MATERIAL SAFETY DATA SHEET Page: 1
Silybin
Cayman Chemical Company
Printed: 08/27/2005
1180 E. Ellsworth Rd.
Revision: 08/27/2005
Ann Arbor, MI 48108
Date Created: 04/25/2005
1. Product and Company Identification
Product Code: 10006211
Product Name: Silybin
Manufacturer Information
Company Name: Cayman Chemical Company
Emergency Contact: Cayman Chemical Company (800)364-9897
Information: Cayman Chemical Company (734)971-3335
Chemical Family: Inhibitors
CAS Number: 22888-70-6
Synonyms: 2-[2R,3R-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)
-1,4-benzodioxin-6-yl]-2R,3R-dihydro-3,5,7-trihydroxy-4H-1-
benzopyran-4-one; Silibinin; Silymarin;
2. Composition/Information on Ingredients
Hazardous Components (Chemical Name) CAS # Percentage OSHA PEL ACGIH TLV Other Limits
1. Silibin 22888-70-6 100.0 % No data. No data. No data.
3. Hazards Identification
Emergency Overview: No data available.
Route(s) of Entry: Inhalation? Yes Skin? Yes Eyes? Yes Ingestion? Yes Other: Injection
Potential Health Effects (Acute and Chronic): Irritant.
Irritating to eyes, respiratory system and skin.
Irritating to the mucous membranes and upper respiratory tract.
May be harmful by inhalation, ingestion, or skin absorption.
The toxicological properties of this compound have not been fully evaluated.
LD 50/LC 50: Intravenous LD50 (mouse): 1056 mg/kg
Signs and Symptoms Of Exposure: No data available.
4. First Aid Measures
Emergency and First Aid Procedures: If inhaled remove to fresh air. If not breathing, give artificial respiration or give oxygen by trained
personnel. Get immediate medical attention.
If swallowed, wash out mouth with water provided person is conscious. Never give anything by
mouth to an unconscious person. Get medical attention. Do NOT induce vomiting unless directed
to do so by medical personnel.
In case of contact with eyes, hold eyelids apart and flush eyes with plenty of water. After initial
flushings, remove any contact lenses and continue flushing for at least 20 minutes. Have eyes
examined and tested by medical personnel.
In case of skin contact, immediately wash skin with soap and plenty of water. Remove
contaminated clothing. Get medical attention if symptoms occur. Wash clothing before reuse.
5. Fire Fighting Measures
Flash Pt: No data.
Explosive Limits: LEL: No data. UEL: No data.
Autoignition Pt: No data.
Fire Fighting Instructions: As in any fire, wear self-contained breathing apparatus pressure-demand (MSHA/NIOSH
approved or equivalent), and full protective gear to prevent contact with skin and eyes.
Flammable Properties and Hazards: Emits toxic fumes under fire conditions.
ANSI Z400.1 Format
MATERIAL SAFETY DATA SHEET Page: 2
Printed: 08/27/2005
Silybin Revision: 08/27/2005
Extinguishing Media: Use alcohol-resistant foam, carbon dioxide, water, or dry chemical spray when fighting fires
involving this material.
Unsuitable Extinguishing Media: No data available.
6. Accidental Release Measures
Steps To Be Taken In Case Material Is Wear a NIOSH/MSHA approved self-contained breathing apparatus and appropriate personal
Released Or Spilled: protection (rubber boots, safety goggles, and heavy rubber gloves).
Vacuum or sweep up material and place in disposal container.
Avoid raising dust.
After removal, ventilate contaminated area and flush thoroughly with water.
7. Handling and Storage
Hazard Label Information: Avoid contact with skin and eyes. Do not reuse this container. Use with adequate ventilation.
Wash thoroughly after handling.
Precautions To Be Taken in Handling: Avoid breathing (dust, vapor, mist, gas).
Avoid contact with eyes, skin, and clothing.
Avoid prolonged or repeated exposure.
Do not reuse this container.
Use with adequate ventilation.
Wash thoroughly after handling.
Precautions To Be Taken in Storing: Keep tightly closed.
Store at correct temperature.
8. Exposure Controls/Personal Protection
Protective Equipment Summary - Hazard Eye wash station in work area Lab coat Latex disposable gloves Safety glasses Safety
Label Information: shower in work area Vent Hood
Respiratory Equipment (Specify Type): Government approved respirator as conditions warrant.
Eye Protection: Safety glasses
Protective Gloves: Latex disposable gloves
Other Protective Clothing: Lab coat
Engineering Controls (Ventilation etc.): Use process enclosures, local exhaust ventilation, or other engineering controls to control airborne
levels below recommended exposure limits.
