===================== Product Identification =====================
MSDS NAME:9041-9047, BUPIVACAINE AND EPINEPHRINE INJECTION,USP
NIIN:00-927-4840
Status Code:A
Kit Part:Y
MSDS Number: CKTNF
=== Responsible Party ===
Company:ABBOTT LABORATORIES, HOSPITAL PRODUCTS DIV
Address:COR OF 137TH AND 43RD ST
City:NORTH CHICAGO(ABBOTT PARK)
State:IL
ZIP:60064
Country:US
Info Phone Num:800-255-5162, 847-937-7970
Emergency Phone Num:800-424-9300
Chemtrec Ind/Phone:(800)424-9300
CAGE:0BJ95
=== Contractor Identification ===
Company:ABBOTT LABORATORIES HOSPITAL PRODUCTS DIV
Address:COR OF 137TH AND 43RD ST
Box:City:ABBOTT PARK
State:IL
ZIP:60064
Country:US
Phone:800-255-5162/847-937-7970
CAGE:0BJ95
============= Composition/Information on Ingredients =============
Name:EPINEPHRINE
CAS:51-43-4
RTECS #:DO2625000
EPA Rpt Qty:1000 LBS
DOT Rpt Qty:1000 LBS
Name:BUPIVACAINE HYDROCHLORIDE
CAS:14252-80-3
RTECS #:TK6125000
===================== Hazards Identification =====================
Routes of Entry: Inhalation:NO Skin:NO Ingestion:NO
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:TARGET ORGANS: SKIN, NERVOUS SYSTEM,
CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR SYSTEM AND RESPIRATORY
SYSTEM. INGESTION RATING: POSSIBLY HIGHLY TOXIC. SKIN ABSORPTION
RATING: POSSIBLY HIGHLY TOXIC. INHAL ATION RATING: N/D.
CORROSIVENESS RATING: N/D. SKIN CONTACT RATING: N/D. SKIN
SENSITIZATION RATING: N/D. EYE CONTACT RATING: N/D
Explanation of Carcinogenicity:NONE.
Effects of Overexposure:N/D. IN CLILNICAL USE, EFFECTS INCLUDE
NUMBNESS, EXCITATION/DEPRESSION, RESTLESSNESS, ANXIETY, DIZZINESS,
TINNITUS, BLURRED VISION, TREMORS, CONVULSIONS, HYPOTENSION,
BRADYCARDIA, VENTRICULAR ARRYTHMI AS, HEART BLOCK AND CARDIAC
ARREST.
Medical Cond Aggravated by Exposure:N/D. DATA FOR BUPIVACAINE
HYDROCHLORIDE SUGGEST PRE-EXISTING CENTRAL NERVOUS SYSTEM OR
CARDIOVASCULAR AILMENTS. HYPERSENSITIVITY TO AMIDE-TYPE LOCAL
ANESTHETICS, TO SYMPATHOMIMETIC AMINES OR BISULFITES
======================= First Aid Measures =======================
First Aid:EYES / SKIN / INGESTION / INHALATION: REMOVE FROM SOURCE OF
EXPOSURE. FLUSH WITH COPIOUS AMOUNTS OF WATER. IF IRRITATION
PERSISTS OR SIGNS OF TOXICITY OCCUR, SEEK MEDICAL ATTENTION. NO
KNOWN ANTIDOTE. PROVIDE SYMPTOMATIC/SUPPORTIVE CARE, MAINTAINING
VENTILATION, CONTROLLING CONVULSIONS, AND MONITORING CARDIOVASCULAR
FUNCTION, AS NECESSARY.
===================== Fire Fighting Measures =====================
Autoignition Temp:Autoignition Temp Text:N/D
Lower Limits:N/D
Upper Limits:N/D
Extinguishing Media:USE MEDIA APPROPRIATE FOR PRIMARY CAUSE OF FIRE.
