MATERIAL SAFETY DATA SHEET
REILLY INDUSTRIES, INC.
庐
SECTION 1: CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
Product Name: 4-Dimethylaminopyridine
Chemical Name: 4-Pyridinamine, N,N-dimethyl- Synonyms: Pyridine, 4-dimethylamino-; DMAP; 4-DMAP;
N,N-Dimethyl-4-aminopyridine
CAS Number: 1122-58-3 Product Use: chemical intermediate
Manufacturer Information: Reilly Industries, Inc. Emergency Phone Number (24 hr.): (317) 247-8141
300 North Meridian Street CHEMTREC Phone Number (24 hr.): (800) 424-9300
Suite 1500 (collect calls are accepted)
Indianapolis, Indiana 46204 Non-Emergency Phone Number: (317) 247-8141
USA Non-Emergency Fax Number: (317) 248-6413
SECTION 2: COMPOSITION AND INFORMATION ON INGREDIENTS
Exposure Limits
Ingredient CAS Number Concentration (%) OSHA PEL ACGIH TLV
4-Dimethylaminopyridine 1122-58-3 approx. 100% not established not established
SECTION 3: HAZARDS IDENTIFICATION
Emergency Overview:
A white, odorless solid. Highly toxic via dermal exposure. Toxic via oral exposure. Severely irritating to tissue
(nearly corrosive).
Signs and Symptoms of Potential Overexposure: DMAP is irritating to the respiratory tract and severely irritating (borderline
corrosive) to the eye and eyelids. Absorption can occur form the gastrointestinal
tract, the skin, and the respiratory tract. Although data on inhalation toxicity are
unavailable, it may be assumed that this material is toxic via inhalation.
Symptoms of overexposure may include headache, nausea, disorientation,
weakness, and convulsions. DMAP is HIGHLY TOXIC via the dermal route.
Extended contact with this material could be fatal. More than ordinary care
should be used to prevent skin and eye contact. This material is considered to
be toxic via the oral route. Symptoms of poisoning are expected to be essentially
the same as those listed previously. Ingestion is not likely to be a primary route
of exposure.
Primary Route(s) of Entry: Skin contact, skin absorption, eye contact, inhalation, ingestion.
Medical Conditions Aggravated by Exposure: Persons with pre-existing skin, liver, or kidney disorders may be at increased risk
from overexposure to this material. This is not likely to be a problem when
appropriate procedures are used to minimize exposure.
SECTION 4: FIRST AID MEASURES
Skin Contact: Wash exposed area twice with soap and water. The exposed area should be examined by medical
personnel. Due to this material's dermal toxicity, it is important to wash the exposed area without delay and
GET MEDICAL ATTENTION as soon as possible.
Eye Contact: Rinse eyes immediately with large amounts of water for at least 15 minutes, occasionally lifting the eyelids.
GET MEDICAL ATTENTION.
Inhalation: Remove from exposure area to fresh air immediately. If breathing has stopped, give artificial respiration.
Keep affected person warm and at rest. GET MEDICAL ATTENTION.
Ingestion: If conscious, induce vomiting to prevent further absorption. Give oxygen if respiration is shallow. GET
MEDICAL ATTENTION. Do not give anything by mouth to an unconscious person. Due to this material's
high toxicity, it is essential to get medical attention as quickly as possible.
Thermal Exposure: not applicable
Delayed Effects: This material is readily absorbed from the gastrointestinal tract, the skin, and the respiratory tract. Extended
contact with this material could be fatal.
MATERIAL SAFETY DATA SHEET Product Name: 4-Dimethylaminopyridine
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Note to Physician: This material is highly toxic via dermal exposure and is readily absorbed through the skin. Rapid, complete
decontamination of the patient is critical (material is slightly water-soluble). No specific antidote known. This
material may induce methemoglobin formation. Treatment should be based on the judgment of the physician
in response to the reactions of the patient.
SECTION 5: FIRE FIGHTING MEASURES
Flash Point: 230 F (110 C) Method: TOC Autoignition Temperature: 788掳F (420掳C)
Flammable Limits: UFL : not available LFL: not available
Flammability Classification (OSHA): Not applicable.
