HEXAMETHYLENE DIISOCYANATE 0278
September 1993
CAS No: 822-06-0 HMDI
RTECS No: MO1740000 1,6-Hexamethylene diisocyanate
UN No: 2281 1,6-Diisocyanatohexane
EC No: 615-011-00-1 C8H12N2O2 / OCN-(CH2)6-NCO
Molecular mass: 168.2
TYPES OF
ACUTE HAZARDS/SYMPTOMS PREVENTION FIRST AID/FIRE FIGHTING
HAZARD/
EXPOSURE
FIRE Combustible. Gives off irritating or toxic NO open flames. Powder, carbon dioxide.
fumes (or gases) in a fire.
EXPLOSION
EXPOSURE PREVENT GENERATION OF MISTS! IN ALL CASES CONSULT A DOCTOR!
AVOID ALL CONTACT!
Inhalation Burning sensation. Cough. Laboured Ventilation, local exhaust, or breathing Fresh air, rest. Artificial respiration may
breathing. Shortness of breath. Sore protection. be needed. Refer for medical attention.
throat.
Skin MAY BE ABSORBED! Redness. Skin Protective gloves. Remove contaminated clothes. Rinse
burns. Blisters. skin with plenty of water or shower. Refer
for medical attention.
Eyes Redness. Pain. Swelling of eyelids. Face shield or eye protection in First rinse with plenty of water for several
combination with breathing protection. minutes (remove contact lenses if easily
possible), then take to a doctor.
Ingestion Do not eat, drink, or smoke during work. Rinse mouth. Refer for medical attention.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Ventilation. Collect EU classification Unbreakable packaging; put breakable
leaking and spilled liquid in sealable containers as far as T Symbol packaging into closed unbreakable
possible. Absorb remaining liquid in sand or inert absorbent R: 23-36/37/38-42/43 container. Do not transport with food and
and remove to safe place. Personal protection: complete S: (1/2-)26-28-38-45 feedstuffs.
protective clothing including self-contained breathing UN classification
apparatus. UN Hazard Class: 6.1
UN Pack Group: II
EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61GT1-II Separated from incompatible materials, see Chemical Dangers, food and feedstuffs.
Cool. Dry. Keep in the dark. Ventilation along the floor.
Prepared in the context of cooperation between the International
IPCS Programme on Chemical Safety and the European Commission 漏
IPCS 2006
International
Programme on
SEE IMPORTANT INFORMATION ON THE BACK.
Chemical Safety
0278 HEXAMETHYLENE DIISOCYANATE
IMPORTANT DATA
Physical State; Appearance Routes of exposure
CLEAR, COLOURLESS LIQUID, WITH PUNGENT ODOUR. The substance can be absorbed into the body by inhalation of its vapour,
by inhalation of its aerosol and through the skin.
Chemical dangers
The substance will polymerize under the influence of temperatures above Inhalation risk
93/C. On combustion, forms toxic and corrosive fumes including nitrogen A harmful contamination of the air will be reached rather slowly on
oxides and hydrogen cyanide (see ICSC 0492). The substance evaporation of this substance at 20/C ; on spraying or dispersing,
decomposes on contact with water to form amine and polyureas. Reacts however, much faster.
violently with acids, alcohols, amines, bases and oxidants. causing fire
and explosion hazard. Attacks copper. Effects of short-term exposure
The substance irritates the eyes, the skin and and the respiratory tract.
Occupational exposure limits Exposure far above the OEL may result in respiratory sensitization.
TLV: 0.005 ppm as TWA; (ACGIH 2004).
MAK: 0.005 ppm, 0.035 mg/m3; Peak limitation category: I(1); Effects of long-term or repeated exposure
sensitization of respiratory tract and skin (Sah); Pregnancy risk group: D; Repeated or prolonged contact may cause skin sensitization. Repeated
(DFG 2006). or prolonged inhalation exposure may cause asthma (see Notes).
PHYSICAL PROPERTIES
Boiling point: 255/C Relative density of the vapour/air-mixture at 20/C (air = 1): 1.00
Melting point: -67/C Flash point: 140/C o.c.
Relative density (water = 1): 1.05 Auto-ignition temperature: 454/C
Solubility in water: reaction Explosive limits, vol% in air: 0.9-9.5
Vapour pressure, Pa at 25/C: 7 Octanol/water partition coefficient as log Pow: 1.08
Relative vapour density (air = 1): 5.8
ENVIRONMENTAL DATA
NOTES
Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical
observation are therefore essential.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance.
Workers exposed to this compound may be sensitized to other isocyanates (asthma).
The odour warning when the exposure limit value is exceeded is insufficient.
Do NOT take working clothes home.
Desmodur H and Desmodur N are trade names.
Card has been partly updated in October 2005. See sections Occupational Exposure Limits, Emergency Response.
Card has been partially updated in July 2007: see Occupational Exposure Limits.
ADDITIONAL INFORMATION
Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible
LEGAL NOTICE for the use which might be made of this information
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