MATERIAL SAFETY DATA SHEET
EMERGENCY TELEPHONE 800-424-9300 (Chemtrec) Health : 2
Lonza Inc.90 Boroline Road Allendale NJ 07401 Flammability : 1
800-777-1875 (9am - 5pm) 309-697-7200 (After 5pm)
Reactivity : 0
98616 Dantoserve SG PAGE 1 OF 7
************************************************************************************
MATERIAL DATE ISSUED DOT HAZARD CLASSIFICATION
Dantoserve SG 11/02/04 鈥? REVISION Non-hazardous
DOT SHIPPING NAME
Mixture Not regulated
CAS NO. SUPERCEDES
04/22/02 DOT LABEL None
Mixture
FORMULA
CHEMICAL NAME (actives): 1,3-Dihydroxymethyl-5,5-dimethylhydantoin; 1,3-Dimethylol-5,5-
dimethylhydantoin; 1,3-Bis(hydroxymethyl)-5,5-dimethyl2,4-
imidazolidinedione and Benzisothiazolinone; 1,2-Benzisothiazolin-3-one
SYNONYMS (actives): DMDM Hydantoin and Benzisothiazolinone
********************************* I - INGREDIENTS ***********************************
APPROXIMATE
WEIGHT% TWA/TLV
1,3-Dihydroxymethyl-5,5-dimethylhydantoin * None established
(CAS No. 6440-58-0)
1-Hydroxymethyl-5,5-dimethylhydantoin * None established
(CAS No. 116-25-6)
3-Hydroxymethyl-5,5-dimethylhydantoin * None established
(CAS No. 16228-00-5)
5,5-Dimethylhydantoin (CAS No. 77-71-4) * None established
Benzisothiazolinone 1 None established
(CAS No. 2634-33-5)
Water (CAS No. 7732-18-5) 37 None established
The sum of the four asterisked components is approximately 62%. These four
components, along with Formaldehyde, are present as an equilibrium mixture. The
total available Formaldehyde moiety in this product is 15%, of which up to 0.09%
is present as free Formaldehyde in solution.
*********************** II - PHYSICAL AND CHEMICAL PROPERTIES ***********************
APPEARANCE Light brownish liquid pH Not known
VISCOSITY Not known ODOR Slight Formaldehyde
BOILING POINT Not known MELTING OR FREEZING POINT Not known
VAPOR DENSITY (Air=1) Not known VAPOR PRESSURE (mm Hg) Not known
PERCENT VOLATILE (by weight) 37% SPECIFIC GRAVITY (WATER = 1)~1.15 @ 25掳C
EVAPORATION RATE (Butyl Acetate=1) <1 SOLUBILITY IN WATER Soluble
The information provided herein is compiled form internal reports and data form professional publications. IT IS FURNISHED WITHOUT WARRANTY OF
ANY KIND, EXPRESSED OR IMPLIED. It is intended to assist in evaluating the suitability and proper use of the material in manufacturing and in the
development and implementation of safety precautions and procedures.
MATERIAL SAFETY DATA SHEET
EMERGENCY TELEPHONE 800-424-9300 (Chemtrec)
Lonza Inc. 90 Boroline Road Allendale NJ 07401 800-777-1875 (9am - 5pm) 309-697-7200 (After 5pm)
98616 Dantoserve SG PAGE 2 OF 7
*********************** III - FIRE AND EXPLOSION INFORMATION ***********************
FLASH POINT >200oF AUTO IGNITION TEMPERATURE Not known
LOWER EXPLOSION LIMIT (%) Not applicable UPPER EXPLOSION LIMIT (%) Not applicable
EXTINGUISHING MEDIA FOAM X CO2 X
ALCOHOL FOAM
DRY CHEMICAL X WATER X OTHER
SPECIAL FIRE FIGHTING PROCEDURES:
Must wear NIOSH approved self-contained breathing apparatus and protective clothing.
Cool fire-exposed containers with water spray.
