Regulatory Information =====================
SARA Title III Information:SUBJECT TO SARA SECTION 313 ANNUAL TOXIC
CHEMICAL RELEASE REPORTING. COMPONENTS AND CONTAMINANTS. EXPOSURE
LIMITS: 1000 PPM (7670 MG/M3) OSHA TWA; 1250 PPM (9590 MG/M3) OSHA
STEL. 1000 PPM (7670 MG/M3 ) ACGIH TWA; 1250 PPM (9590 MG/M3) ACGIH
STEL. 1000 PPM (7670 MG/M3) NIOSH REC TWA; 1250 PPM (9590 MG/M3)
NIOSH REC STEL. 500 PPM (3832 MG/M3) DFG MAK TWA; 1000 PPM (7670
MG/M3) DFG MAK 60 MIN PEAK, M OMENTARY VALUE, 3 TIMES/SHIFT.
MEASUREMENT METH: CHARCOAL TUBE; CARBON DISULFIDE; GAS
CHROMATOGRAPHY WITH FLAME IONIZATION DETECTION; (NIOSH. VOL. III #
1020).
Federal Regulatory Information:OSHA REVOKED THE FINAL RULE LIMIT OF
JANUARY 19, 1989 IN RESPONSE TO THE 11TH CIRCUIT COURT OF APPEALS
DECISION (AFL CIO V. OSHA). EFFECTIVE (CONT NEHC FOR COMPLETE
INFO). -- TRANSPORT INFO: WITH NIOSH APPRVD CHIN
STYLE/FRONT OR BACK-MOUNTED ORG VAP CANISTER. ANY APPROP
ESCAPE-TYPE NIOSH APPRVD SCBA. FOR FIREFIGHTING & OTHER IMMED
DANGEROUS TO LIFE/HLTH CNDTNS: ANY NIOSH APPRVD SCB A THAT HAS FULL
FACEPIECE & IS OPERATED IN PRESS-DEMAND/OTHER POS-PRESS MODE. ANY
NIOSH APPRVD SUPPL IED-AIR RESP THAT HAS A FULL FACEPIECE & IS
OPERATED IN PRESS-DEMAND OR OTHER POS-PRESS MODE (STATE REGULATORY
INFO)
State Regulatory Information:N/P -FED REGULATORY INFO: IN COMBINATION
WITH AN NIOSH APPRVD AUXILIARY SCBA OPERATED IN PRESS-DEMAND OR
OTHER POSITIVE-PRESSURE MODE. MATLS TO AVOID: EXPLOSIVE MIX.
MAGNESIUM: VIOLENT RXN POSS. MAGNE SIUM ALLOY: DECOMP POSS.
PLASTICS, RUBBER, COATINGS: MAY BE ATTACKED. POTASSIUM: FORMS
IGNITABLE CMPD. SAMARIUM: EXPLODES ON FRICTION. SODIUM: FORMS
IGNITABLE COMPOUND. SODIUM-POTASSIUM ALLOY: VIOLENT EXPLOSION.
TITANIUM (POWDERED): FORMS SHOCK-SENSITIVE MIXTURE. ZINC: VIOLENT
REACTION POSSIBLE.
======================= Other Information =======================
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
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