Fire Fighting Procedures:FIRE FIGHTERS SHOULD WEAR SELF-CONTAINED
BREATHING APPARATUS. FLAME AND CHEMICAL RESISTANT CLOTHING, BOOTS
AND GLOVES.
Unusual Fire/Explosion Hazard:N/D
================== Accidental Release Measures ==================
Spill Release Procedures:ABSORB WITH SUITABLE MATERIAL AND PLACE INTO
CONTAINERS FOR DISPOSAL IN ACCORDANCE WITH LOCAL, STATE AND FEDERAL
REGULATIONS.
====================== Handling and Storage ======================
Handling and Storage Precautions:PROTECT FROM FREEZING. PROTECT FROM
LIGHT. STORE AT CONTROLLED ROOM TEMPERATURE OF 15-30 DEGREES C
(59-86 DEGREES F).
Other Precautions:PROTECT FROM LIGHT. STORE IN CARTON UNTIL READY TO
USE.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:RESPIRATORY PROTECTION IS NOT NEEDED DURING
NORMAL PRODUCT USE.
Ventilation:NO SPECIAL PROVISIONS ARE REQUIRED UNDER NORMAL PRODUCT
USE.
Protective Gloves:RECOMMENDED
Eye Protection:NOT REQUIRED DURING TYPICAL USE CONDITIONS.
Other Protective Equipment:EYE PROTECTION IS RECOMMENDED IF CONTACT IS
LIKELY.
Supplemental Safety and Health
LIST NUMBERS: 9041, 9042, 9043, 9044, 9045, 9046, 9047.
================== Physical/Chemical Properties ==================
HCC:T6
Boiling Pt:B.P. Text:WATER APPROX
Melt/Freeze Pt:M.P/F.P Text:WATER APPROX
Vapor Pres:N/D
Vapor Density:N/D
Spec Gravity:1.004GM/L@25C
pH:3.5-5.5
Viscosity:0.97-1.01CPS
Evaporation Rate & Reference:N/D
Solubility in Water:WATER
Appearance and Odor:CLEAR SOLUTION; ODOR N/D
================= Stability and Reactivity Data =================
N/D
Hazardous Decomposition Products:WHEN HEATED TO DECOMPOSITION IT EMITS
TOXIC FUMES OF NOX.
=================== Toxicological Information ===================
Toxicological Information:ORAL TOXICITY: LD50=18 MG/KG IN RABBITS FOR
BUPIVACAINE HYDROCHLOTIDE (HIGHLY TOXIC) LD50=24-50 MG/KG IN MICE &
RATS FOR EPINEPHRINE (HIGHLY TOXIC). DERMAL TOXICITY: CONVULSIONS
REPORTED FOLLOWING DER MAL APPLICATION TO THE SCALP OF 750 MG FOR
BUPIVACAINE HYDROCHLORIDE. LD50=62 MG/KG IN RATS FOR EPINEPHRINE
(HIGHLY TOXIC). INHALATION TOXICITY: LD50(INTRATRACHEAL)=11 MG/KG
IN RABBITS FOR BUPIVACAINE HYDROCHLORIDE. CLINICAL EFFECTS
PRODUCED BY ORAL/INHALATION ADMINISTRATION OF 0.16 MG OR MORE FOR
EPINEPHRINE.
===================== Ecological Information =====================
Ecological:ECOLOGICAL INFORMATION: N.D.
==================== Disposal Considerations ====================
Waste Disposal Methods:DISPOSE OF IN ACCORDANCE WITH LOCAL, STATE AND
FEDERAL REGULATIONS.
=================== MSDS Transport Information ===================
Transport Information:DOT STATUS: NOT REGULATED. IATA/ICAO STATUS: NOT
REGULATED. IMO STATUS: NOT REGULATED.
===================== Regulatory Information =====================
SARA Title III Information:SARA STATUS: NOT LISTED.
Federal Regulatory Information:TSCA: N/A. CERCLA: NOT LISTED. RCRA: NOT
LISTED.
State Regulatory Information:PROP 65 (CA): N/D.
======================= Other Information =======================
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
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