SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/18/2005
Date Updated: 03/07/2004
Version 1.3
Section 1 - Product and Company Information
Product Name 1,4-BUTANEDIOL, REAGENTPLUSTM,
>=99%
Product Number 240559
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
1,4-BUTANEDIOL 110-63-4 No
Formula C4H10O2
Synonyms Agrisynth B1D * Butanediol * Butane-1,4-diol *
1,4-Butylene glycol * 1,4-Dihydroxybutane * DIOL
14B * Sucol B * Tetramethylene 1,4-diol *
1,4-Tetramethylene glycol
RTECS Number: EK0525000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Harmful.
Harmful if swallowed.
Target organ(s): Kidneys. Central nervous system.
HMIS RATING
HEALTH: 1*
FLAMMABILITY: 0
REACTIVITY: 0
NFPA RATING
HEALTH: 1
FLAMMABILITY: 0
REACTIVITY: 0
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
273.2 藲F 134 藲C Method: closed cup
AUTOIGNITION TEMP
370 藲C
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam. Water spray.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Avoid prolonged or repeated exposure. Do not
breathe vapor. Avoid contact with eyes, skin, and clothing.
STORAGE
Suitable: Keep tightly closed.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
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PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
Molecular Weight 90.12 AMU
pH N/A
BP/BP Range 120 - 122 藲C 10 mmHg
MP/MP Range 19 藲C
Freezing Point N/A
Vapor Pressure N/A
Vapor Density 3.1 g/l
Saturated Vapor Conc. N/A
SG/Density 1.014 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point 273.2 藲F 134 藲C Method: closed cup
Explosion Limits N/A
Flammability N/A
Autoignition Temp 370 藲C
Refractive Index 1.446
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents, Acid chlorides, Acid
anhydrides, Reducing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
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Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Kidneys. Central nervous system.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
TOXICITY DATA
Rectal
Man
429 MG/KG
LDLO
Oral
Rat
1525 mg/kg
LD50
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Somnolence (general depressed
activity). Blood:Other changes.
Intraperitoneal
Rat
1070 MG/KG
LD50
Oral
Mouse
2062 mg/kg
LD50
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Somnolence (general depressed
activity). Blood:Other changes.
Intraperitoneal
Mouse
1650 MG/KG
LD50
Oral
Rabbit
2531 mg/kg
LD50
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Somnolence (general depressed
activity). Blood:Other changes.
Oral
Guinea pig
1200 mg/kg
LD50
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Somnolence (general depressed
activity). Blood:Other changes.
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Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: None
Non-Hazardous for Transport: This substance is
considered to be non-hazardous for transport.
IATA
Non-Hazardous for Air Transport: Non-hazardous for air
transport.
Section 15 - Regulatory Information
EU ADDITIONAL CLASSIFICATION
Symbol of Danger: Xn
Indication of Danger: Harmful.
R: 22
Risk Statements: Harmful if swallowed.
S: 36
Safety Statements: Wear suitable protective clothing.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Harmful.
Risk Statements: Harmful if swallowed.
Safety Statements: Wear suitable protective clothing.
US Statements: Target organ(s): Kidneys. Central nervous system.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
ALDRICH - 240559 www.sigma-aldrich.com Page 5
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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