Hazardous Products of Combustion: Toxic vapors may be released upon thermal decomposition (cyanides, nitrogen
oxides, carbon monoxide).
Potential for Dust Explosion: not available
Special Flammability Hazards: not applicable
Appropriate Extinguishing Media: Water fog, foam, carbon dioxide, dry chemical
Basic Fire Fighting Guidance: Wear self-contained breathing apparatus and full protective clothing. Skin and eye
contact must be avoided due to high toxicity. Normal fire fighting procedures may be
used.
SECTION 6: ACCIDENTAL RELEASE MEASURES
Containment Techniques: Sweep or scoop up the spilled material and place in a disposal container.
Clean-up Procedures & Wear protective equipment during clean-up. Remove all ignition sources. Ventilate area of spill or leak.
Equipment: Collect material for later disposal. After collection of product, flush area with water.
Evacuation Procedures: Isolate the hazard area and deny entry to unnecessary and unprotected personnel.
Special Instructions: Avoid dust generation during clean up. Ensure thorough decontamination of the release area and clean-
up personnel.
Special Reporting Requirements: Notify appropriate authorities if required by regulation.
SECTION 7: HANDLING AND STORAGE
Storage Precautions: Protect containers from physical damage, sparks and flames.
Storage Recommendations: Outside or detached storage is preferable. Maintain dry, ventilated conditions for storage. Containers
should be periodically inspected. Recommended storage temperature not to exceed 75掳F (24掳C) to
maintain product flowability.
Precautions for Unique Hazards: not applicable
Practices to Minimize Risk: Wear appropriate protective equipment when performing maintenance on contaminated equipment.
Special Handling Equipment: See Personal Protective Equipment recommendations.
Dangerous Incompatibility Keep away from strong acids and oxidizing agents.
Reactions:
Incompatibilities with Materials of none known
Construction:
SECTION 8: EXPOSURE CONTROLS AND PERSONAL PROTECTION
Exposure Limits: OSHA PEL: Not established ACGIH TLV: Not established
Personal Protective Equipment: For handling small quantities outside a laboratory setting: NIOSH-approved full-face chemical
cartridge respirator with organic vapor cartridges and HEPA filters; impervious gloves (nitrile or
neoprene), poly-coated Tyvek庐 coveralls, rubber boots, and face shield as necessary. For
handling large quantities: supplied air breathing equipment; impervious gloves (nitrile or
neoprene), Saranex庐 coveralls, rubber boots, and face shield as necessary. Laboratory
handling should be done per prudent safe laboratory practices, taking extra precaution to
MATERIAL SAFETY DATA SHEET Product Name: 4-Dimethylaminopyridine
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prevent inhalation or skin/eye contact.
Respirator Caution: Observe OSHA regulations for respirator use (29 CFR 1910.134). Air-purifying respirators must
not be used in oxygen-deficient atmospheres.
Ventilation: All operations should be conducted in well-ventilated conditions. Local exhaust ventilation
should be provided.
Other Engineering Controls: All appropriate engineering controls should be used to minimize exposure potential.
Thermal Hazards: not applicable
Additive or Synergistic Effects: none known
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
Molecular Formula: C7H10N2
Molecular Weight: 122.17
Appearance, State & Odor White odorless solid
(ambient temperature):
pH: 11 (as 60 g/L water solution @ 20掳C)
Vapor Pressure: < 1 mm Hg @ 25掳C
Vapor Density (air = 1): not available
Boiling Point: 162 掳C @ 50 mm Hg
Freezing Point: 111.6 C
Melting Point: 112 C
Solubility in Water: 7.6 g in 100 mL H20 @ 25掳C
Specific Gravity or Density: 0.96 g/mL @ 112掳C
VOC Content: not available
Bulk Density: 0.66 kg/L
Octanol / Water Partition 1.34
Coefficient:
Odor Threshold: not available
SECTION 10: STABILITY AND REACTIVITY
Chemical Stability: Stable
Conditions to Avoid: not applicable
Incompatibilities: Strong acids, oxidizing agents.
