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MSDS  : 1(2H)-Pyrimidinecarboxamide, 3,4-dihydro-2,4-dioxo-5-fluoro-N-hexyl-
CAS  : 61422-45-5
SYNONYMS  : * Carmofur * 2,4-Dioxo-5-fluoro-N-hexyl-1,2,3,4-tetrahydro-1-pyrimidinecarboxamide * 2,4-Dioxo-5-fluoro-N-hexyl-3,4-dihydro-1(2H)-pyrimidinecarboxamidme * HCFU * 1-Hexylcarbamoyl-5-fluorouracil * 1-Pyrimidinecarboxamide, 1,2,3,4-tetrahydro-2,4-dioxo-5-fluoro-N-hexyl- * Uracil, 5-fluoro-1-hexylcarbamoyl-
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : UV7714000
CHEMICAL NAME : 1(2H)-Pyrimidinecarboxamide,
3,4-dihydro-2,4-dioxo-5-fluoro-N-hexyl-
CAS REGISTRY NUMBER : 61422-45-5
BEILSTEIN REFERENCE NO. : 0888898
REFERENCE : 5-24-06-00277 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 21
MOLECULAR FORMULA : C11-H16-F-N3-O3
MOLECULAR WEIGHT : 257.30
WISWESSER LINE NOTATION : T6NVMVJ AVM6 EF
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Carmofur
* 2,4-Dioxo-5-fluoro-N-hexyl-1,2,3,4-tetrahydro-1-pyrimidinecarboxamide
* 2,4-Dioxo-5-fluoro-N-hexyl-3,4-dihydro-1(2H)-pyrimidinecarboxamidme
* HCFU
* 1-Hexylcarbamoyl-5-fluorouracil
* 1-Pyrimidinecarboxamide, 1,2,3,4-tetrahydro-2,4-dioxo-5-fluoro-N-hexyl-
* Uracil, 5-fluoro-1-hexylcarbamoyl-

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 1152 mg/kg/14W-I
TOXIC EFFECTS :
Brain and Coverings - encephalitis
Behavioral - hallucinations, distorted perceptions
Behavioral - ataxia
REFERENCE :
JNRYA9 Journal of Neurology. (Springer-Verlag New York, Inc., Service
Center, 44 Hartz Way, Secaucus, NJ 07094) V.207- 1974-
Volume(issue)/page/year: 234,365,1987

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 1749 mg/kg/29W-I
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Behavioral - toxic psychosis
Behavioral - ataxia
REFERENCE :
JNRYA9 Journal of Neurology. (Springer-Verlag New York, Inc., Service
Center, 44 Hartz Way, Secaucus, NJ 07094) V.207- 1974-
Volume(issue)/page/year: 234,365,1987

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 268 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,191,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 93 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,191,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,191,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1129 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China
International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24-
1989- Volume(issue)/page/year: 24,678,1989

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 96 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,191,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 532 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,191,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,191,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 55 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,191,1982

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6 gm/kg/30D-C
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count
Related to Chronic Data - death
Related to Chronic Data - changes in testicular weight
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 17,575,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 182 gm/kg/26W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - interstitial nephritis
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Related to Chronic Data - changes in testicular weight
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 17,575,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1365 mg/kg/13W-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 17,597,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1820 mg/kg/26W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Related to Chronic Data - death
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 17,597,1979

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 275 mg/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 14,1373,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 110 mg/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 14,1373,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 550 mg/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 14,1373,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 3 gm/kg
SEX/DURATION : male 4 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 17,575,1979

** MUTATION DATA **

TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 40 ug/plate
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
Japan) V.29- 1970- Volume(issue)/page/year: 44,96,1985

TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 25730 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 291,29,1993

TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 400 mg/kg
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,363,1980

