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MSDS  : 2(1H)-Quinazolinone, 1-isopropyl-7-methyl-4-phenyl-
CAS  : 22760-18-5
SYNONYMS  : * Biarison * Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone * Proquazone * 2(1H)-Quinazolinone, 7-methyl-1-(1-methylethyl)-4-phenyl- * RU 43715 * Sandoz 43-715 * SaH 43-715
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : VA3530000
CHEMICAL NAME : 2(1H)-Quinazolinone, 1-isopropyl-7-methyl-4-phenyl-
CAS REGISTRY NUMBER : 22760-18-5
BEILSTEIN REFERENCE NO. : 0889725
REFERENCE : 5-24-04-00375 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 8
MOLECULAR FORMULA : C18-H18-N2-O
MOLECULAR WEIGHT : 278.38
WISWESSER LINE NOTATION : T66 BNVNJ BY1&1 ER& I1
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Biarison
* Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone
* Proquazone
* 2(1H)-Quinazolinone, 7-methyl-1-(1-methylethyl)-4-phenyl-
* RU 43715
* Sandoz 43-715
* SaH 43-715

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 759 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 375 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - antipsychotic
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 930 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 339 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - somnolence (general depressed activity)
Behavioral - changes in motor activity (specific assay)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 34,879,1984

TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >800 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 260 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - antipsychotic
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 9100 mg/kg/13W-C
TOXIC EFFECTS :
Gastrointestinal - other changes
Related to Chronic Data - death
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - pig
DOSE/DURATION : 6916 mg/kg/26W-C
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from stomach
Blood - changes in erythrocyte (RBC) count
Related to Chronic Data - death
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980

