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MSDS  : Pyrrolidine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene )-1-ethyl-2-methyl-, hydrochloride
CAS  : 16378-22-6
SYNONYMS  : * Piroheptine hydrochloride * Trimol
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : UY0870000
CHEMICAL NAME : Pyrrolidine,
3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene
)-1-ethyl-2-methyl-, hydrochloride
CAS REGISTRY NUMBER : 16378-22-6
LAST UPDATED : 199204
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C22-H25-N.Cl-H
MOLECULAR WEIGHT : 339.94
WISWESSER LINE NOTATION : L C676 BY&T&J BU- CT5N CYTJ A2 B1 &GH
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Piroheptine hydrochloride
* Trimol

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 4,467,1973

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 4,467,1973

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 330 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 22,961,1972

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 16 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 4,467,1973

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 127 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 22,961,1972

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 78 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 22,961,1972

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 91 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 22,961,1972

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 19 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 4,467,1973

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 195 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 6,941,1972

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 12500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 6,941,1972

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 383 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 6,941,1972

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 6200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 6,941,1972

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3250 mg/kg/30D-I
TOXIC EFFECTS :
Blood - changes in cell count (unspecified)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 6,941,1972

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 19500 mg/kg/26W-I
TOXIC EFFECTS :
Cardiac - changes in heart weight
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 6,941,1972