Work/Hygienic/Maintenance Practices: Do not take internally.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a
safety shower.
Wash thoroughly after handling.
9. Physical and Chemical Properties
Physical States: [ ] Gas [ ] Liquid [ X ] Solid
Melting Point: No data.
Boiling Point: No data.
Autoignition Pt: No data.
Flash Pt: No data. Method:
Explosive Limits: LEL: No data. UEL: No data.
Specific Gravity (Water = 1): No data.
Vapor Pressure (vs. Air or mm Hg): No data.
Vapor Density (vs. Air = 1): No data.
Evaporation Rate (vs Butyl Acetate=1): No data.
Solubility in Water: 0.5 mg/ml* at 25.0 C
Other Solubility Notes: *DMF:PBS (pH 7.2)(1:9), sol. in EtOH, DMSO & DMF
Percent Volatile: No data.
Corrosion Rate: No data.
Formula: C25H22O10
ANSI Z400.1 Format
MATERIAL SAFETY DATA SHEET Page: 3
Printed: 08/27/2005
Silybin Revision: 08/27/2005
Molecular Weight: 482.40
pH: No data.
Appearance and Odor: A crystalline solid
10. Stability and Reactivity
Stability: Unstable [ ] Stable [ X ]
Conditions To Avoid - Instability: protect from moisture
Incompatibility - Materials To Avoid: strong bases
strong oxidizing agents
Hazardous Decomposition Or Byproducts: carbon dioxide
carbon monoxide
Hazardous Polymerization: Will occur [ ] Will not occur [ X ]
Conditions To Avoid - Hazardous No data available.
Polymerization:
11. Toxicological Information
Toxicological Information: The toxicological effects of this compound have not been thoroughly studied.
Carcinogenicity/Other Information: No data available.
Carcinogenicity: NTP? No IARC Monographs? No OSHA Regulated? No
12. Ecological Information
Ecological Information: Runoff from fire control or dilution water may cause pollution.
13. Disposal Considerations
Waste Disposal Method: Dispose in accordance with local, state and federal regulations.
14. Transport Information
LAND TRANSPORT (US DOT)
DOT Proper Shipping Name: No data available.
Additional Transport Information: Transport in accordance with local, state, and federal regulations.
15. Regulatory Information
US EPA SARA Title III
Hazardous Components (Chemical Name) CAS # Sec.302 (EHS) Sec.304 RQ Sec.313 (TRI) Sec.110
1. Silibin 22888-70-6 No No No No
US EPA CAA, CWA, TSCA
Hazardous Components (Chemical Name) CAS # EPA CAA EPA CWA NPDES EPA TSCA CA PROP 65
1. Silibin 22888-70-6 No No No No
SARA (Superfund Amendments and
Reauthorization Act of 1986) Lists:
EPA SARA Title III Section 302 Extremely Hazardous Chemical with TPQ. * indicates 10000 LB TPQ if not volatile.
Sec.302:
EPA SARA Title III Section 304: CERCLA Reportable + Sec.302 with Reportable Quantity. ** indicates statutory RQ.
Sec.304:
EPA SARA Title III Section 313 Toxic Release Inventory. Note: -Cat indicates a member of a chemical category.
Sec.313:
EPA SARA 110 Superfund Site Priority Contaminant List
Sec.110:
TSCA (Toxic Substances Control
Act) Lists:
Chemical Subject to Significant New Rules (SNURS)
5A(2):
Commercial Chemical Control Rules
6A:
Toxic Substances Subject To Information Rules on Production
8A:
Comprehensive Assessment Information Rules - (CAIR)
8A CAIR:
Preliminary Assessment Information Rules - (PAIR)
8A PAIR:
Records of Allegations of Significant Adverse Reactions
8C:
Health and Safety Data Reporting Rules
8D:
ANSI Z400.1 Format
MATERIAL SAFETY DATA SHEET Page: 4
Printed: 08/27/2005
Silybin Revision: 08/27/2005
Health and Safety Data Reporting Rule Terminations
8D TERM:
Other Important Lists:
EPA Clean Water Act NPDES Permit Chemical
CWA NPDES:
EPA Clean Air Act Hazardous Air Pollutant
CAA HAP:
EPA Clean Air Act Ozone Depleting Chemical (1=CFC, 2=HCFC)
CAA ODC:
California Proposition 65
CA PROP 65:
16. Other Information
Company Policy or Disclaimer
For research use only, not for human or veterinary clinical use.
DISCLAIMER: This information is believed to be accurate and represents the best information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should
make their own investigations to determine the suitability of the information for their particular purposes.
ANSI Z400.1 Format
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