EMS CAT AL OG NO: 23400
EMS PR ODUCT : Xylene
DAT E: 07/ 28/ 2001
PAGE NUMB ER : One of 10
MAT ER I AL S AFET Y DAT A S HEET
T he information contained herein is based on data considered accurate. However, no
warranty is expressed or implied regarding the accuracy of these data or the results to
be obtained from the use thereof.
Electron Microscopy Sciences assumes no responsibility for personal injury or property
damage to vendees, users or third parties caused by the material. Such vendees or
users assume all risks associated with the use of the material.
EL ECT R ON MI CR OS COPY S CI ENCES
321 MOR R I S R OAD
P.O. B OX 251
FOR T W AS HI NGT ON, PA 19034 24 HOUR EMER GENCY PHONE NUMB ER
(215) 646-1566 CHEMT R EC: (800) 424-9300
FOR PR ODUCT AND S AL ES I NFOR MAT I ON
CONT AC ELEC RON MI C
T T ROSCOPY SC ENC OFFI C ABOVE.
I ES E
PR ODUCT I DENT I FI CAT I ON
PRODUC NAME:
T Xylene
C NUMBER:
AS 1330-20-7
T RADE NAMES/SYNONYMS:
Benzene, Dimethyl-; Dilan; Dimethylbenzene; Xylol; Humiseal
T hinner No. 33 (Humiseal Div.); Humiseal T hinner No. SP 420
(Humiseal Div.); Solvesso Xylene (Humble Oil and Refining
C ompany); T T -X-9166 Reducer (Advanced C oatings and Chemicals);
Dynachem (R) Developer DC (T hiokol/Dynachem C
R orporation);
T hinner 2000 (KOP-C oat); Sol 9050 Xylene (Chemtech I ndustries,
I nc.); Humiseal T hinner No. 521 (M.W. Riedel and C ompany); RC RA
U239; ST C 4904350; UN 1307; C
C 8H10; OHS25150
CHEMI C FAMI LY:
AL Hydrocarbon, aromatic
MOLECULAR FORMULA: C6H4(C-H3)2
MOLECULAR WEI G :
HT 106.16
CERC RAT I NG (SC
LA S ALE 0-3): NFPA RAT I NG (SC
S ALE 0-4):
HEALT H: 2 HEALT H: 2
FI RE: 3 FI RE: 3
REAC I VI T Y:
T 0 REAC I VI T Y: 0
T
PERSI ST ENC E: 1
COMPONENT S AND CONT AMI NANT S
COMPONENT : Xylene (O-, M-, P-I somers)
PERC ENT : 100
OT HER CONT AMI NANT S: None
EXPOSURE LI MI T S:
100 ppm (434 mg/m3) OSHA T WA; 150 ppm (651 mg/m3) OSHA ST EL
100 ppm (434 mg/m3) AC I H T WA;150 ppm (651 mg/m3) AC I H ST EL
G G
100 ppm (434 mg/m3) NI OSH recommended T WA
150 ppm (651 mg/m3) NI OSH recommended ST EL
100 ppm (434 mg/m3) DFG MAK T WA
200 ppm (868 mg/m3) DFG MAK 30 minute peak, average value, 4 times/shift
1000 pounds C ERC Section 103 Reportable Quantity subject to
LA
SARA Section 313 annual T oxic Chemical Release reporting.
* * OSHA limits adopted January 19, 1989 are subject to the decision of
the 11th circuit court of appears (ALF-C O V. OSHA as of July 8, 1992.* *
I
PHYS I CAL DAT A
DESC PT I ON:
RI Light colored or colorless mobile liquid with an aromatic odor.
BOI LI NG POI NT : 280-291oF (138-144oC )
MELT I NG POI NT : -54-55oF (-48-13oC )
SPEC FI C G
I RAVI T Y: 0.8611-0.8802
VOLAT I LI T Y: 100%
VAPOR PRESSURE: 7-9 mm Hg at 20oC
EVAPORAT I ON RAT E: 0.6 (Butyl Acetate= 1)
SOLUBI LI T Y I N WAT ER: 0.00003%
ODOR T HRESHOLD: 0.3 ppm
VAPOR DENSI T Y: 3.7
SOLVENT SOLUBI LI T Y: Soluble in alcohol, ether, acetone, petroleum ether, benzene,
carbon tetrachloride, organic solvents.
