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MSDS  : Pyrimidine, 2,4-diamino-6-piperidino-, 3-oxide
CAS  : 38304-91-5
SYNONYMS  : * Alopexil * Alostil * 6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine * 2,4-Diamino-6-piperidinilpirimidina-3-ossido * 2,4-Diamino-6-piperidinopyrimidine 3-oxide * 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine * Loniten * Lonolox * Minossidile * Minoxidil * Minoximen * 6-Piperidino-2,4-diaminopyrimidine 3-oxide * 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide * Prexidil * 2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide * Regaine * Rogaine * Tricoxidil * U-10,858
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : UV8200000
CHEMICAL NAME : Pyrimidine, 2,4-diamino-6-piperidino-, 3-oxide
CAS REGISTRY NUMBER : 38304-91-5
BEILSTEIN REFERENCE NO. : 0886240
REFERENCE : 5-25-12-00317 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 21
MOLECULAR FORMULA : C9-H15-N5-O
MOLECULAR WEIGHT : 209.29
WISWESSER LINE NOTATION : T6N CNJ AO BZ FZ D- AT6NTJ
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Alopexil
* Alostil
* 6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine
* 2,4-Diamino-6-piperidinilpirimidina-3-ossido
* 2,4-Diamino-6-piperidinopyrimidine 3-oxide
* 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine
* Loniten
* Lonolox
* Minossidile
* Minoxidil
* Minoximen
* 6-Piperidino-2,4-diaminopyrimidine 3-oxide
* 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide
* Prexidil
* 2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide
* Regaine
* Rogaine
* Tricoxidil
* U-10,858

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 200 ug/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
Gastrointestinal - nausea or vomiting
REFERENCE :
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago,
IL 60610) V.1- 1908- Volume(issue)/page/year: 146,2075,1986

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 107 ug/kg/3D-I
TOXIC EFFECTS :
Blood - thrombocytopenia
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200
Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year:
92,874,1980

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 69 mg/kg/34W-I
TOXIC EFFECTS :
Cardiac - pericarditis
Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
WJMDA2 Western Journal of Medicine. (44 Gough St., San Francisco, CA 94103)
V.120- 1974- Volume(issue)/page/year: 143,527,1985

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1321 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
39,1,1977

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 759 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
39,1,1977

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 49 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
39,1,1977

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica,
Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year:
121,16,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 560 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica,
Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year:
121,16,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 51 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
39,1,1977

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 19950 mg/kg/95W-C
TOXIC EFFECTS :
Cardiac - changes in heart weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
39(1),1,1977

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 13500 mg/kg/90D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in both tubules and glomeruli
Endocrine - changes in spleen weight
Blood - changes in erythrocyte (RBC) count
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 23,59,1992

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1638 mg/kg/52W-I
TOXIC EFFECTS :
Cardiac - changes in heart weight
Lungs, Thorax, or Respiration - changes in lung weight
Endocrine - changes in spleen weight
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 23,786,1992

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1600 mg/kg/16D-I
TOXIC EFFECTS :
Cardiac - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
39(1),1,1977

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 21840 mg/kg/2Y-C
TOXIC EFFECTS :
Cardiac - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
39(1),1,1977

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 3190 mg/kg/1Y-I
TOXIC EFFECTS :
Cardiac - other changes
REFERENCE :
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert
Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)-
1978- Volume(issue)/page/year: 17,164,1989

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - pig
DOSE/DURATION : 640 mg/kg/32D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Nutritional and Gross Metabolic - changes in sodium
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
39(1),1,1977

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 2080 mg/kg
SEX/DURATION : female 17-21 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 23,774,1992

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 2080 mg/kg
SEX/DURATION : female 17-21 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Effects on Newborn - physical
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 23,774,1992

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 1320 mg/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Effects on Newborn - stillbirth
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 23,756,1992

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 1320 mg/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Effects on Newborn - behavioral
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 23,756,1992

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6163
No. of Facilities: 19 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 679 (estimated)
No. of Female Employees: 350 (estimated)