*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
1(2H)-Pyrimidinecarboxamide,3,4-dihydro-N-(3-((3-(dimethyl(1-methylethyl)silyl)propyl)thio) propyl)-2,4-dioxo-5-fluoro- 103579-44-8
2,4(3H,5H)-Pyrimidinedione,5,5-diethyl-6-((2-(1H-indol-3-yl)ethyl)amino)- 105891-76-7
4,6(1H,5H)-Pyrimidinedione, 5,5-diethyl-2-isopropoxy- 85445-03-0
4,6(1H,5H)-Pyrimidinedione,5,5-diethyl-2-((2-methoxyphenyl)amino)- 106105-05-9
4,6(1H,5H)-Pyrimidinedione,5,5-diethyl-2-((3-methoxyphenyl)amino)- 106105-04-8
4,6(1H,5H)-Pyrimidinedione,5,5-diethyl-2-((4-methoxyphenyl)amino)- 87215-98-3
2,4(3H,5H)-Pyrimidinedione,5,5-diethyl-3-methyl-6-(methylthio)- 105891-91-6
2,4(3H,5H)-Pyrimidinedione,5,5-diethyl-3-methyl-6-(phenylamino)- 87215-91-6
2,4(3H,5H)-Pyrimidinedione,5,5-diethyl-6-((3-methylphenyl)amino)- 87215-89-2
2,4(3H,5H)-Pyrimidinedione,5,5-diethyl-6-((4-methylphenyl)amino)- 87215-88-1
4,6(1H,5H)-Pyrimidinedione,5,5-diethyl-2-((4-methylphenyl)amino)- 87215-97-2
1(2H)-Pyrimidinecarboxamide,3,4-dihydro-N-(2-((2-(dimethyloctylsilyl)ethyl)thio)ethyl)-2,4- dioxo-5-fluoro- 103579-37-9
2,4(3H,5H)-Pyrimidinedione,5,5-diethyl-6-(methylthio)- 65350-89-2
2,4(3H,5H)-Pyrimidinedione,5,5-diethyl-6-(phenylamino)- 87215-86-9
2,4(3H,5H)-Pyrimidinedione,5,5-diethyl-6-((phenylmethyl)amino)- 105891-73-4
4,6(1H,5H)-Pyrimidinedione,5,5-diethyl-2-((phenylmethyl)amino)- 100950-23-0
2,4(1H,3H)-Pyrimidinedione,dihydro-6-(acetyloxy)-5-methyl-5-nitro- 82531-52-0
2,4(1H,3H)-Pyrimidinedione,5,6-dihydro-3-allyl-1-benzyloxy- 30060-40-3
2,4(1H,3H)-Pyrimidinedione,5,6-dihydro-3-allyl-1-(3,4-dimethylbenzyloxy)- 30060-52-7
2,4(1H,3H)-Pyrimidinedione,5,6-dihydro-1-((benzodioxol-5-yl)methoxy)- 30204-47-8
2,4(1H,3H)-Pyrimidinedione,dihydro-6-(benzoyloxy)-5-methyl-5-nitro- 82531-53-1
2,4(1H,3H)-Pyrimidinedione,5,6-dihydro-3-benzyl-1-benzyloxy- 30060-42-5
1(2H)-Pyrimidinecarboxamide,3,4-dihydro-N-(2-((2-(dimethylphenylsilyl)ethyl)thio)ethyl)- dioxo-5-fluoro- 103579-36-8
2,4(1H,3H)-Pyrimidinedione,5,6-dihydro-3-benzyl-1-hydroxy- 30204-59-2
2,4(1H,3H)-Pyrimidinedione, 5,6-dihydro-1-benzyloxy- 30060-35-6
2,4(1H,3H)-Pyrimidinedione,5,6-dihydro-1-benzyloxy-3-methyl- 30060-36-7
2,4(1H,3H)-Pyrimidinedione,5,6-dihydro-1-benzyloxy-5-methyl- 28424-48-8
2,4(1H,3H)-Pyrimidinedione,5,6-dihydro-1-benzyloxy-6-methyl- 28424-48-8
2,4(1H,3H)-Pyrimidinedione,5,6-dihydro-1-benzyloxy-6-phenyl- 30060-41-4