Catalog # 23400 2
Xylene
FI R E AND EXPL OS I ON DAT A
FI RE AND EXPLOSI ON HAZARD:
Dangerous fire hazard when exposed to heat or flame. Due to low electroconductivity
of the substance, flow or agitation may generate electrostatic charges resulting in
sparks with possible ignition. Vapors are heavier than air and may travel a considerable
distance to a source of ignition and flash back. Vapor-air mixtures are explosive.
81-90oF (27-32oC (C )
FLASH POI NT : )C
UPPER EXPLOSI VE LI MI T : 7%
LOWER EXPLOSI VE LI MI T : 1%
867-984oF (464-529oC
AUT OI G T I ON T EMP.:
NI )
FLAMMABI LI T Y CLASS (OSHA): IC
FI REFI G I NG MEDI A:
HT
Dry chemical, carbon dioxide, water spray or standard foam (1987 Emergency Response
Guidebook, DOT P 5800.4).
For larger fires, use water spray, fog or standard foam (1987 Emergency Response
Guidebook, DOT P, 5800.4).
FI REFI G I NG
HT :
Move container from fire area if you can do it without risk. Apply cooling water to sides
of containers that are exposed to flames until well after fire is out. Stay away from
storage tank ends. Use unmanned hose holder or monitor nozzles, if this is possible
withdraw from area and let fire burn. Withdraw immediately in case of rising sound
from venting safety device or any discoloration of storage tank due to fire (1987
Emergency Response G uidebook, DOT P 5800.4, G uide Page 27).
Extinguish only if flow can be stopped; use water in flooding amounts as fog, solid
streams may spread fire. C containers with flooding quantities of water, apply from
ool
as far a distance as possible. Avoid breathing toxic vapors, keep upwind. Water may be
ineffective (NFPA 325m, Fire Properties of flammable liquids, gases, and volatile solids,
1991.)
T R ANS POR T AT I ON DAT A
DOT HAZARD CLASSI FI C I ON 49C
AT FR172.101: Flammable liquid
DOT LABELI NG REQUI REMENT S 49CFR172.101 AND SUBPART E: Flammable
liquid
DOT PACKAG NG REQUI REMENT S: 49C
I FR173.119 EXC I ONS:
EPT 49CFR173.118
Catalog # 23400 3
Xylene
Final rule on hazardous materials regulations (HMR, 49C Parts 171-180). Docket
FR
numbers HM-181, HM-181A, HM-1818, HM-181C HM-181D and HM-204. Effective date
,
October 1, 1991. However, C ompliance with the regulations is authorized on and after
January 1, 1991. (55 FR 52402. 12/21/90).
Except for explosives, I nhalation Hazards and I nfectious Substances, the effective date
for Hazard Communication requirements is extended to October 1, 1993.
DOT I D NO: UN 1307
DOT HAZARD C LASS: 3 - Flammable Liquid
DOT PAC KAG NG G
I ROUP: PG I I
DOT LABELI NG REQ: Flammable Liquid
DOT PACKAG NG AUT HORI ZAT I ONS: EXC I ONS 49C
I EPT FR173.150
NON BULK PAC KAG NG 49C
I: FR173.202
BULK PACKAG NG 49C
I: FR173.242
US DOT QUANT I T Y LI MI T AT I ONS 49CFR172.101: PASSENG AI RC
ER RAFT OR
RAI LCAR: 6 L
CARG AI RC
O RAFT ONLY: 60 L
T OXI CI T Y
I RRI T AT I ON DAT A:
Eye-Rabbit Severe; 100% Skin-Rabbit Moderate: 500 mg/24 hours Skin-Rabbit
Moderate.
T OXI C T Y DAT A:
I
10000 ppm/6 hours inhalation-man LC LO; 200 ppm inhalation-human T C LO; 5000
ppm/4 hours inhalation-rat LC 50; 450 ppm inhalation- guinea pig LCLO; 50 mg/kg oral-
human LDLO; 4300 mg/kg oral-rat LD50; 1700 mg/kg subcutaneous-rat LD50; 2000
mg/kg intraperitoneal-mammal LDLO; 2459 mg/kg intraperitoneal-rat LD50; 1548
mg/kg intraperitoneal-mouse LD50; 2000 mg/kg intraperitoneal-guinea pig LDLO;
reproductive effects data (RT ECS).
CARC NOG ST AT US: Human inadequate evidence, animal inadequate evidence (I ARC
I EN
Group-3).