UNUSUAL FIRE AND EXPLOSION HAZARDS:
Products of combustion are toxic. Heating of this product in the open will release
Formaldehyde. When this product is spread over a large area, irritating levels of
gaseous formaldehyde may be produced.
************************ IV - HEALTH EFFECTS INFORMATION ****************************
PRIMARY ROUTES OF ENTRY - SKIN CONTACT X EYE CONTACT X
X
INHALATION INGESTION
EFFECTS OF OVEREXPOSURE
Based upon information available for this material, and closely related materials, it
is anticipated that direct contact will produce mild eye and skin irritation and
moderate eye irritation, and inhalation may produce mild, reversible irritation to the
mucous membranes. Components of this material have been shown to exhibit weak
sensitization potential in both animal and human overexposure.
Heating this material in an open vessel will result in the release of Formaldehyde.
Formaldehyde has been shown to cause sensitization reactions in some sensitive
individuals. Therefore, repeated contact should be avoided. Formaldehyde is listed
by IARC, OSHA and NTP as a possible human carcinogen by inhalation.
OVEREXPOSURE MAY AGGRAVATE EXISTING CONDITIONS:
May cause allergic response in persons with pre-existing sensitivity.
EMERGENCY AND FIRST AID PROCEDURES:
Eyes: Flush eyes with large amounts of running water for at least 15 minutes. Hold
eyelids apart to ensure rinsing of the entire surface of the eye and lids with water.
Get immediate medical attention.
Skin: Wash affected areas with plenty of running water, and soap if available, for
several minutes. Remove contaminated clothing and shoes. Seek medical attention if
irritation develops.
Ingestion: If swallowed, give 3-4 glasses of water but DO NOT induce vomiting. If
vomiting does occur, give fluids again. Get medical attention to determine whether
vomiting or evacuation of stomach is necessary. Do not give anything by mouth to an
unconscious or convulsing person.
The information provided herein is compiled from internal reports and data from professional publications. IT IS FURNISHED WITHOUT WARRANTY OF
ANY KIND, EXPRESSED OR IMPLIED. It is intended to assist in evaluating the suitability and proper use of the material in manufacturing and in the
development and implementation of safety precautions and procedures.
MATERIAL SAFETY DATA SHEET
EMERGENCY TELEPHONE 800-424-9300 (Chemtrec)
Lonza Inc. 90 Boroline Road Allendale NJ 07401 800-777-1875 (9am - 5pm) 309-697-7200 (After 5pm)
98616 Dantoserve SG PAGE 3 OF 7
************************ IV - HEALTH EFFECTS INFORMATION (continued) ****************
EMERGENCY AND FIRST AID PROCEDURES (continued):
Inhalation: Remove from area to fresh air. If not breathing, clear airway and start
artificial respiration. If victim is having trouble breathing, give supplemental
oxygen. Get immediate medical attention.
CHEMICALS LISTED AS CARCINOGEN BY:
NATIONAL TOXICOLOGY PROGRAM 鈥? No*
- No*
I.A.R.C. MONOGRAPHS
- No*
OSHA
*Note: Heating this material in an open vessel will release Formaldehyde. Formaldehyde
is listed by IARC, OSHA and NTP as a possible human carcinogen by inhalation.
*************************** V - REACTIVITY INFORMATION ******************************
X
STABILITY: STABLE CONDITIONS TO AVOID
o
Temperatures above 90 C (to avoid decomposition with
UNSTABLE
release of Formaldehyde). Heating in an open vessel
(which will release Formaldehyde).
HAZARDOUS DECOMPOSITION PRODUCTS
Thermal decomposition may produce toxic vapors/fumes of Formaldehyde, other organic
compounds and oxides of carbon and nitrogen.
