PRODUCT #: N0133 NAME: N-NITROSO DIBUTYLAMINE ISOPAC
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 4:00PM
Sigma Chemical Co. Aldrich Chemical Co., Inc. Fluka Chemical Corp.
P.O. Box 14508 1001 West St. Paul 1001 West St. Paul
St. Louis, MO 63178 Milwaukee, WI 53233 Milwaukee, WI 53233
Phone: 314-771-5765 Phone: 414-273-3850 Phone: 414-273-3850
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: N0133
NAME: N-NITROSO DIBUTYLAMINE ISOPAC
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 924-16-3
MF: C8H18N2O
EC NO: 213-101-1
SYNONYMS
BUTYLAMINE, N-NITROSODI- * N-BUTYL-N-NITROSO-1-BUTAMINE * DBN * DBNA *
DIBUTYLAMINE, N-NITROSO- (6CI) * DI-N-BUTYLNITROSAMIN (GERMAN) *
DIBUTYLNITROSAMINE * DI-N-BUTYLNITROSAMINE * N,N-DI-N-
BUTYLNITROSAMINE * N,N-DIBUTYLNITROSOAMINE * NDBA *
NITROSODIBUTYLAMINE * N-NITROSODIBUTYLAMINE * N-NITROSO-DI-N-
BUTYLAMINE * RCRA WASTE NUMBER U172 *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
TOXIC
MAY CAUSE CANCER.
MAY CAUSE HERITABLE GENETIC DAMAGE.
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
DO NOT BREATHE VAPOR.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND
SHOES. CALL A PHYSICIAN.
IF INHALED, REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT,
CALL A PHYSICIAN.
IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING
THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
ABSORB ON SAND OR VERMICULITE AND PLACE IN CLOSED CONTAINERS FOR
DISPOSAL.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
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PRODUCT #: N0133 NAME: N-NITROSO DIBUTYLAMINE ISOPAC
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 4:00PM
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
HANDLE IN A CLOSED SYSTEM.
SELF-CONTAINED BREATHING APPARATUS SHOULD BE WORN.
COMPATIBLE CHEMICAL-RESISTANT GLOVES.
CHEMICAL SAFETY GOGGLES.
PROTECT FROM MOISTURE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
YELLOW OIL.
PHYSICAL PROPERTIES
BOILING POINT: 84-85 DEG C @ 3-4MM
SOLUBILITY:
WATER -SLIGHTLY SOLUBLE ETHANOL -SOLUBLE
ETHER -SOLUBLE
BENZENE -SOLUBLE
SPECIFIC GRAVITY: 0.899
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
STABILITY
STABLE.
CONDITIONS TO AVOID
MOISTURE
INCOMPATIBILITIES
AVOID CONTACT WITH COPPER SALTS, MERCURY SALTS AND STRONG ACIDS.
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
HAZARDOUS POLYMERIZATION
WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN.
MAY CAUSE IRRITATION.
CHRONIC EFFECTS
CARCINOGEN.
MUTAGEN.
NITROSAMINES ARE SUSPECTED OF CAUSING CANCERS OF THE LUNG, NASAL
SINUSES, BRAIN, ESOPHAGUS, STOMACH, LIVER, BLADDER AND KIDNEY.