LOC EFFEC S:
AL T I rritant - I nhalation, skin, eye.
AC E T OXI C T Y LEVEL:
UT I Moderately toxic by inhalation, ingestion.
T ARG EFFEC S:
ET T Central nervous system depressant. Poisoning may also affect the
nervous system, liver and kidneys.
AT I NCREASED RI SK FROM EXPOSURE: Pregnant women
Catalog # 23400 4
Xylene
ADDI T I ONAL DAT A: Alcohol may enhance the toxic effects. Stimulants such as
epinephrine or ephedrine may induce ventricular fibrillation.
HEAL T H EFFECT S AND FI R S T AI D
I NHALAT I ON: I rritant/Narcotic
1000 ppm immediately dangerous to life or health.
AC E EXPOSURE:
UT
I rritation of the upper respiratory tract may occur at 200 ppm. Exposure to higher
concentrations may cause more severe irritation and initial central nervous system
excitation followed by depression. Signs and symptoms may include respiratory difficulty
and substernal pain, transient euphoria and emotional lability, headache, nausea,
vomiting, anorexia, abdominal pain, dizziness, drowsiness, ataxia, and staggering.
T here may be salivation, slurred speech, blurred vision, nystagmus, tinnitus, tremors,
confusion, and flushing of the face and a feeling of increased body heat. I n severe
exposures, there may be stupor, anesthesia, unconsciousness, and coma which may be
punctuated by episodes of neuroirritability, but rarely frank convulsions, except
in terminal asphyxia. Liver and kidney damage may occur, but are usually mild and
transient. A group of subjects who inhaled 12.3 umol/l of xylene while exercising
became significantly impaired on 3 neuropsychological tests. Exposure of 3 painters to
approximately 10,000 ppm for 18.5 hours resulted in 1 death from pulmonary edema
and petechial brain hemorrhage. Both survivors were unconsciousness for 19-24 hours
and experienced retrograde amnesia, hypothermia, and lung congestion. Renal and
hepatic impairment also developed. C omplete recovery took 15 days. High
concentrations may cause death from sudden ventricular fibrillation, but more frequently
death occurs from respiratory arrest.
CHRONI C EXPOSURE:
Repeated or prolonged inhalation of vapors above 200 ppm may cause nausea,
vomiting, abdominal pain, and anorexia. Other common complaints include headache,
fatigue, lassitude, irritability, breathing difficulties, and flatulence. Effects on the
nervous system may result in excitation, followed by depression, paresthesias, tremors,
apprehension, impaired memory, insomnia, vertigo, and tinnitus. Effects on reaction
time, manual coordination, body balance and EEG occurred with repeated exposure to
90 ppm of M-Xylene. Sweetish taste in the mouth, dry nose and throat, strong thirst,
mucosal hemorrhage, and anemia have been reported. Effects on the liver, kidney,
cardiovascular system, and the bone marrow have been reported, although the latter
has been questioned. Exposure of rabbits to 1150 ppm for 40-55 days resulted in a
reversible decrease in the red and white cell counts and an increase in the platelets.
One case of an apparent epileptiform seizure following a relatively brief exposure has
occurred.
Women may develop menstrual disorders, such as menorrhagia or metrorrhagia,
infertility, and pathological pregnancy conditions including toxicosis, danger of
miscarriage, and hemorrhaging during delivery. Repeated exposure of pregnant mice,
rats and rabbits to the individual or the mixed isomers has resulted in maternal effects
Catalog # 23400 5
Xylene
and effects on fertility, on the embryo or fetus, and specific developmental
abnormalities. I ncluded among these effects are fetal death, fetotoxicity, pre-and post-
implantation mortality, abortion, craniofacial and musculoskeletal abnormalities, and
extra embryonic structures.
FI RST AI D:
Remove from exposure area to fresh air immediately. I f breathing has stopped,
perform artificial respiration. Keep person warm and at rest. T reat symptomatically and
supportively. G medical attention immediately.
et
SKI N CONT AC :
T I rritant
AC E EXPOSURE:
UT
Liquid xylene is a defatting agent and may cause a burning sensation, drying,
vasodilation, erythema, and possibly blistering. T he liquid is readily absorbed through
intact or broken skin at a rate of approximately 4-10 mg/cm2/hour, but systemic effects
have not been reported.
CHRONI C EXPOSURE:
Repeated or prolonged contact may cause defatting of the skin with drying, erythema,
cracking, thickening and blistering. Repeated application of 95% xylene to rabbit skin
caused moderate to marked irritation from erythema and moderate necrosis. One
case of allergic contact urticaria has been reported.
