Material Safety Data Sheet
Authorization date: 07/26/1999
Revision date: 08/22/2006
Print Date: 08/24/2006
Version: 0
1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING
Product name: 5 BROMO-4-CHLORO-3-INDOLYL-PHOSPHATE
Product number: 1585002
Global material number: 11585002001
Business area: Roche Applied Sciences
Product line: Not applicable
Instrument type: Not applicable
Supplier: Emergency telephone number:
Roche Diagnostics Corporation CHEMTREC:
9115 Hague Road 1-800-424-9300 (U.S. or Canada)
Indianapolis, IN 46250 1-703-527-3887 (International)
Site Phone Number: 1-800-428-5074
2. COMPOSITION/INFORMATION ON INGREDIENTS
Description 1: Bottle 1
Components CAS Number Weight % OSHA PEL: OSHA STEL: ACGIH TLV: ACGIH STEL:
5-Bromo-4-chloro-3-indolyl 540-23-8 20-30 NA NA NA NA
phosphate, 4-toluidine salt
3. HAZARDS IDENTIFICATION
Emergency Overview
NFPA Ratings: Health= 3 Flammability= 0 Reactivity= 0 Special= CA
Special Definitions: A=Allergen CA=Carcinogen CO=Corrosive F=Flammable H=Harmful I=Irritant Ox=Oxidizer PB=Potential Biohazard
R=Reproductive S=Sensitizer T=Toxic T+=Highly Toxic W=Water Reactive
Principle routes of exposure: Ingestion, skin and/or eye contact.
Inhalation: None.
Ingestion: Ingestion may cause gastrointestinal irritation, nausea, vomiting and diarrhea.
Skin contact: None.
Eye contact: May cause irritation.
Sensitization or Odor threshold: None.
Medical conditions aggravated by None known
exposure:
Additional information: None
4. FIRST AID MEASURES
Inhalation: Consult a physician. Move to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give
oxygen.
Skin contact: Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Ingestion: Call a physician immediately. Do not induce vomiting without medical advice. Drink 1 or 2 glasses of water.
Eye contact: Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Notes to physician: None determined
5. FIRE-FIGHTING MEASURES
5. FIRE-FIGHTING MEASURES
Suitable extinguishing media: Use dry chemical, CO2, water spray or "alcohol" foam.
Unusual hazards: None known.
Special protective equipment for In the event of fire, wear self-contained breathing apparatus.
firefighters:
6. ACCIDENTAL RELEASE MEASURES
Personal precautions: Use personal protective equipment. Evacuate personnel to safe areas. Remove all sources of ignition.
Avoid dust formation. Ensure adequate ventilation.
Environmental precautions: Prevent further leakage or spillage if safe to do so. Prevent product from entering drains. Do not flush into
surface water or sanitary sewer system. Do not let product enter drains.
Methods for cleaning up: Never return spills in original containers for re-use. Soak up with oil absorbent material. Sweep up or
vacuum (if powder) or soak up with inert absorbent material (if liquid), then place into a suitable clean, dry,
closed container, and label for disposal.
7. HANDLING AND STORAGE
Handling: Protect from contamination. Wear personal protective equipment.
Storage: Keep containers dry and tightly closed to avoid moisture absorption and contamination.
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering measures: Not applicable.
Personal Protective Equipment
Respiratory protection: Respiratory protection is not required under normal use of this product. If respiratory protection is needed,
follow the OSHA regulation, 29CFR1910.134. Always use a NIOSH approved respirator when necessary.
Hand protection: Wear appropriate protective gloves to prevent skin contact. Replace torn or punctured gloves promptly.
Skin and body protection: Wear appropriate body protection to prevent skin contact.
Eye protection: Wear appropriate eye protection to prevent eye contact.
Hygiene measures: When using, do not eat, drink or smoke. Keep away from food and drink. Keep away from tobacco
products. Wash hands before breaks and immediately after handling the product. Handle in accordance
with good industrial hygiene and safety practice for diagnostics.
9. PHYSICAL AND CHEMICAL PROPERTIES
Boiling point/range: No information available
Melting point/range: Not determined
pH: Not determined
Physical state: Powder.
Flash point: No information available.