*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
4(3H)-Quinazolinone,2-(4-(((4-chlorophenyl)methylene)amino)phenyl)-3-(4-(4-oxo- 2-(phenylimino)-3-thiazolidinyl)phenyl)- 83408-72-4
4(3H)-Quinazolinone,3-(4-(((2-hydroxy-3-nitrophenyl)methylene)amino)phenyl)-2-methyl- 36934-38-0
4(3H)-Quinazolinone,3-(5-((2-hydroxy-3-(phenylamino)propyl)thio)-1,3,4-thiadiazol-2-yl)- 6-iodo-2-methyl- 135575-64-3
4(3H)-Quinazolinone,3-(5-((2-hydroxy-3-(phenylamino)propyl)thio)-1,3,4-thiadiazol-2-yl)- 2-methyl- 135575-53-0
4(3H)-Quinazolinone,3-(4-(((2-hydroxyphenyl)methylene)amino)phenyl)-6-iodo-2-methyl- 36933-78-5
4(3H)-Quinazolinone,3-(4-(((2-hydroxyphenyl)methylene)amino)phenyl)-2-methyl- 36934-37-9
4(3H)-Quinazolinone, 3-(o-hydroxyphenyl)-2-methyl-,hydrochloride 1789-08-8
4(3H)-Quinazolinone,3-((5-(4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)methyl)-2-methyl- 106924-06-5
4(3H)-Quinazolinone,3-(2-(3-hydroxyphenyl)-4-oxo-3-thiazolidinyl)-2-phenyl- 106873-19-2
4(3H)-Quinazolinone,3-(2-(4-hydroxyphenyl)-4-oxothiazolidin-3-yl)-2-phenyl- 106873-20-5
4(3H)-Quinazolinone,3-(3-(2-hydroxy-3-(4-phenyl-1-piperazinyl)propoxy)phenyl)-2-methyl- 106873-20-5
4(3H)-Quinazolinone,2-(((4-((2-chlorophenyl)methylene)-5-oxo-2-thioxo-1-imidazolidinyl) imino)methyl)-3-phenyl- 169471-14-1
4(3H)-Quinazolinone,3-(4-hydroxy-1-piperazinylmethyl)-, dihydrochloride 68638-38-0
4(3H)-Quinazolinone,3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-,(2S-trans)- 24159-07-7
4(3H)-Quinazolinone,2-(o-hydroxystyryl)-3-(2-methyl-1-benzimidazolyl)- 24159-07-7
4(3H)-Quinazolinone, 3-(2-hydroxy-p-tolyl)-2-methyl- 36556-91-9
4(3H)-Quinazolinone, 3-(4-hydroxy-o-tolyl)-2-methyl- 5060-52-6
4(3H)-Quinazolinone,2-(2-hydroxy-3-trichloropropyl)-3-(o-tolyl)-,hydrochloride 1772-87-8
4(3H)-Quinazolinone,2-((2-imidazolin-2-ylmethyl)thio)-3-phenyl-,monohydrobromide 61555-05-3
4(3H)-Quinazolinone,2-((2-imidazolin-2-ylthio)methyl)-3-o-tolyl-,monohydrobromide 61555-02-0
4(3H)-Quinazolinone,3-(1H-indol-3-ylmethyl)-2-methyl- 88514-47-0
4(3H)-Quinazolinone,7-iodo-2-((o-methoxyphenoxy)methyl)-3-(2-pyridyl)- 75057-66-8
4(3H)-Quinazolinone, 3-(6-chloro-o-tolyl)-2-methyl- 75057-66-8
4(3H)-Quinazolinone,7-iodo-2-((2-methoxyphenoxy)methyl)-3-(2-thiazolyl)- 75057-65-7
4(3H)-Quinazolinone,6-iodo-2-methyl-3-(2-((1-methylethyl)amino)ethyl)- 77300-93-7
4(3H)-Quinazolinone,6-iodo-2-methyl-3-(2-methylphenyl)- 4449-73-4
4(3H)-Quinazolinone, 6-iodo-2-methyl-3-phenyl- 4449-71-2
4(3H)-Quinazolinone,6-iodo-2-((4-methylphenyl)methoxy)-3-(2-pyridinyl)- 85178-77-4
4(3H)-Quinazolinone,3-(3-iodo-2-methylphenyl)-2-methyl- 1897-83-2
4(3H)-Quinazolinone,6-iodo-3-(2-(1-((1-methyl-4-piperidinyl)methyl)-1H-benzimidazol-2-yl)- phenyl)-2-phenyl- 91045-25-9
4(3H)-Quinazolinone,6-iodo-3-(2-(1-((4-methyl-1-piperidinyl)methyl)-1H-benzimidazol-2-yl)- phenyl)-2-phenyl- 91045-24-8
4(3H)-Quinazolinone,6-iodo-2-methyl-3-(2-pyrimidinyl)- 37905-58-1
4(3H)-Quinazolinone,6-iodo-3-(2-(1-(4-morpholinylmethyl)-1H-benzimidazol-2-yl)phenyl)- 2-phenyl- 91045-23-7
4(3H)-Quinazolinone,2-(((4-((2-methoxyphenyl)methylene)-5-oxo-2-thioxo-1-imidazolidinyl) imino)methyl)-3-phenyl- 169471-15-2
4(3H)-Quinazolinone,6-iodo-2-(phenylmethoxy)-3-(2-pyridinyl)- 85178-76-3
4(3H)-Quinazolinone,6-iodo-2-phenyl-3-(2-(1-(1-piperidinylmethyl)-1H-benzimidazol-2-yl) phenyl)- 91045-22-6
4(3H)-Quinazolinone, 3-isooctyl- 91045-22-6
4(3H)-Quinazolinone, 3-isopropyl-2-(p-methoxyphenyl)- 32700-76-8
2(1H)-Quinazolinone, 1-isopropyl-7-methyl-4-phenyl- 22760-18-5
4(3H)-Quinazolinone,3-(4-isopropyl-1-piperazinylmethyl)-, dihydrochloride 68638-37-9
4(3H)-Quinazolinone,3-(5-isopropyl-1,3,4-thiadiazolyl)-2-methyl- 3060-19-3
4(3H)-Quinazolinone, 6-mercapto-3-methyl- 3060-19-3
4(3H)-Quinazolinone, 6-methoxy-3-methyl- 3060-19-3
4(3H)-Quinazolinone, 2-methoxymethyl-3-(o-tolyl)- 31383-55-8
4(3H)-Quinazolinone,2-(((4-((4-methoxyphenyl)methylene)-5-oxo-2-thioxo-1-imidazolidinyl) imino)methyl)-3-phenyl- 169471-16-3
4(3H)-Quinazolinone,3-(2-methoxy-4-nitrophenyl)-2-methyl- 340-52-3
4(3H)-Quinazolinone,3-(2-methoxy-5-nitrophenyl)-2-methyl- 340-52-3
4(3H)-Quinazolinone,3-(4-methoxy-2-nitrophenyl)-2-methyl- 340-52-3
4(3H)-Quinazolinone,2-((o-methoxyphenoxy)methyl)-3-(2-thiazolyl)- 73342-49-1
4(3H)-Quinazolinone,2-((2-methoxyphenoxy)methyl)-3-(2-pyridinyl)- 73342-50-4

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