HAZARDOUS POLYMERIZATION CONDITIONS TO AVOID
WILL NOT X None known
MAY
OCCUR OCCUR
INCOMPATIBILITY (MATERIALS TO AVOID)
OTHER X Strong acids and alkalis (stable between pH 4 and 9)
WATER
*********************** VI - SPILL AND DISPOSAL INFORMATION *************************
STEPS TO BE TAKEN IN CASE OF MATERIAL SPILL OR RELEASE
CAUTION! Wear appropriate protective equipment and NIOSH approved respirator where
mists or vapors of unknown concentrations may be generated (self-contained breathing
apparatus preferred). WARNING! When spilled, and liquid spreads over a large area,
irritating levels of gaseous Formaldehyde may be produced.
Dike and contain spill with inert material (sand, earth, etc.). Transfer the liquid
and solid separately to containers for recovery or disposal. Keep spill out of sewers
and open bodies of water.
WASTE DISPOSAL METHOD
Dispose of in compliance with all Federal, state and local laws and regulations.
Incineration is the preferred method.
The information provided herein is compiled from internal reports and data from professional publications. IT IS FURNISHED WITHOUT WARRANTY OF
ANY KIND, EXPRESSED OR IMPLIED. It is intended to assist in evaluating the suitability and proper use of the material in manufacturing and in the
development and implementation of safety precautions and procedures.
MATERIAL SAFETY DATA SHEET
EMERGENCY TELEPHONE 800-424-9300 (Chemtrec)
Lonza Inc. 90 Boroline Road Allendale NJ 07401 800-777-1875 (9am - 5pm) 309-697-7200 (After 5pm)
98616 Dantoserve SG PAGE 4 OF 7
*********************** VII - PERSONAL PROTECTION INFORMATION ***********************
ENGINEERING CONTROLS
In processes where mists or vapors may be generated, proper ventilation must be
provided in accordance with good ventilation practices.
RESPIRATORY PROTECTION
In processes where mists or vapors may be generated, a NIOSH approved respirator is
advised in the absence of proper environmental controls.
PROTECTIVE GLOVES
Rubber or neoprene, when needed, to prevent skin contact.
EYE PROTECTION
Wear chemical splash goggles where there is a potential for eye contact. Use safety
glasses with side shields under typical use conditions where eye contact is not a
concern.
OTHER PROTECTIVE EQUIPMENT
Eye wash; safety shower; protective clothing (long sleeves, coveralls or other, as
appropriate), when needed, to prevent skin contact.
*************************** VIII - STORAGE AND HANDLING ****************************
PRECAUTIONS FOR STORAGE AND HANDLING:
Store at or near room temperature. Keep containers tightly closed until used. Do
o
not store below 60 F, to avoid formation of crystals in this material. Preparation of
formulations with this material should be carried out in closed vessels. While
o
formulating under these conditions, temperatures as high as 80 C can be tolerated for
a short period of time.
****************** IX - TOXICOLOGY AND ECOTOXICOLOGY INFORMATION *******************
TOXICITY
No toxicity information available for this specific material. The toxicology
information provided below is for a related material(s) and/or component(s) of this
specific material.
ACUTE
For Dantogard 2000(a 70% solution of DMDM Hydantoin, Hydroxymethylhydantoin and
Dimethylhydantoin, which contains up to 0.09% free Formaldehyde in solution.)
- oral LD50 (rat): 2890 mg/kg
- dermal LD50 (rabbit): >2000 mg/kg
- inhalation LC50 (rat 鈥? 4-hour): > 2 mg/l
- eye irritation (rabbit): Mild to moderate irritation that cleared by day 4, post
dose.
- skin irritation (rabbit): Moderate irritation that cleared by day 7, post dose.
- skin sensitization (guinea pig - Buehler test): Not a sensitizer.
The information provided herein is compiled from internal reports and data from professional publications. IT IS FURNISHED WITHOUT WARRANTY OF
ANY KIND, EXPRESSED OR IMPLIED. It is intended to assist in evaluating the suitability and proper use of the material in manufacturing and in the
development and implementation of safety precautions and procedures.