FI RST AI D:
Remove contaminated clothing and shoes immediately. Wash affected area with soap
or mild detergent and large amounts of water until no evidence of chemical remains
(approximately 15-20 minutes). G medical attention immediately.
et
EYE CONT AC :
T I rritant
AC E EXPOSURE:
UT
200 ppm has caused conjunctival irritation in humans; at higher concentrations,
irritation may be severe. Vapor exposure has also caused tearing and photophobia. An
accidental splash in the human eye caused transient superficial damage with rapid
recovery, although reversible corneal burns have also been reported.
CHRONI C EXPOSURE:
Repeated or prolonged exposure to high vapor concentrations may cause a burning
sensation, conjunctivitis and blurred vision; reversible vascular, epithelial keratopathy
has been reported in some workers.
Catalog # 23400 6
Xylene
FI RST AI D:
Wash eyes immediately with large amounts of water or normal saline occasionally lifting
upper and lower lids, until no evidence of chemical remains (approximately 15-20
minutes). G medical attention immediately.
et
I NG I ON:
EST Narcotic
AC E EXPOSURE:
UT
May cause a burning sensation in the mouth and stomach, salivation, severe
gastrointestinal distress with nausea and vomiting, possibly hematemesis, and toxic
effects including signs of central nervous system depression and other symptoms as in
acute inhalation, including ventricular fibrillation and liver and kidney injury. I ngestion
of small quantities of 90% xylene plus toluene produced urinary dextrose and
urobilinogen excretion with toxic hepatitis, which was reversible in 20 days. A dose of
15-30 milliliters (about 1/2-1 ounce) is the expected human lethal dose. With aspiration
or even a few milliliters into the lungs, severe coughing, distress, chemical pneumonitis,
rapidly developing pulmonary edema, and hemorrhage may occur.
CHRONI C EXPOSURE:
No data available on the ortho-isomer. Repeated ingestion of the mixed, meta-, or
para-isomers by pregnant mice resulted in effects on fertility, on the embryo or fetus, or
specific developmental abnormalities. I ncluded among these effects were fetotoxicity,
litter size, craniofacial and musculoskeletal system abnormalities, and post-implantation
mortality.
FI RST AI D:
Extreme care must be used to prevent aspiration. G astric lavage with a cuffed
endotracheal tube in place to prevent further aspiration should be done within 15
minutes. I n the absence of depression or convulsions or impaired gag reflex, emesis
can also be induced using syrup or I pecac without increasing the hazard of aspiration
(Dreisbach, Handbook of Poisoning, 12th Ed.). T reat symptomatically and supportively.
Gastric lavage should be performed by qualified medical personnel. G medical
et
attention immediately.
ANT I DOT E: No specific antidote. T reat symptomatically and supportively.
R EACT I VI T Y
REAC I VI T Y:
T Stable under normal temperatures and pressures.
I NCOMPAT I BI LI T I ES:
NI T RI C AC D:
I Exothermic reaction.
OXI DI ZERS (ST RONG): Fire and explosion hazard.
Catalog # 23400 7
Xylene
PLAST I C RUBBER, C
S, OAT I NG S: May be attacked.
SULFURI C AC D:
I Exothermic reaction.
DEC OMPOSI T I ON: T hermal decomposition products may include toxic oxides of
carbon.
POLYMERI ZAT I ON: Hazardous polymerization has not been reported to occur under
normal temperatures and pressures.
S T OR AGE AND DI S POS AL
Observe all Federal, State and local regulations when storing or disposing of this
substance. For assistance, contact the district director of the Environmental Protection
Agency.
ST ORAGE: Store in accordance with 29 C 1910.106.
FR
BONDI NG AND GROUNDI NG:
Substances with low electroconductivity, which may be ignited by electrostatic sparks,
should be stored in containers which meet the bonding and grounding guidelines
specified in NFPA 77-1983, Recommended Practice on Static Electricity. Protect against
physical damage. Outside or detached storage is preferable. I nside storage should be
in a standard flammable liquids storage room or cabinet. Separate from oxidizing
materials (NFPA 49, Hazardous C hemicals Data, 1975). Store away from incompatible
sustenances.
DI SPOSAL:
Disposal must be in accordance with standards applicable to generators of hazardous
waste, 40C 262. EPA Hazardous Waste Number U239.