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
2,4-Pyrimidinediamine,5-((4-(dimethylamino)-3,5-dimethoxyphenyl)methyl)- 56066-63-8
2,4-Pyrimidinediamine, N(sup4)-(2-(dimethylamino)ethyl)-6-methoxy-N(sup2)-methyl-5- (methylthio)-N(sup 2)-phenyl-,monohydrobromide 55417-13-5
2,4-Pyrimidinediamine, N(sup4)-(2-(dimethylamino)ethyl)-N(sup 2),N(sup2)-dimethyl-5- (methylthio)-6-(3-pyridinylmethoxy)-,dihydrobromide 55417-11-3
Pyrimidine,4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-2-((1-methylethyl)thio)- 154496-72-7
2,4-Pyrimidinediamine,6-(4-((5-fluoro-2-benzofuranyl)methyl)-1-piperazinyl)-N,N'-di-2- propenyl-, (E)-2-butenedioate (1:1) 87813-89-6
2,4-Pyrimidinediamine,6-(4-((5-fluoro-2H-1-benzopyran-3-yl)methyl)-1-piperazinyl)-N,N'-di-2- propenyl-, (E)-2-butenedioate (1:1) 87813-91-0
5-Pyrimidinecarboxamide,N-(1-benzyl-4-piperidyl)-4-methoxy-2-methyl-, maleate 72412-54-5
4,6-Pyrimidinediamine,2,2'-(1,6-hexanediylbis(thio))bis- 92629-39-5
2,4-Pyrimidinediamine, 6-(2-methylpropyl)-5-phenyl- 35650-72-7
4,6-Pyrimidinediamine,2,2'-(1,5-pentanediylbis(thio))bis- 92629-38-4
2,4-Pyrimidinediamine, 5-phenyl-6-(phenylmethyl)- 35650-73-8
2,4-Pyrimidinediamine, 6,6'-(1,4-piperazinediyl)bis-,3,3'-dioxide 83540-33-4
Pyrimidine, 2,4-diamino-6-(p-arsenosoanilino)- 34388-37-9
Pyrimidine, 2,4-diamino-5-(p-bromophenyl)-6-methyl- 7331-25-1
Pyrimidine, 2,4-diamino-5-(p-chlorobenzyl)-6-methyl- 7331-23-9
Pyrimidine, 2,4-diamino-5-(p-chlorophenoxy)- 7331-20-6
Pyrimidine, 2,4-diamino-5-(p-chlorophenoxy)-6-methyl- 7331-19-3
5-Pyrimidinecarboxamide,N-((1-benzyl-2-pyrrolidinyl)methyl)-2-(dimethylamino)-4-methoxy-, dihydrochloride 84332-26-3
Pyrimidine,2,4-diamino-5-(3,4-dichlorophenyl)-6-ethyl- 18588-57-3
Pyrimidine,2,4-diamino-5-(3,4-dichlorophenyl)-6-methyl- 7761-45-7
Pyrimidine, 2,4-diamino-6-(2-(diethylamino)ethoxy)- 7520-51-6
Pyrimidine,2,4-diamino-5-(3,5-dimethoxy-4-(2-methoxyethoxy)benzyl)- 53808-87-0
Pyrimidine,2,4-diamino-5-((2,6-dimethoxy-3-pyridyl)methyl)- 65873-69-0
Pyrimidine,2,4-diamino-5-((2,6-dimethoxy-4-pyridyl)methyl)- 65873-57-6
Pyrimidine,2,4-diamino-5-((5,6-dimethoxy-3-pyridyl)methyl)- 52606-05-0
Pyrimidine, 2,4-diamino-6-(2-(dimethylamino)ethoxy)- 7520-50-5
Pyrimidine, 2,4-diamino-6-ethyl-5-phenyl- 27653-49-2
Pyrimidine,2,4-diamino-6-ethyl-5-(p-(trifluoromethoxy)phenyl)- 49561-95-7
5-Pyrimidinecarboxamide,N-((1-benzyl-2-pyrrolidinyl)methyl)-4-methoxy-,dihydrochloride, hydrate 84332-27-4
Pyrimidine, 2,4-diamino-6-isopropyl-5-phenyl- 34062-03-8
Pyrimidine,2,4-diamino-5-((6-methoxy-3-pyridyl)methyl)- 34062-03-8
Pyrimidine, 2,4-diamino-6-methyl-5-(p-nitrobenzyl)- 7331-21-7
Pyrimidine, 2,4-diamino-6-methyl-5-phenyl- 18588-50-6
Pyrimidine, 2,4-diamino-6-methyl-5-phenylazo- 34289-21-9
Pyrimidine, 2,4-diamino-6-(4-methyl-1-piperazinyl)-,3-oxide, dihydrochloride, hydrate 83540-32-3
Pyrimidine, 2,4-diamino-5-phenyl- 18588-49-3
Pyrimidine, 2,4-diamino-5-phenyl-6-propyl- 27653-50-5
Pyrimidine, 2,4-diamino-6-(1-piperazinyl)-, 3-oxide,dihydrochloride, hydrate 83540-31-2
Pyrimidine, 2,4-diamino-6-piperidino-, 3-oxide 38304-91-5
5-Pyrimidinecarboxamide,N-((1-benzyl-2-pyrrolidinyl)methyl)-4-methoxy-2-(methylamino)-, dihydrochloride 84332-25-2
Pyrimidine, 2,4-diamino-5-(2-pyridylmethyl)- 65873-50-9
Pyrimidine, 2,4-diamino-5-(3-pyridylmethyl)- 52606-04-9
Pyrimidine, 2,4-diamino-5-(4-pyridylmethyl)- 65873-56-5
Pyrimidine, 2,4-diamino-5-(3-pyridylmethyl)-, N(sup5)-oxide 65873-74-7
Pyrimidine, 2,4-diamino-5-(4-pyridylmethyl)-, N(sup5)-oxide 65873-75-8
Pyrimidine,2,4-diamino-6-(4-(2-pyridyl)-1-piperazinyl)-,3-oxide, dihydrochloride 83540-38-9
Pyrimidine,2,4-diamino-5-(m-(trifluoromethoxy)benzyl)- 50823-99-9
Pyrimidine,2,4-diamino-5-(m-(trifluoromethyl)benzyl)- 50823-94-4
Pyrimidine, 2,4-diamino-5-(3,4,5-trimethoxybenzyl)- 738-70-5
Pyrimidine, 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-and N'-(5-methyl-3-isoxazolyl) sulfanilamide 8064-90-2

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