**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 100-01-6 |4-Nitroaniline | > 98 | 202-810-1 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: T
Risk Phrases: 23/24/25 33 52/53
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Toxic by inhalation, in contact with skin and if swallowed. Danger
of cumulative effects. Harmful to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.Possible risks
of irreversible effects.
Potential Health Effects
Eye:
May cause eye irritation. Vapors may cause eye irritation. May
cause eye injury.
Skin:
May cause skin irritation. Substance is rapidly absorbed through the
skin. If absorbed, may cause symptoms similar to those for ingestion.
Ingestion:
May cause methemoglobinemia, cyanosis (bluish discoloration of skin
due to deficient oxygenation of the blood), convulsions, and death.
Effects may be delayed 2 to 4 hours. Methemoglobinemia is
characterized by dizziness, drowsiness, headache, shortness of
breath, cyanosis (bluish discoloration of skin due to deficient
oxygenation of the blood), rapid heart rate and chocolate-brown
colored blood. May be harmful if swallowed. Alcohol can intensify
effects.
Inhalation:
May cause respiratory tract irritation. May cause effects similar to
those described for ingestion. Inhalation of aniline causes anoxia
due to the formation of methemoglobin.
Chronic:
Prolonged or repeated exposure may cause adverse reproductive
effects. May cause bone marrow abnormalities with damage to blood
forming tissues. May cause anemia and other blood cell
abnormalities. Repeated exposure may cause central nervous system
damage. Chronic exposure may cause liver damage. Adverse reproductive
effects have been reported in animals.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
immediately.
Skin:
Get medical aid immediately. Flush skin with plenty of water for at
least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting
unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Get medical aid.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen.
Notes to Physician:
Absorption of this product into the body may cause cyanosis (bluish
discoloration of skin due to deficient oxygenation of the blood).
Moderate degrees of cyanosis need to be treated only by supportive
measures: bed rest and oxygen inhalation. For methemoglobinemia,
administer oxygen alone or with Methylene Blue depending on the
methemoglobin concentration in the blood. Cleansing of the entire
contaminated area of the body is of utmost importance.
Antidote:
Methylene blue, alone or in combination with oxygen is indicated as
a treatment in nitrite induced methemoglobinemia.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. Dust can be
an explosion hazard when exposed to heat or flame. May decompose
explosively when heated or involved in a fire.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or
alcohol-resistant foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal
container. Clean up spills immediately, observing precautions in the
Protective Equipment section. Wear a self contained breathing
apparatus and appropriate personal protection. (See Exposure
Controls, Personal Protection section). Avoid generating dusty
conditions. Remove all sources of ignition. Provide ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use with adequate ventilation. Minimize dust
generation and accumulation. Ground and bond containers when
transferring material. Use spark-proof tools and explosion proof
equipment. Keep container tightly closed. Do not get on skin or in
eyes. Do not breathe dust.
Storage:
Keep away from sources of ignition. Store in a cool, dry,
well-ventilated area away from incompatible substances. Store
protected from moisture.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local exhaust ventilation to keep airborne concentrations below the
permissible exposure limits.
Exposure Limits
CAS# 100-01-6:
United States OSHA: 1 ppm TWA; 6 mg/m3 TWA
Belgium - TWA: 3 mg/m3 VLE
France - VME: 3 mg/m3 VME
Germany: 1 ppm TWA; 6 mg/m3 TWA
Germany: Skin absorber
Japan: 3 mg/m3 OEL
Malaysia: 3 mg/m3 TWA
Netherlands: 1 ppm MAC; 6 mg/m3 MAC
Russia: 0.1 mg/m3 TWA
Spain: 3 mg/m3 VLA-ED
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Crystalline powder
Color: yellow to brown
Odor: ammonia-like
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 332 deg C
Freezing/Melting Point: 148 deg C
Autoignition Temperature: 500 deg C ( 932.00 deg F)
Flash Point: 199 deg C ( 390.20 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: > 260 deg C
Solubility in water: Insoluble.
Specific Gravity/Density: Not available.
Molecular Formula: NO2C6H4NH2
Molecular Weight: 138.13
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable. However, may decompose if heated.
Conditions to Avoid:
High temperatures, ignition sources, dust generation, moisture.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong reducing agents, strong acids, acid
chlorides, acid anhydrides.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 100-01-6: BY7000000
LD50/LC50:
CAS# 100-01-6: Dermal, guinea pig: LD50 = >500 mg/kg; Oral, mouse:
LD50 = 810 mg/kg; Oral, rat: LD50 = 750 mg/kg.
Carcinogenicity:
4-Nitroaniline -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: NITROANILINES
Hazard Class: 6.1
UN Number: 1661
Packing Group: II
IMO
Shipping Name: NITROANILINES
Hazard Class: 6.1
UN Number: 1661
Packing Group: II
RID/ADR
Shipping Name: NITROANILINES
Hazard Class: 6.1
UN Number: 1661
Packing group: II
USA RQ: CAS# 100-01-6: 5000 lb final RQ; 2270 kg final RQ
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
R 33 Danger of cumulative effects.
R 52/53 Harmful to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
Safety Phrases:
S 28A After contact with skin, wash immediately with
plenty of water.
S 36/37 Wear suitable protective clothing and
gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 100-01-6: 2
Canada
CAS# 100-01-6 is listed on Canada's DSL List.
CAS# 100-01-6 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 100-01-6 is listed on the TSCA inventory.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 11/05/1998 Revision #3 Date: 12/03/2002
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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