LEL (%): Not determined
UEL (%): Not determined
10. STABILITY AND REACTIVITY
Stability: Stable under recommended storage conditions.
Polymerization: None under normal processing.
Hazardous decomposition products: None reasonably foreseeable.
Materials to avoid: No data available.
11. TOXICOLOGICAL INFORMATION
Description 1: Bottle 1
Components NIOSH - NIOSH Pocket Guide -
Selected LD50s and LC50s: Target Organs:
5-Bromo-4-chloro-3-indolyl = 1285 mg/kg Oral LD50 Rat
phosphate, 4-toluidine salt
Inhalation: No additional data available
Product number: 1585002 Page 2 of 4
Product name: 5 BROMO-4-CHLORO-3-INDOLYL-PHOSPHATE
Skin: No additional data available
Oral: No additional data available
Mutagenic effects: No data is available on the product itself
Reproductive toxicity: No data is available on the product itself
Carcinogenic effects:
12. ECOLOGICAL INFORMATION
Bioaccumulation: No data available
Aquatic toxicity: Not applicable
Ecotoxicity effects: No data is available on the product itself
13. DISPOSAL CONSIDERATIONS
Waste from residues / unused products: Waste disposal must be in accordance with appropriate Federal, State, and local regulations. This product,
if unaltered by use, may be disposed of by treatment at a permitted facility or as advised by your local
hazardous waste regulatory authority. Residue from fires extinguished with this material may be
hazardous.
14. TRANSPORT INFORMATION
Is product hazardous to ship? No
DOT
Proper shipping name: None
UN Number: Not applicable Hazard class: Not applicable Subsidiary risk: Not applicable Packing group: Not applicable
ICAO/IATA
Proper shipping name: None
UN Number: Not applicable Hazard class: Not applicable Subsidiary risk: Not applicable Packing group: Not applicable
15. REGULATORY INFORMATION
U.S. Regulations:
U.S. CERCLA/SARA/TSCA Regulatory Information: The following chemicals are listed under the following TSCA/SARA/CERCLA lists. Refer to
TSCA regulation if you need a definition for acronyms that may be shown in the TSCA Inventory field in the table below
Components CERCLA/SARA 302 CERCLA/SARA 304 SARA 313 TSCA Inventory
RQ and TPQ RQ Emission reporting
(40 CFR 355, App.A) (40 CFR Table 302.4)
5-Bromo-4-chloro-3-indolyl Present
phosphate, 4-toluidine salt
U.S. Clean Water Act (CWA)/ California The following chemicals are listed under the CWA and/or California Proposition 65:
Proposition 65:
Canadian Regulations:
Canada DSL Inventory List - This product complies with DSL
Canada NDSL Inventory List - This product does not comply with NDSL
Components Canada - WHMIS: Classifications of Substances:
5-Bromo-4-chloro-3-indolyl D2B
phosphate, 4-toluidine salt
16. OTHER INFORMATION
Reason for revision: Not applicable
Product number: 1585002 Page 3 of 4
Product name: 5 BROMO-4-CHLORO-3-INDOLYL-PHOSPHATE
16. OTHER INFORMATION
References: None.
Additional advice: None
Prepared by: Roche Diagnostics, Health & Safety Department, MSDS Contact: 317-521-7425 or 317-521-7505
The information, data and recommendations contained herein are based upon information believed by Roche Diagnostics Corporation, after reasonable investigation and
research, to be accurate; however, Roche Diagnostics Corporation does not warrant the accuracy of this information. All materials and mixtures may present unknown
hazards and should be used with caution. When necessary or appropriate, independent opinions regarding the risk of handling or exposure should be obtained from trained
professionals. Roche Diagnostics Corporation disclaims any warranty against patent infringement and the implied warranties of merchantability and fitness for a particular
purpose. Customer's sole and exclusive remedy shall be replacement of the product or return of the product and refund of the purchase price, at Roche Diagnostics
Corporation's option. In no case shall Roche Diagnostics Corporation be liable for incidental or consequential damages, including lost profits.
End of Safety Data Sheet
Product number: 1585002 Page 4 of 4
Product name: 5 BROMO-4-CHLORO-3-INDOLYL-PHOSPHATE
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