SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/20/2005
Date Updated: 04/04/2004
Version 1.7
Section 1 - Product and Company Information
Product Name SALICYLIC ACID, REAGENTPLUS(TM),
>=99%
Product Number 105910
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
SALICYLIC ACID 69-72-7 No
Formula C7H6O3
Synonyms Acido o-idrossibenzoico (Italian) * Acido
salicilico (Italian) * Benzoic acid, 2-hydroxy- *
o-Hydroxybenzoic acid * 2-Hydroxybenzoic acid *
Keralyt * Kyselina 2-hydroxybenzoova (Czech) *
Kyselina salicylova (Czech) * Orthohydroxybenzoic
acid * Retarder W * SA * SAX * Verrugon
RTECS Number: VO0525000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Harmful.
Harmful if swallowed. Risk of serious damage to eyes.
Target organ(s): Central nervous system. Blood.
HMIS RATING
HEALTH: 2*
FLAMMABILITY: 1
REACTIVITY: 1
NFPA RATING
HEALTH: 2
FLAMMABILITY: 1
REACTIVITY: 1
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
314.6 掳F 157 掳C Method: closed cup
EXPLOSION LIMITS
Lower: 1.1 %
AUTOIGNITION TEMP
570 掳C
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
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SPECIAL REQUIREMENTS
Light sensitive.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Color: White
Form: Fine crystals
Property Value At Temperature or Pressure
Molecular Weight 138.12 AMU
pH 2.4 20 掳C
BP/BP Range 211 掳C 20 mmHg
MP/MP Range 158 掳C
Freezing Point N/A
Vapor Pressure 1 mmHg 114 掳C
Vapor Density 4.8 g/l
Saturated Vapor Conc. N/A
SG/Density 1.44 g/cm3
Bulk Density 800 kg/l
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient Log Kow: 2.21
Decomposition Temp. N/A
Flash Point 314.6 掳F 157 掳C Method: closed cup
Explosion Limits Lower: 1.1 %
Flammability N/A
Autoignition Temp 570 掳C
Refractive Index 1.565
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solvent: 0.1 g/ml EtOH 96% Clear
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Light.
Materials to Avoid: Strong oxidizing agents, Strong bases, Iodine
Iron and iron salts.
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HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes severe eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Central nervous system. Blood.
SIGNS AND SYMPTOMS OF EXPOSURE
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Abdominal pain, nausea, vomiting. symptoms of
overexposure may include rapid respiration, diminished mental
alertness, faulty judgement, rapid fatigue, nausea, loss of
consciousness, coma, and possibly death. Skin rash.
TOXICITY DATA
Oral
Rat
891 mg/kg
LD50
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Muscle weakness.
Inhalation
Rat
> 900 mg/m3
LC50
Skin
Rat
> 2000 mg/kg
LD50
Remarks: Liver:Other changes. Skin and Appendages: Other: Hair.
Intraperitoneal
Rat
157 MG/KG
LD50
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Tremor. Nutritional and Gross Metabolic:Changes
in:Body temperature decrease.
Oral
Mouse
480 mg/kg
LD50
Intraperitoneal
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Mouse
300 MG/KG
LD50
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Respiratory depression.
Intravenous
Mouse
184 MG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Oral
Cat
400 mg/kg
LD50
Oral
Rabbit
1300 mg/kg
LD50
Skin
Rabbit
> 10000 mg/kg
LD50
Inhalation
Mammal
> 300 mg/m3
LC50
IRRITATION DATA
Skin
Rabbit
500 mg
24H
Remarks: Mild irritation effect
Eyes
Rabbit
100 mg
Remarks: Severe irritation effect
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 1050 MG/KG
Route of Application: Oral
Exposure Time: (8-14D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Musculoskeletal system.
Species: Rat
Dose: 700 MG/KG
Route of Application: Oral
Exposure Time: (8-14D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
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Musculoskeletal system.
Species: Rat
Dose: 350 MG/KG
Route of Application: Oral
Exposure Time: (8-14D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord).
Species: Mouse
Dose: 500 MG/KG
Route of Application: Oral
Exposure Time: (9D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - MUTAGEN
Species: Mouse
Route: Oral
Dose: 100 MG/KG
Mutation test: DNA inhibition
Mutation test: Histidine reversion (Ames)
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 40 MG/KG
Route of Application: Oral
Exposure Time: (20-21D PREG)
Result: Maternal Effects: Parturition.
Species: Rat
Dose: 1050 MG/KG
Route of Application: Oral
Exposure Time: (8-14D PREG)
Result: Maternal Effects: Uterus, cervix, vagina. Effects on
Fertility: Post-implantation mortality (e.g., dead and/or
resorbed implants per total number of implants). Effects on
Fertility: Litter size (e.g.; # fetuses per litter; measured
before birth).
Species: Rat
Dose: 380 MG/KG
Route of Application: Subcutaneous
Exposure Time: (9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Specific Developmental Abnormalities: Other
developmental abnormalities.
Species: Mouse
Dose: 1 GM/KG
Route of Application: Oral
Exposure Time: (17D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
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Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 105 mg/l
Test Type: LC50 Fish
Species: Leuciscus idus
Value: 90 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: None
Non-Hazardous for Transport: This substance is
considered to be non-hazardous for transport.
IATA
Non-Hazardous for Air Transport: Non-hazardous for air
transport.
Section 15 - Regulatory Information
EU ADDITIONAL CLASSIFICATION
Symbol of Danger: Xn
Indication of Danger: Harmful.
R: 22 41
Risk Statements: Harmful if swallowed. Risk of serious damage to
eyes.
S: 26 39
Safety Statements: In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
eye/face protection.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Harmful.
Risk Statements: Harmful if swallowed. Risk of serious damage to
eyes.
Safety Statements: In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
eye/face protection.
US Statements: Target organ(s): Central nervous system. Blood.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
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contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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