FR
CONDI T I ONS T O AVOI D
Avoid contact with heat, sparks, flames, or other sources of ignition. Vapors may be
explosive. Avoid overheating of containers; containers may violently rupture in heat of
fire. Avoid contamination of water sources.
S PI L L AND L EAK PR OCEDUR ES
SOI L SPI LL:
Dig a holding area such as a pit, pond or lagoon to contain spill and dike surface flow
using barrier of soil, sandbags, foamed polyurethane or foamed concrete. Absorb liquid
mass with fly ash or cement powder. I mmobilize spill with universal gelling agent.
Reduce vapor and fire hazard with appropriate foam.
Catalog # 23400 8
Xylene
AI R SPI LL: Knock down vapors with water spray. Keep upwind.
WAT ER SPI LL:
Limit spill motion and dispersion with natural barriers or oil spill control booms. Apply
detergents, soaps, alcohols or another surface active agent. Apply universal gelling
agent to immobilize trapped spill and increase efficiency of removal. I f dissolved, at a
concentration of 10 ppm or greater, apply activated carbon at ten times the amount that
has been spilled. Use suction hoses to remove trapped spill material. Use mechanical
dredges or lifts to extract immobilized masses of pollution and precipitates.
OC UPAT I ONAL SPI LL:
C
Shut off ignition sources. Stop leak if you can do it without risk. Use water spray to
reduce vapors. For small spills, take up with sand or other absorbent material and place
into containers for later disposal. For larger spills, dike far ahead of spill for later
disposal. No smoking, flames or flares in hazard area. Keep unnecessary people away;
isolate hazard area and restrict entry.
REPORT ABLE QUANT I T Y (RQ): 1000 pounds
T he Superfund Amendments and Reauthorization Act (SARA) Section 304 requires hat a
release equal to or greater than the reportable quantity for this substance be
immediately reported to the local emergency planning committee and the state
emergency response commission (40 C 355.40). I f the release of this substance is
FR
reportable under C ERC Section 103, the National Response C
LA enter must be notified
immediately at (800) 424-8802 or (202) 426-2675 in the metropolitan Washington, D.C .
area (40 C 302.6).
FR
PR OT ECT I VE EQUI PMENT
VENT I LAT I ON:
Provide local exhaust or general dilution ventilation to meet published exposure limits.
Ventilation equipment must be explosion-proof.
RESPI RAT OR:
T he following respirators and maximum use concentrations are recommendations by the
U.S. Department of Health and Human Services, NI OSH Pocket G uide to C hemical
Hazards; NI OSH C riteria Documents or by the U.S. Department of Labor, 29 C 1910
FR
Subpart Z.
T he specific respirator selected must be based on contamination levels found in the
work place, must not exceed the working limits of the respirator and be jointly approved
by the National I nstitute for Occupational Safety and Health and the Mine Safety and
Health Administration (NI OSH-MSHA).
Catalog # 23400 9
Xylene
1000 ppm:
Any chemical cartridge respirator with organic vapor cartridge(s). Any powered air-
purifying respirator with organic vapor cartridge(s). Any supplied-air respirator.
Any self-contained breathing apparatus.
ESC APE: Any air-purifying full facepiece respirator (gas mask) with a chin-style or front-
or back-mounted organic vapor canister. Any appropriate escape-type self-contained
breathing apparatus.
FOR FI RE FI G I NG AND OT HER I MMEDI AT ELY T O LI FE OR DANG
HT EROUS T O
LI FE OR HEALT H CONDI T I ONS:
Self-contained breathing apparatus with full facepiece operated in pressure-demand or
other positive pressure mode. Supplied-air respirator with full facepiece and operated in
pressure-demand or other positive pressure mode in combination with an auxiliary self-
contained breathing apparatus operated in pressure-demand or other positive pressure
mode.
CLOT HI NG Employee must wear appropriate protective (impervious) clothing and
:
equipment to prevent repeated or prolonged skin contact with this substance.
G LOVES: Employee must wear appropriate protective gloves to prevent contact with
this substance.
EYE PROT EC I ON: Employee must wear splash-proof or dust-resistant safety goggles to
T
prevent eye contact with this substance.
EMERG ENC EYE WASH: Where there is any possibility that an employee's eyes may be
Y
exposed to this substance, the employer should provide an eye wash fountain within the
immediate work area for emergency use.
Catalog # 23400 10
Xylene
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