MATERIAL SAFETY DATA SHEET
EMERGENCY TELEPHONE 800-424-9300 (Chemtrec)
Lonza Inc. 90 Boroline Road Allendale NJ 07401 800-777-1875 (9am - 5pm) 309-697-7200 (After 5pm)
98616 Dantoserve SG PAGE 5 OF 7
************* IX - TOXICOLOGY AND ECOTOXICOLOGY INFORMATION (continued)**************
TOXICITY (continued):
ACUTE (continued)
For Benzisothiazolinone:
- oral LD50 (rat): 1020 mg/kg
- eye irritation (rabbit): Severe irritant to corrosive.
- skin sensitization (guinea pig - Buehler test): Sensitizer
- skin sensitization (human 鈥? patch test): Weak sensitizer.
GENOTOXICITY/MUTAGENICITY
For Glydant XL-1000 (a solid mixture of DMDM Hydantoin and Hydroxymethylhydantoin,
which contains up to 0.09% free Formaldehyde):
- Ames test (Four strains Salmonella typhimurium and Escherichia coli): Not mutagenic
with or without metabolic activation.
REPRODUCTIVE/DEVELOPMENTAL
For Glydant (a 53% solution of DMDM Hydantoin, Hydroxymethylhydantoin and
Dimethylhydantoin, which contains up to 2% free Formaldehyde in solution):
- developmental toxicity (rabbit - oral): No evidence of developmental toxicity
effects was observed at an exposure dose of 750 mg/kg/day administered from day 6
through 18 of gestation.
- developmental toxocity (rabbit - dermal): No evidence of developmental toxicity
effects was observed at an exposure dose of 1000 mg/kg/day administered from day 7
through 18 of gestation.
SUBCHRONIC
For Glydant:
- oral toxicity (rat 鈥? 90 days): No systemic toxicity or target organ effects were
observed at a dose regimen of 400 mg/kg/day for eight weeks, followed by a dose
regimen of 600 mg/kg/day for an additional five weeks.
- dermal toxicity (rabbit - 90 days): No systemic toxicity or target organ effects
were observed at dosage levels of approximately 1000 mg/kg/day.
ECOTOXICITY
AQUATIC
For Benzisothiazolinone:
- LC50 (fish 鈥? 96-hour): 5-50 mg/l
- EC50 (Algae 鈥? 72-hour): 0.37 mg/l
******************* X - MISCELLANEOUS AND REGULATORY INFORMATION ********************
FEDERAL LEVEL REGULATIONS:
Toxic Substances Control Act (TSCA Inventory) Status:
This product is currently listed on the EPA TSCA 8(b) inventory list.
TSCA Section 12(b) Export Notification:
Components present in this product which, if exported, could require either annual
or one-time reporting under this regulation are as follows:
Typical Maximum
Chemical Name CAS Number Concentration
None known
The information provided herein is compiled from internal reports and data from professional publications. IT IS FURNISHED WITHOUT WARRANTY OF
ANY KIND, EXPRESSED OR IMPLIED. It is intended to assist in evaluating the suitability and proper use of the material in manufacturing and in the
development and implementation of safety precautions and procedures.
MATERIAL SAFETY DATA SHEET
EMERGENCY TELEPHONE 800-424-9300 (Chemtrec)
Lonza Inc. 90 Boroline Road Allendale NJ 07401 800-777-1875 (9am - 5pm) 309-697-7200 (After 5pm)
98616 Dantoserve SG PAGE 6 OF 7
******************* X - MISCELLANEOUS AND REGULATORY INFORMATION (continued)**********
FEDERAL LEVEL REGULATIONS (continued):
OSHA Hazard Communication Standard:
Under certain conditions, this material will release Formaldehyde. Occupational
exposures to Formaldehyde above specified threshold levels are regulated by the
Hazard Communication Standard for Formaldehyde in the Code of Federal Regulations
(29 CFR 1910.1048).
EPA REGULATION ON PESTICIDES
This product is an EPA FIFRA registered pesticide, which can only be used
commercially in the EPA FIFRA registered application(s) noted on the product label.
