PRODUCT #: A5882 NAME: ANTIPYRINE CRYSTALLINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 1:45PM
Sigma Chemical Co. Aldrich Chemical Co., Inc. Fluka Chemical Corp.
P.O. Box 14508 1001 West St. Paul 1001 West St. Paul
St. Louis, MO 63178 Milwaukee, WI 53233 Milwaukee, WI 53233
Phone: 314-771-5765 Phone: 414-273-3850 Phone: 414-273-3850
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: A5882
NAME: ANTIPYRINE CRYSTALLINE
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 60-80-0
MF: C11H12N2O
EC NO: 200-486-6
SYNONYMS
ANALGESINE * ANODYNIN * ANODYNINE * ANTIPIRIN * ANTIPYRIN * APIRELINA
* AZOPHEN * AZOPHENE * 1,2-DIHYDRO-1,5-DIMETHYL-2-PHENYL-3H-PYRAZOL-3-
ONE * DIMETHYLOXYCHINIZIN * DIMETHYLOXYQUINAZINE * 2,3-DIMETHYL-1-
PHENYL-3-PYRAZOLIN-5-ONE * 2,3-DIMETHYL-1-PHENYL-5-PYRAZOLONE *
FENAZON (CZECH) * FENAZONE * METHOZIN * OXYDIMETHYLQUINAZINE *
PARODYNE * PHENAZON * PHENAZONE * PHENAZONUM * PHENOZONE * PHENAZONE
(PHARMACEUTICAL) * 1-PHENYL-2,3-DIMETHYLPYRAZOLE-5-ONE * 1-PHENYL-2,3-
DIMETHYL-5-PYRAZOLONE * PHENYLON * PHENYLONE * PYRAZOPHYL * 3H-
PYRAZOL-3-ONE, 1,2-DIHYDRO-1,5-DIMETHYL-2-PHENYL- (9CI) * SEDATIN *
SEDATINE *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
HARMFUL
HARMFUL IF SWALLOWED.
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
MAY CAUSE SENSITIZATION BY SKIN CONTACT.
TARGET ORGAN(S):
BLOOD
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
WEAR SUITABLE PROTECTIVE CLOTHING.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS AMOUNTS OF
WATER FOR AT LEAST 15 MINUTES.
IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS
AMOUNTS OF WATER.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
WASH CONTAMINATED CLOTHING BEFORE REUSE.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
WATER SPRAY.
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
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PRODUCT #: A5882 NAME: ANTIPYRINE CRYSTALLINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 1:45PM
WEAR RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
AVOID RAISING DUST.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
CHEMICAL SAFETY GOGGLES.
COMPATIBLE CHEMICAL-RESISTANT GLOVES.
NIOSH/MSHA-APPROVED RESPIRATOR.
SAFETY SHOWER AND EYE BATH.
MECHANICAL EXHAUST REQUIRED.
AVOID INHALATION.
AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
WASH THOROUGHLY AFTER HANDLING.
HARMFUL SOLID.
SENSITIZER.
KEEP TIGHTLY CLOSED.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
WHITE CRYSTALLINE POWDER
PHYSICAL PROPERTIES
MELTING POINT: 111 C TO 114 C
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
INCOMPATIBILITIES
STRONG OXIDIZING AGENTS
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
TOXIC FUMES OF:
CARBON MONOXIDE, CARBON DIOXIDE
NITROGEN OXIDES
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
HARMFUL IF SWALLOWED.
MAY BE HARMFUL IF INHALED.
MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
CAUSES EYE AND SKIN IRRITATION.
MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
MAY CAUSE ALLERGIC SKIN REACTION.
TARGET ORGAN(S):
BLOOD
RTECS #: CD2450000
ANTIPYRINE
TOXICITY DATA
UNR-MAN LDLO:74 MG/KG 85DCAI 2,73,1970
ORL-RAT LD50:1705 MG/KG ARZNAD 9,401,1959
ORL-MUS LD50:1310 MG/KG JAPMA8 45,137,1956
IPR-MUS LD50:750 MG/KG AIPTAK 135,376,1962
SCU-MUS LD50:1 GM/KG ARZNAD 17,214,1967
IVN-MUS LD50:500 MG/KG ARZNAD 10,686,1960
TARGET ORGAN DATA
SENSE ORGANS AND SPECIAL SENSES (MYDRIASIS)
AUTONOMIC NERVOUS SYSTEM (OTHER: PARASYMPATHOMIMETIC)
BEHAVIORAL (CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD)
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PRODUCT #: A5882 NAME: ANTIPYRINE CRYSTALLINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 1:45PM
CARDIAC (PULSE RATE DECREASED WITH FALL IN BP)
CARDIAC (OTHER CHANGES)
LUNGS, THORAX OR RESPIRATION (RESPIRATORY DEPRESSION)
GASTROINTESTINAL (NAUSEA OR VOMITING)
NUTRITIONAL AND GROSS METABOLIC (BODY TEMPERATURE DECREASE)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
HARMFUL
R 22
HARMFUL IF SWALLOWED.
R 36/37/38
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
R 43
MAY CAUSE SENSITIZATION BY SKIN CONTACT.
S 26
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
S 36
WEAR SUITABLE PROTECTIVE CLOTHING.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
NOHS 1974: HZD 07420; NIS 3; TNF 41; NOS 3; TNE 739
NOES 1983: HZD 07420; NIS 4; TNF 163; NOS 7; TNE 1907; TFE 1486
EPA GENETOX PROGRAM 1988, NEGATIVE: HISTIDINE REVERSION-AMES TEST
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 1997 SIGMA CHEMICAL CO., ALDRICH CHEMICAL CO., INC.,
FLUKA CHEMIE AG
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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