2,4(1H,3H)-Pyrimidinedione,dihydro-1-(2-(4-butoxyphenyl)ethyl)- 88655-21-4
2,4(1H,3H)-Pyrimidinedione,dihydro-1-((4-butoxyphenyl)methyl)-5-methyl- 62554-14-7
4,6(3H,5H)-Pyrimidinedione,1,2-dihydro-5-butyl-1,3-diphenyl- 62554-14-7
2,4(1H,3H)-Pyrimidinedione,5,6-dihydro-1-(p-chlorobenzyloxy)- 30060-48-1
1(2H)-Pyrimidinecarboxamide,3,4-dihydro-N-(3-((3-(dimethylphenylsilyl)propyl)thio)propyl)- 2,4-dioxo-5-fluoro- 103579-49-3
2,4(1H,3H)-Pyrimidinedione,5,6-dihydro-1-(p-chlorobenzyloxy)-5-methyl- 30060-49-2
4,6(1H,5H)-Pyrimidinedione,dihydro-1-(3-chloro-2-(2-chlorophenyl)-4-oxo-1-azetidinyl)-3-((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)amino)acetyl)-2- thioxo- 151921-15-2
2,4(1H,3H)-Pyrimidinedione,dihydro-1-(4-chloro-2-methylphenyl)-3-methyl- 77385-01-4
4,6(1H,5H)-Pyrimidinedione,dihydro-5-(((2-chloro-4-nitrophenyl)amino)methyl)-1-(2-methylphenyl)-3-(4-phenyl-2-thiazolyl)-2-thioxo- 139356-79-9
4,6(1H,5H)-Pyrimidinedione,dihydro-5-(((2-chloro-4-nitrophenyl)amino)methyl)-1-phenyl-3- (4-phenyl-2-thiazolyl)-2-thioxo- 139356-73-3
4,6(1H,5H)-Pyrimidinedione,dihydro-1-(3-chloro-2-oxo-4-phenyl-1-azetidinyl)-3-(((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)amino)acetyl)-2-thioxo- 151921-14-1
4,6(1H,5H)-Pyrimidinedione,dihydro-1-(3-chloro-2-oxo-4-(2-phenylethenyl)-1-azetidinyl)-3-(((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)amino)acetyl)-2 -thioxo- 151921-16-3
4,6(1H,5H)-Pyrimidinedione,dihydro-5-(((3-chlorophenyl)amino)methyl)-1-(2-methylphenyl)-3-(4-phenyl-2 -thiazolyl)-2-thioxo- 139356-76-6
4,6(1H,5H)-Pyrimidinedione,dihydro-5-(((4-chlorophenyl)amino)methyl)-1-(2-methylphenyl)-3-(4-phenyl-2 -thiazolyl)-2-thioxo- 139356-77-7
4,6(1H,5H)-Pyrimidinedione,dihydro-5-(((4-chlorophenyl)amino)methyl)-1-(2-methylphenyl)-3-(2-pyridiny l)-2-thioxo- 156338-83-9
5-Pyrimidinecarboxamide,2-amino-4-methoxy-N-(8-(p-nitrobenzyl)-3-beta-nortropanyl)-, monomaleate 84923-22-8
1(2H)-Pyrimidinecarboxamide,3,4-dihydro-2,4-dioxo-5-fluoro-N-hexyl- 61422-45-5
4,6(1H,5H)-Pyrimidinedione,dihydro-5-(((4-chlorophenyl)amino)methyl)-1-phenyl-3-(4-phenyl-2- thiazolyl)-2-thioxo- 139356-71-1
4,6(1H,5H)-Pyrimidinedione,dihydro-5-(((4-chlorophenyl)amino)methyl)-1-phenyl-3-(2- pyridinyl)-2-thioxo- 156338-82-8
2,4(1H,3H)-Pyrimidinedione,dihydro-1-(4-chlorophenyl)-3-methyl- 77385-17-2
2,4(1H,3H)-Pyrimidinedione,dihydro-3-(2-chlorophenyl)-1-methyl- 77385-02-5

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