Hazardous Decomposition Products: not applicable
Hazardous Polymerization: will not occur
SECTION 11: TOXICOLOGICAL INFORMATION
Acute Oral LD50: 140 mg/kg Species: Rat
Acute Dermal LD50: 90 mg/kg Species: Rabbit
Acute Inhalation LC50: not available Duration: not available Species: not available
Skin / Eye Irritation: Severe skin irritant / Severe eye irritant
Target Organs: No data available.
Carcinogenicity: No data available.
Teratogenicity: No data available.
MATERIAL SAFETY DATA SHEET Product Name: 4-Dimethylaminopyridine
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Reproductive Effects: No data available.
Neurotoxicity: DMAP has been shown to exert a weak antagonistic effect of very short duration on d-tubocurarine-induced
neuromuscular blocks in laboratory tests with rat tissues. DMAP has also been shown to induce muscle
contractions in laboratory tests with rat cardiac muscle.
Mutagenicity: Negative for mutagenic effect in Ames test using multiple strains of Salmonella tymphimurium, both with and
without metabolic activation.
Additional Toxicity Information: DMAP has been tested specifically for corrosivity using US DOT guidelines. It was found to be non-
corrosive, although DMAP is severely irritating to the skin and eyes. Some laboratory studies suggest that
DMAP may slowly induce formation of methemoglobin.
SECTION 12: ECOLOGICAL INFORMATION
Ecotoxicity: Daphnia magna: LC50 (48 hr) > 100 mg/L
Fish (Brachydanio rerio): LC50 (96 hr) = 11.60 mg/L; NOEC = 5 mg/L
Algae (Pseudokirchneriella subcapitata): EC50 (biomass, 72 hr) = 1.82 mg/L; EC50 (growth rate, 72 hr) = 4.22 mg/L;
NOEC (72 hr) = 0.4 mg/L
Environmental Fate: Based on structure-activity relationships, this material is expected to biodegrade, though perhaps slowly (weeks to
months).
SECTION 13: DISPOSAL CONSIDERATIONS
US EPA Waste Number: not applicable
Classification of Waste as Manufactured: Non Hazardous
(per federal regulations) NOTE: Generator is responsible for proper waste characterization. State hazardous
waste regulations may differ substantially from federal regulations.
Waste Disposal: Dispose of this material in accordance with standard practice for disposal of potentially hazardous materials as
required by applicable federal, state or local laws. Note that disposal regulations may also apply to empty
containers and equipment rinsates.
SECTION 14: TRANSPORT INFORMATION
DOT Proper Shipping Name: Toxic Solid, Organic, n.o.s., (4-Dimethylaminopyridine), 6.1, UN2811, PG II
IATA Proper Shipping Name: Toxic Solid, Organic, n.o.s., (4-Dimethylaminopyridine), 6.1, UN2811, PG II
IMDG Proper Shipping Name: Toxic Solid, Organic, n.o.s., (4-Dimethylaminopyridine), 6.1, UN2811, PG II
Emergency Guidebook Numbers: NAERG: 154 EMS: 6.1-04 MFAG: 325
SECTION 15: REGULATORY INFORMATION
OSHA Hazards: Highly toxic (dermal). Toxic (oral). Severely irritating to skin and eyes.
Chemical Inventory Status: TSCA: Yes EINECS: Yes Canada: Yes - DSL
Japan: Yes Korea: Yes Australia: Yes
China: Yes Philippines: Yes
SARA 313: not applicable
Other Regulatory Listings: Class D Division 1 Subdivision B: Toxic Material
Class D Division 2 Subdivision B: Irritant
Reportable Quantities: not applicable
State Regulations: not applicable
MATERIAL SAFETY DATA SHEET Product Name: 4-Dimethylaminopyridine
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SECTION 16: OTHER INFORMATION
Precautionary Statement: Please note that the information contained herein is furnished without warranty of any kind. Users should consider
these data only as a supplement to other information gathered by them and must make independent determinations of suitability and completeness
of information from all sources to assure proper use and disposal of these materials and the safety and health of employees and customers.
Reilly Industries Hazard Rating System: H: 3 F: 1 R: 0
Revision Date: 05 August 2002 Original Date of Issue: 04 April 1985
Revision Details: Revised formatting.
Revised data in Sections 3, 4, 5, 7, 9, 11, 12
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