*** END OF RECORD ***
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NAMECAS
1,2-Pyrrolidinedicarboxamide, N(sup1)-(2-chloroethyl)-N(sup 1)-nitroso-, (S)- 81965-44-8
1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, L- 1148-11-4
1,2-Pyrrolidinedicarboxylic acid, 1-benzyl2-(1,2-dibromoethyl) ester 64187-33-3
1,2-Pyrrolidinedicarboxylic acid, 1-benzylp-nitrophenyl ester, L- 3304-59-4
1-Pyrrolidineacetamide, 4-hydroxy-2-oxo- 62613-82-5
1,2-Pyrrolidinedicarboxylic acid, 2-ethenyl1-(phenylmethyl) ester, (S)- 64187-32-2
2,2-Pyrrolidinedicarboxylic acid, 3-isopropyl-5-oxo-,diethyl ester 2445-91-2
Pyrrolidine,1-(2-(7,8-dichloro-11H-dibenzo(b,e)(1,4)dioxepin-11-yl)ethyl)-, hydrochloride, (+-)- 81320-49-2
Pyrrolidine, 3,4-dichloro-N-nitroso- 59863-59-1
Pyrrolidine, 2-((3,4-dichlorophenyl)imino)-1-propyl- 27050-40-4
Pyrrolidine, 2-(2,2-dicyclohexylethyl)-,hydrochloride 63722-64-5
Pyrrolidine,1-(4-(diethylamino)-2,2-diphenylbutyryl)-,monohydrochloride 63722-64-5
Pyrrolidine, 1-(6-(diethylamino)-2-hexynyl)- 6628-90-6
Pyrrolidine,1-(N,N-diethylglycyl)-2,2,5,5-tetramethyl- 53725-38-5
Pyrrolidine,1-(2-(4-(2,2-diethyl-7-methoxy-3-phenyl-2H-1-benzopyran-4-yl)phenoxy)ethyl )-, hydrochloride 57897-58-2
1-Pyrrolidineacetamide, 3-hydroxy-2-oxo-, (+-)- 85404-68-8
Pyrrolidine,1-(6,7-dihydro-5H-benzocyclohepten-7-yl)-,(E)-2-butenedioate (2:1) 62819-73-2
Pyrrolidine,3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-ethyl-2-methyl-, hydrochloride 16378-22-6
Pyrrolidine,3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidenemethyl)-1-methyl, 29128-69-6
Pyrrolidine,1-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)-3-(methylamino)- 69159-51-9
Pyrrolidine,1-(4-((10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)oxy)-2-butynyl)-, maleate 69159-51-9
Pyrrolidine,1-(2-((10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)oxy)ethyl)-, oxalate 15475-33-9
Pyrrolidine,3-((10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)oxy)-1-methyl-, maleate (1:1) 1057-59-6
Pyrrolidine,1-((3a,12b-dihydrodibenzo(b,f)-1,3-dioxolo(4,5-d)oxepin-2-yl)methyl)- 84646-78-6
Pyrrolidine,1-(2-(6,11-dihydrodibenz(b,e)oxepin-6-yl)ethyl)-,(+-)-, (E)-2-butenedioate (1:1) 86640-22-4
Pyrrolidine,1-(2-(4-(3,4-dihydro-2,2-diethyl-7-methoxy-3-phenyl-2H-1-benzopyran-4-yl) phenoxy)ethyl)-, hydrochloride 86640-22-4
1-Pyrrolidineacetamide, 3-hydroxy-2-oxo-, (R)- 85348-47-6
Pyrrolidine,1-((3,4-dihydro-6,7-dimethoxy-1H-2-benzopyran-1-yl)methyl)-, hydrochloride 70100-63-9
Pyrrolidine,1-(2,3-dihydro-2,2-dimethyl-3-benzofuranyl)- 58774-94-0
Pyrrolidine,1-((3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)acetyl)-, monohydrochloride, (Z)- 126356-29-4
Pyrrolidine,1-(2-(4-(3,4-dihydro-2,2-dimethyl-7-methoxy-4-phenyl-2H-1-benzopyran-3-yl) phenoxy)ethyl)-, (E)- 84394-37-6
Pyrrolidine,1-(2-(4-(3,4-dihydro-2,2-dimethyl-7-methoxy-3-phenyl-2H-1-benzopyran-4-yl) phenoxy)ethyl)-, hydrochloride,(E)- 84394-37-6
Pyrrolidine,1-(3-(4-(3,4-dihydro-2,2-dimethyl-7-methoxy-3-phenyl-2H-1-benzopyran-4-yl) phenoxy)propyl)-,hydrochloride, (E)- 84394-09-2
Pyrrolidine,1-(2-(4-(3,4-dihydro-7-methoxy-2,2-dimethyl-3-phenyl-2H-1-benzopyran-4-yl) phenoxy)ethyl)-, cis- 51423-20-2
Pyrrolidine,1-(2-(4-(3,4-dihydro-7-methoxy-2,2-dimethyl-3-phenyl-2H-1-benzopyran-4-yl) phenoxy)ethyl)-, hydrochloride,trans-(-)- 79386-05-3
Pyrrolidine,1-(2-(4-(3,4-dihydro-7-methoxy-2,2-dimethyl-3-phenyl-2H-1-benzopyran-4-yl) phenoxy)ethyl)-, hydrochloride,trans-(+)- 92083-15-3
Pyrrolidine,1-(2-(4-(3,4-dihydro-7-methoxy-2,2-dimethyl-3-phenyl-2H-1-benzopyran-4-yl) phenoxy)ethyl)-, hydrochloride,trans-(+-)- 103150-29-4
1-Pyrrolidineacetamide, 3-hydroxy-2-oxo-, (S)- 85348-46-5
Pyrrolidine,1-(2-(4-(3,4-dihydro-7-methoxy-3-phenyl-2H-1-benzopyran-4-yl)phenoxy)ethyl )-, (E)- 33382-08-0
Pyrrolidine,1-(2-(4-(3,4-dihydro-7-methoxy-3-phenyl-2H-1-benzopyran-4-yl)phenoxy)ethyl )-, (Z)- 33382-06-8
Pyrrolidine,1-(2-(p-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy)ethyl)- 1845-11-0
Pyrrolidine,1-(2-(p-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy)ethyl)-, hydrochloride 1847-63-8
Pyrrolidine,1-((1,2-dihydro-2-methyl-1-oxo-4-isoquinolinyl)carbonyl)- 148581-48-0
Pyrrolidine,1-((10,11-dihydro-11-(4-methyl-1-piperazinyl)dibenzo(b,f)thiepin-2-yl) sulfonyl)-, methanesulfonate,hydrate (1:2:1) 51723-65-0
Pyrrolidine,1-(3-(3,4-dihydro-2-naphthalenyl)-1-oxo-2,3-diphenyl-2-propenyl)- 58271-28-6
Pyrrolidine,1-((5,6-dihydro-6-oxo-3-phenanthridinyl)carbonyl)- 39180-44-4
Pyrrolidine,1-((2,3-dihydro-5-oxo-5H-thiazolo(3,2-a)pyrimidin-6-yl)carbonyl)- 93501-42-9
Pyrrolidine,1-(((1,2-dihydro-5,6,17,19,21-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-2,7-(epoxypentadeca(1,11,13)trienimino)naphtho(2,1- b)furan-9-yl)oxy) acetyl)-,21-acetate 13929-40-3
1-Pyrrolidineacetamide, 4-hydroxy-2-oxo-, (+-)- 68567-97-5
Pyrrolidine,1-(2-(p-(6,7-dihydro-2-phenyl-5H-indeno(5,6-b)furan-3-yl)phenoxy)ethyl)-, hydrochloride 25439-45-6

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