EPA Registration No. 6836-306
CERCLA (Comprehensive Environmental Response, Compensation and Liability Act of
1980 requires notification of the National Response Center
(Telephone 800-424-8802) in the event of a release of quantities of the
following hazardous materials contained in this product, if the release is
equal to or greater than the Reportable Quantities (RQs) listed in
40 CFR 302.4:
Typical Maximum
Chemical Name CAS Number Concentration
None known
SARA Title III, Sections 302/304 (Superfund Amendments and Reauthorization act of
1986) - This act requires emergency planning, including agency notification, for
possible release of the following components of this material, based upon the
Threshold Planning Quantities (TPQs) and release Reportable Quantities (RQs)
listed for the Components in 40 CFR 355:
Typical Maximum
Chemical Name CAS Number Concentration
None known
SARA Title III Sections 311/312 - This act requires reporting under the Community
Right-to-Know provisions due to the inclusion of the following components of this
material in one or more of the five hazard categories listed in 40 CFR 370:
Hazard *)
Chemical Name CAS Number Categories
Benzisothiazolinone 2634-33-5 A
*) The five hazard categories are as follows: F=FIRE HAZARD; S= SUDDEN RELEASE OF
PRESSURE; R=REACTIVE; A=IMMEDIATE (ACUTE) HEALTH HAZARD; C=DELAYED (CHRONIC)
HEALTH HAZARD
SARA Title III Section 313 - This act requires submission of annual reports of the
releases of the following components of this material if the threshold reporting
quantities, as listed in 40 CFR 372, are met or exceeded:
Typical Maximum
Chemical Name CAS Number Concentration
None known
The information provided herein is compiled from internal reports and data from professional publications. IT IS FURNISHED WITHOUT WARRANTY OF
ANY KIND, EXPRESSED OR IMPLIED. It is intended to assist in evaluating the suitability and proper use of the material in manufacturing and in the
development and implementation of safety precautions and procedures.
MATERIAL SAFETY DATA SHEET
EMERGENCY TELEPHONE 800-424-9300 (Chemtrec)
Lonza Inc. 90 Boroline Road Allendale NJ 07401 800-777-1875 (9am - 5pm) 309-697-7200 (After 5pm)
98616 Dantoserve SG PAGE 7 OF 7
******************* X - MISCELLANEOUS AND REGULATORY INFORMATION (continued) ********
FEDERAL LEVEL REGULATIONS (continued):
STATE RIGHT-TO-KNOW REGULATIONS:
CALIFORNIA PROPOSITION 65 - Components present in this material which the State of
California has found to cause cancer, birth defects or other reproductive harm
are as follows:
AS A CANCER HAZARD: Typical Maximum
Chemical Name CAS Number Concentration
Formaldehyde (gas) 50-00-0 Trace
MASSACHUSETTS Right-to-Know - The following components of this material are included
in the Massachusetts Substance List and are present at or above reportable
levels:
Typical Maximum
Chemical Name CAS Number Concentration
Formaldehyde 50-00-0 900 ppm
MICHIGAN Critical Materials - The following components of this material are included
in the Michigan Critical Materials List:
Typical Maximum
Chemical Name CAS Number Concentration
None known
NEW JERSEY Right-to-Know - The following components of this material are included in
the New Jersey Hazardous Substance List and are present at or above reportable
levels:
Typical Maximum
Chemical Name CAS Number Concentration
Benzisothiazolinone 2634-33-5 1
PENNSYLVANIA Right-to-Know - The following components of this material are included
in the Pennsylvania Hazardous Substance List and are present at or above
reportable levels:
Typical Maximum
Chemical Name CAS Number Concentration
Formaldehyde 50-00-0 900 ppm
The information provided herein is compiled from internal reports and data from professional publications. IT IS FURNISHED WITHOUT WARRANTY OF
ANY KIND, EXPRESSED OR IMPLIED. It is intended to assist in evaluating the suitability and proper use of the material in manufacturing and in the
development and implementation of safety precautions and procedures.
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