Valid 11/2002 - 01/2003
Sigma Chemical Co.
P.O. Box 14508
St. Louis, MO 63178 USA
Phone: 314-771-5765
MATERIAL SAFETY DATA SHEET
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: T5125
NAME: THIMEROSAL
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 54-64-8
MF: C9H9HGNAO2S
EC NO: 200-210-4
SYNONYMS
((O-CARBOXYPHENYL)THIO)ETHYLMERCURY SODIUM SALT * ELICIDE * ETHYL(2-) TjETBT/PjCourier
ACID SODIUM SALT * ETHYLMERCURITHIOSALICYLIC ACID SODIUM SALT *
ETHYLMERKURITHIOSALICILAN SODNY (CZECH) * ETHYL (SODIUM O-) TjETBT/PjCourier 10 Tf72 47
MERTHIOLATE SODIUM * MERTORGAN * MERZONIN * MERZONIN SODIUM * SET *
SODIUM ETHYLMERCURIC THIOSALICYLATE * SODIUM O-(ETHYLMERCURITHIO)
BENZOATE * SODIUM ETHYLMERCURITHIOSALICYLATE * SODIUM MERTHIOLATE *
THIMEROSAL * THIMEROSALATE * THIOMERSAL * THIOMERSALATE *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
HIGHLY TOXIC (USA)
VERY TOXIC (EU)
VERY TOXIC BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
DANGER OF CUMULATIVE EFFECTS.
MAY CAUSE SENSITIZATION BY INHALATION AND SKIN CONTACT.
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
CALIF. PROP. 65 REPRODUCTIVE HAZARD.
TARGET ORGAN(S):
NERVES
KIDNEYS
SENSITIZER.
CAUSES IRRITATION.
KEEP AWAY FROM FOOD, DRINK AND ANIMAL FEEDINGSTUFFS.
AFTER CONTACT WITH SKIN, WASH IMMEDIATELY WITH PLENTY OF WATER.
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
WEAR SUITABLE PROTECTIVE CLOTHING.
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN IMMEDIATELY.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND
SHOES. CALL A PHYSICIAN.
IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING
THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
WATER SPRAY.
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
THIS MATERIAL, LIKE MOST MATERIALS IN POWDER FORM, IS CAPABLE OF
CREATING A DUST EXPLOSION.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
AVOID RAISING DUST.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
EVACUATE AREA.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
SAFETY SHOWER AND EYE BATH.
USE ONLY IN A CHEMICAL FUME HOOD.
WASH CONTAMINATED CLOTHING BEFORE REUSE.
WASH THOROUGHLY AFTER HANDLING.
DO NOT BREATHE DUST.
DO NOT GET IN EYES, ON SKIN, ON CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
NIOSH/MSHA-APPROVED RESPIRATOR.
COMPATIBLE CHEMICAL-RESISTANT GLOVES.
CHEMICAL SAFETY GOGGLES.
KEEP TIGHTLY CLOSED.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
SOLID.
PHYSICAL PROPERTIES
MELTING POINT: 234 C
FLASHPOINT >482F
>250C
SOLUBILITY:
WATER -Z1076
SPECIFIC GRAVITY: 0,5 G
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
STABILITY
STABLE.
CONDITIONS TO AVOID
MAY DISCOLOR ON EXPOSURE TO LIGHT.
INCOMPATIBILITIES
STRONG OXIDIZING AGENTS
STRONG ACIDS
STRONG BASES
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
CARBON MONOXIDE, CARBON DIOXIDE
MERCURY/MERCURY OXIDES
SULFUR OXIDES
HAZARDOUS POLYMERIZATION
WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
CAUSES SKIN IRRITATION.
MAY BE FATAL IF ABSORBED THROUGH SKIN.
CAUSES EYE IRRITATION.
MAY BE FATAL IF INHALED.
MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
MAY BE FATAL IF SWALLOWED.
POSSIBLE ALLERGIC REACTION TO DUST IF INHALED, INGESTED OR IN CONTACT
WITH THE SKIN. HYPERSENSITIVITY REACTIONS MANIFESTED BY ERYTHEMA,
PAPULAR OR VESICULAR ERUPTIONS OCCUR OCCASIONALLY. ALLERGIC
CONJUNCTIVITIS HAS BEEN REPORTED.
TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
CHRONIC EFFECTS
TARGET ORGAN(S):
NERVES
KIDNEYS
RTECS #: OV8400000
MERCURY, ((O-CARBOXYPHENYL)THIO)ETHYL-, SODIUM SALT
IRRITATION DATA
EYE-RBT 8 UG MLD AJOPAA 78,98,1974
TOXICITY DATA
IAL-CHD LDLO:60 MG/KG/4W-I JOPDAB 104,311,1984
ORL-RAT LD50:75 MG/KG PCOC** -,1130,1966
SCU-RAT LD50:98 MG/KG CTOXAO 4,185,1971
UNR-RAT LD50:40 MG/KG 30ZDA9 -,290,1971
ORL-MUS LD50:91 MG/KG NYKZAU 58,235,1962
IPR-MUS LD50:54 MG/KG NYKZAU 58,235,1962
SCU-MUS LD50:66 MG/KG QJPPAL 12,212,1939
IVN-MUS LD50:45 MG/KG QJPPAL 12,212,1939
TARGET ORGAN DATA
BRAIN AND COVERINGS (OTHER DEGENERATIVE CHANGES)
BEHAVIORAL (ANOREXIA, HUMAN)
BEHAVIORAL (CHANGE IN MOTOR ACTIVITY)
BEHAVIORAL (ATAXIA)
BEHAVIORAL (COMA)
LUNGS, THORAX OR RESPIRATION (OTHER CHANGES)
GASTROINTESTINAL (NAUSEA OR VOMITING)
KIDNEY, URETER, BLADDER (CHANGES IN TUBULES)
EFFECTS ON FERTILITY (POST-IMPLANTATION MORTALITY)
EFFECTS ON FERTILITY (ABORTION)
EFFECTS ON EMBRYO OR FETUS (FETAL DEATH)
TUMORIGENIC EFFECTS (UTERINE TUMORS)
NUTRITIONAL AND GROSS METABOLIC (CHANGES IN: METABOLIC ACIDOSIS)
TUMORIGENIC (NEOPLASTIC BY RTECS CRITERIA)
TUMORIGENIC (TUMORS AT SITE OF APPLICATION)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE OF
THIS MATERIAL.
DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
EC INDEX NO: 080-004-00-7
VERY TOXIC
R 26/27/28
VERY TOXIC BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
R 33
DANGER OF CUMULATIVE EFFECTS.
R 50/53
VERY TOXIC TO AQUATIC ORGANISMS, MAY CAUSE LONG-TERM ADVERSE
EFFECTS IN THE AQUATIC ENVIRONMENT.
S 13
KEEP AWAY FROM FOOD, DRINK AND ANIMAL FEEDINGSTUFFS.
S 28
AFTER CONTACT WITH SKIN, WASH IMMEDIATELY WITH PLENTY OF SOAP SUDS.
S 36
WEAR SUITABLE PROTECTIVE CLOTHING.
S 45
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
S 60
THIS MATERIAL AND ITS CONTAINER MUST BE DISPOSED OF AS
HAZARDOUS WASTE.
S 61
AVOID RELEASE TO THE ENVIRONMENT. REFER TO SPECIAL INSTRUCTIONS/
SAFETY DATA SHEETS.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
ACGIH TLV-TWA 0.1 MG(HG)/M3 (SKIN) DTLVS* TLV/BEI,1999
MSHA STANDARD-AIR:TWA 0.05 MG(HG)/M3
DTLWS* 3,22,1973
OSHA PEL (GEN INDU):8H TWA 0.01 MG(HG)/M3
CFRGBR 29,1910.1000,1994
OSHA PEL (CONSTRUC):8H TWA 0.01 MG(HG)/M3 (SKIN)
CFRGBR 29,1926.55,1994
OSHA PEL (SHIPYARD):8H TWA 0.01 MG(HG)/M3 (SKIN)
CFRGBR 29,1915.1000,1993
OSHA PEL (FED CONT):8H TWA 0.01 MG(HG)/M3 (SKIN)
CFRGBR 41,50-204.50,1994
OEL-AUSTRALIA: TWA 0.05 MG(HG)/M3, SKIN, JAN1993
OEL-BELGIUM: TWA 0.05 MG(HG)/M3, SKIN, JAN1993
OEL-DENMARK: TWA 0.05 MG(HG)/M3, SKIN, JAN1999
OEL-FINLAND: TWA 1 MG(HG)/M3, JAN1999
OEL-FRANCE: VME 0.1 MG(HG)/M3, JAN1999
OEL-GERMANY: MAK 0.01 PPM (0.1 MG(HG)/M3), JAN1999
OEL-HUNGARY: TWA 0.02 MG(HG)/M3, STEL 0.04 MG(HG)/M3, JAN1993
OEL-JAPAN: OEL 0.05 MG(HG)/M3, JAN1999
OEL-THE NETHERLANDS: MAC-TGG O.05 MG(HG)/M3, MAC-K 0.15 MG(HG)/M3,
SKIN, JAN1999
OEL-NORWAY: TWA 0.05 MG(HG)/M3, JAN1999
OEL-THE PHILIPPINES: TWA 0.05 MG(HG)/M3, JAN1993
OEL-POLAND: MAC(TWA) 0.05 MG(HG)/M3, MAC(STEL) 0.15 MG(HG)/M3, JAN1999
OEL-RUSSIA: TWA 0.05 MG(HG)/M3, STEL 0.01 MG(HG)/M3, JAN1993
OEL-SWEDEN: NGV 0.05 MG(HG)/M3, SKIN, JAN1999
OEL-THAILAND: STEL 0.05 MG(HG)/M3, JAN1993
OEL-UNITED KINGDOM: LTEL 0.05 MG(HG)/M3, STEL 0.15 MG(HG)/M3, JAN1993
OEL IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA CHECK ACGIH TLV;
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM CHECK ACGIH TLV
NIOSH REL TO MERCURY, ARYL AND INORGANIC-AIR:CL 0.1 MG/M3 (SK)
NIOSH* DHHS #92-100,1992
NOHS 1974: HZD 84569; NIS 83; TNF 5617; NOS 30; TNE 242717
NOES 1983: HZD 84569; NIS 32; TNF 3695; NOS 41; TNE 152997; TFE 114190
EPA GENETOX PROGRAM 1988, POSITIVE: S CEREVISIAE GENE CONVERSION
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
U.S. INFORMATION
THIS PRODUCT IS SUBJECT TO SARA SECTION 313 REPORTING REQUIREMENTS -
MERCURY COMPOUNDS.
THIS PRODUCT IS OR CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF
CALIFORNIA TO CAUSE DEVELOPMENTAL TOXICITY.
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 2001 SIGMA-ALDRICH CO.
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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