RTECS #: EJ4025000
1-BUTANAMINE, N-BUTYL-N-NITROSO-
TOXICITY DATA
ORL-RAT LD50:1200 MG/KG NATWAY 50,735,1963
SCU-RAT LD50:1200 MG/KG XENOBH 3,271,1973
ORL-HAM LD50:2150 MG/KG ZKKOBW 79,85,1973
IPR-HAM LD50:1200 MG/KG ZKKOBW 79,85,1973
SCU-HAM LD50:561 MG/KG PSEBAA 136,168,1971
TARGET ORGAN DATA
CARDIAC (CARDIOMYOPATHY INCLUDING INFARCTION)
LUNGS, THORAX OR RESPIRATION (TUMORS)
LUNGS, THORAX OR RESPIRATION (BRONCHOGENIC CARCINOMA)
GASTROINTESTINAL (TUMORS)
LIVER (OTHER CHANGES)
LIVER (TUMORS)
KIDNEY, URETER, BLADDER (CHANGES PRIMARILY IN GLOMERULI)
KIDNEY, URETER, BLADDER (CHANGES IN TUBULES)
KIDNEY, URETER, BLADDER (BLADDER TUMORS)
ENDOCRINE (OTHER CHANGES)
BLOOD (LEUKEMIA)
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PRODUCT #: N0133 NAME: N-NITROSO DIBUTYLAMINE ISOPAC
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 4:00PM
SKIN AND APPENDAGES (TUMORS)
EFFECTS ON EMBRYO OR FETUS (FETOTOXICITY)
EFFECTS ON EMBRYO OR FETUS (FETAL DEATH)
TUMORIGENIC EFFECTS (TRANSPLACENTAL TUMORIGENESIS)
EFFECTS ON NEWBORN (WEANING OR LACTATION INDEX)
TUMORIGENIC (CARCINOGENIC BY RTECS CRITERIA)
TUMORIGENIC (NEOPLASTIC BY RTECS CRITERIA)
TUMORIGENIC (EQUIVOCAL TUMORIGENIC AGENT BY RTECS CRITERIA)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
TOXIC
R 45
MAY CAUSE CANCER.
R 46
MAY CAUSE HERITABLE GENETIC DAMAGE.
R 20/21/22
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
S 45
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
S 36/37/39
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
S 23
DO NOT BREATHE VAPOR.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
IARC CANCER REVIEW:ANIMAL SUFFICIENT EVIDENCE IMEMDT 17,51,1978
IARC CANCER REVIEW:ANIMAL SUFFICIENT EVIDENCE IMEMDT 28,151,1982
IARC CANCER REVIEW:HUMAN NO ADEQUATE DATA IMEMDT 17,51,1978
IARC CANCER REVIEW:GROUP 2B IMSUDL 7,56,1987
OEL-FRANCE;CARCINOGEN JAN 1993
OEL-GERMANY;CARCINOGEN JAN 1993
OEL-SWITZERLAND;CARCINOGEN JAN 1993
EPA GENETOX PROGRAM 1988, POSITIVE: CARCINOGENICITY-MOUSE/RAT;
HISTIDINE REVERSION-AMES TEST
EPA GENETOX PROGRAM 1988, POSITIVE: V79 CELL CULTURE-GENE MUTATION
EPA GENETOX PROGRAM 1988, NEGATIVE: IN VITRO CYTOGENETICS-NONHUMAN;
SPERM MORPHOLOGY-MOUSE
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: MAMMALIAN MICRONUCLEUS; IN
VITRO SCE-NONHUMAN
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: IN VITRO UDS-HUMAN FIBROBLAST
EPA GENETOX PROGRAM 1988, POSITIVE: CHO GENE MUTATION
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
ON EPA IRIS DATABASE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, APRIL 1997
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PRODUCT #: N0133 NAME: N-NITROSO DIBUTYLAMINE ISOPAC
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 4:00PM
NIOSH ANALYTICAL METHOD, 1994: NITROSAMINES, 2522
NTP 7TH ANNUAL REPORT ON CARCINOGENS, 1992 : ANTICIPATED TO BE
CARCINOGEN
OSHA ANALYTICAL METHOD #27
U.S. INFORMATION
THIS PRODUCT IS SUBJECT TO SARA SECTION 313 REPORTING REQUIREMENTS.
CALIFORNIA PROPOSITION 65:
THIS PRODUCT IS OR CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF
CALIFORNIA TO CAUSE CANCER.
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 1997 SIGMA CHEMICAL CO., ALDRICH CHEMICAL CO., INC.,
FLUKA CHEMIE AG
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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