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Biomolecules for research                      MATERIAL SAFETY DATA SHEET







Section 1 : Substance Identification



              MMP Inhibitor Profiling Kit, Fluorimetric

     Name:



     Catalog Number:    AK-016





     Company Identification:   BIOMOL International L.P.

                               5120 Butler Pike

                               Plymouth Meeting PA 19462-1202 USA

                               (610) 941-0430 (9am-5pm ET)









Section 2 : Components



     Vial #        Name:                              Contents:      Quantity



     SE180-9090    MMP-1 Enzyme                       30.6 U/µl      2000 U

                   (human recombinant)



     SE237-9090    MMP-2 Enzyme                       3.7 U/µl       150 U

                   (human recombinant)



     SE109-9090    MMP-3 Enzyme                       10 U/µl        300 U

                   (human recombinant)



     SE181-9090    MMP-7 Enzyme                       4.5 U/µl       150 U

                   (human recombinant)



     SE255-9090    MMP-8 Enzyme                       9.2 U/µl       200 U

                   (human recombinant)



     SE244-9090    MMP-9 Enzyme                       2.68 U/µl      130 U

                   (human recombinant)



     SE329-9090    MMP-10 Enzyme                      5 U/µl         150 U

                   (human recombinant)

        SE138-9090      MMP-12 Enzyme                             10 U/µl                                  140 U

                        (human recombinant)



        SE246-9090      MMP-13 Enzyme                             3.45 U/µl                                180 U

                        (human recombinant)



        SE259-9090      MMP-14 Enzyme                             12 U/µl                                  300 U

                        (human recombinant)



                        OmniMMPTM fluorescent substrate

        P126-9090                                                 400 µM in DMSO                           200µl



        P127-9090       Calibration Standard                  40 µM in DMSO                                50 µl

                        (OmniMMP fluorescent control peptide)



        PI115-9090      NNGH                                      1.3 mM in DMSO                           30µl

                        (inhibitor)



        KI-175          Assay Buffer                              50 mM HEPES, 10 mM CaCl2,                2 x 20ml

                                                                  0.05% Brij-35, pH 7.5



        AK016           Instruction Booklet                                                                1 booklet



        KI-110          White 96-Well Plate                       White ½ Volume 96-Well plate             1 plate









 Section 3 : Health Hazards





Please be advised that the physical, chemical and toxicological properties of many of these components have not

yet been fully investigated. Exposure to reagents used in this kit has been shown to cause irritation of the skin. It

is therefore advised that all laboratory personnel handling this product follow standard laboratory safety

procedures. It is recommended that personnel wear safety goggles, gloves, and protective clothing at all times,

and avoid direct contact with the reagents supplied in this kit.









Section 4 : First Aid





        Eye Contact: Check for and remove contact lenses. Flush eyes with running water for at least 15

                minutes separating eyelids. Seek medical attention immediately

        Skin Contact: Wash with soap and water for 15 minutes. Remove contaminated clothing and shoes.

                If irritation or discomfort develops, seek medical attention.

        Inhalation: Remove from exposure. If breathing is difficult, administer oxygen. If breathing stops,

                administer artificial respiration. Seek medical attention if patient feels unwell or develops any

                respiratory symptoms. Provide chemical label and MSDS if possible.

        Ingestion: Remove dentures and clear mouth. If person is conscious, rinse mouth with water. Call

                physician or poison control immediately. Provide chemical label and MSDS information if

                possible.

Section 5 : Fire / Flammability Information



     None of the components of this kit pose a significant risk in case of fire. Fire fighting media should be

     selected to suit other materials involved in the fire. Under fire conditions, hazardous decomposition

     products such as carbon monoxide, carbon dioxide, nitrogen oxides and others may be produced. It is

     recommended that firefighters wear protective gear and self contained breathing apparatus to limit

     exposure.









Section 6 : Spill or Leak Procedures.





     Cleanup Procedures: Wearing appropriate protective gear as outlined under “Protective equipment�

           wipe up spill area and rinse residue down the drain with plenty of water. Wash spill site with soap

           and water.

     Waste Disposal Method: Dilute waste solutions and reagents with water and dispose of in accordance

           with federal, state, and local regulations.







Section 7 : Storage and Handling Precautions



     Protective Equipment: For spill clean up, wear suitable protective clothing, chemical resistant rubber

             gloves, protective shoes, and chemical safety goggles.

     Storage and Handling: The components of this kit should be stored �70°C with the exception of the

             assay buffer which can be stored at 4°C and the 96-well plate and instruction booklet which can be

             stored at room temperature. All components should be kept in tightly closed containers. This

             product should be handled only by qualified experienced professionals. Wash thoroughly after

             handling the materials included in this kit.









Section 8 : Stability and Reactivity Data



     Stability: This material is stable if stored as directed

     Conditions to Avoid: None known

     Incompatibles: Not available









Section 10 : Ecological Data



     Ecotoxicological Information: None Available

The above information is believed to be correct but does not purport to be complete and should be used only as a guide. The burden of

safe use of this material rests entirely with the user.





Emergency Contact:



BIOMOL International L.P.

5120 Butler Pike

Plymouth Meeting, PA 19462 USA



(610) 941-0430







Last Revised : 2/27/07