*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : VD2275000
CHEMICAL NAME : Quinoxaline, 1,4-dioxide
CAS REGISTRY NUMBER : 2423-66-7
LAST UPDATED : 199512
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C8-H6-N2-O2
MOLECULAR WEIGHT : 162.16
WISWESSER LINE NOTATION : T66 BN ENJ BO EO
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Chindoxin
* Chinoxalin-1,4-dioxid
* Grofas
* Quindoxin
* Quinoxaline dioxide
* Quinoxaline di-N-oxide
* Quinoxaline 1,4-di-N-oxide
* USAF H-1
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku,
Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952-
Volume(issue)/page/year: 30,26,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku,
Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952-
Volume(issue)/page/year: 30,26,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2970 mg/kg/12D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 8,286,1953
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 1500 mg/kg/3D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 8,286,1953
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5400 mg/kg/77W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
Liver - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
55,137,1975
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 5 ug/plate
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA,
1255 Howard St., San Francisco, CA 94103) V.6- 1958-
Volume(issue)/page/year: 27,1954,1979
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 ug/disc
REFERENCE :
AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for
Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972-
Volume(issue)/page/year: 20,151,1981
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 203,81,1988
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 20 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 139,199,1984
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
*** END OF RECORD ***
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| ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| | NAME | CAS |
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beta-D-Ribofuranoside,2,3-dihydroxypropyl-5-deoxy-5-(dimethylarsinyl)-,(R)-
| 103476-61-5 |
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Rifomycin SV,8-(N-(4-methyl-1-piperazinyl)formidoyl)-
| 13292-46-1 |
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Rikkunshi-toSUBSTANCE DEFINITION :A mixture of eight herbal medicines, i.e., Atractylodis Lanceae Rhizoma,Ginseng Radix, Pinelliae Tuber, Hoelen, Zizyphi Fructus, Aurantii NobilisPericarpium, Glycyrrhizae Radix and Zingiberis Rhizoma (4:4:4:4:2:2:1:0.5)REFERENCE :YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu SaiensuShuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
| 13292-46-1 |
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Rimmel mahogany silkSUBSTANCE DEFINITION :A synthetic food colour currently used in foodsREFERENCE :FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. Forpublisher information, see FCTOD7. Volume(issue)/page/year: 18,215,1980
| 13292-46-1 |
|
Rimocidin
| 1393-12-0 |
|
Rinamycin
| 56749-39-4 |
|
Ringer's solution
| 8026-10-6 |
|
Ringer's solution, 5% glucose in acetated
| 8026-10-6 |
|
Quinoxaline, 2,3-dimethyl-6-fluoro-, 1,4-dioxide
| 84044-35-9 |
|
Ringer's solution, 5% maltose in lactated, MI-5L
| 84044-35-9 |
|
Rinorea bengalensis (Wall.) O.Ktze., extractSUBSTANCE DEFINITION :Plant belonging to the family ViolaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 28,619,1990
| 84044-35-9 |
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Ristocetin
| 1404-55-3 |
|
Ristocetin B
| 1405-59-0 |
|
Ristomycin
| 11006-74-9 |
|
Ristomycin A
| 11021-66-2 |
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Ristomycin A aglycone,34-O-(3-amino-2,3,6-trideoxy-alpha-L-ribo-hexopyranosyl)-
| 73412-13-2 |
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Ristomycin A aglycone,7-demethyl-64-O-demethyl-19-deoxy-22,31-dichloro-
| 89139-42-4 |
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Ristomycin A aglycone,7-demethyl-64-O-demethyl-19-deoxy-11-O-galactosyl-22,31,35-trichloro-
| 89140-21-6 |
|
Ristomycin A aglycone,7-demethyl-64-O-demethyl-19-deoxy-22,31,45-trichloro-
| 89139-41-3 |
|
2,3-Quinoxalinediol
| 15804-19-0 |
|
Ristomycin, sulfate
| 11140-99-1 |
|
Rivea hypocrateriformis Choisy, fruit extractSUBSTANCE DEFINITION :Plant belonging to the family ConvolvulaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 18,594,1980
| 11140-99-1 |
|
RN 30/9SUBSTANCE DEFINITION :An extract of crataegusREFERENCE :PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 43,105,1981
| 11140-99-1 |
|
Ro 413
| 102583-50-6 |
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Ro 7-4100
| 102583-54-0 |
|
Ro 22-8181
| 93354-90-6 |
|
Ro 5-9110/1
| 102583-51-7 |
|
Ro 7-1728/1
| 102583-52-8 |
|
Ro 7-2431/1
| 102583-53-9 |
|
Robaveron
| 102583-53-9 |
|
Quinoxaline, 1,4-dioxide
| 2423-66-7 |
|
Robinia pseudoacacia Linn., extractSUBSTANCE DEFINITION :Plant belonging to the family LeguminosaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 2423-66-7 |
|
Robitussin-DM
| 72101-06-5 |
|
ROC-101SUBSTANCE DEFINITION :An herbal preparation composed of a mixture of three different plantsindigenous to IndiaREFERENCE :IJMRAQ Indian Journal of Medical Research. (Indian Council of MedicalResearch, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-Volume(issue)/page/year: 60,1054,1972
| 72101-06-5 |
|
Rochem oil spill remover (wsa)
| 75602-95-8 |
|
Ronpacon cerebral 280
| 75602-95-8 |
|
Roridin A
| 14729-29-4 |
|
Rose brunonii Lindl., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family RosaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 14729-29-4 |
|
Rose davurica Pallas, fruit flavonoids
| 14729-29-4 |
|
Rose involucrata Roxb., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family RosaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 18,594,1980
| 14729-29-4 |
|
Rose leschenaultii Red. & Thory ex Wt. & Arn.,extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family RosaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 24,48,1986
| 14729-29-4 |
|
2H-Quinolizin-3-axial-ol,octahydro-3-equatorial-phenyl-
| 57120-84-0 |
|
Quinoxaline, 2,3-diphenyl-, 1,4-dioxide
| 5227-56-5 |
|
Rose macrophylla Lindl., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family RosaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 11,43,1973
| 5227-56-5 |
|
Rosa multiflora, Thunb, root extract
| 5227-56-5 |
|
Rose sericea Lindl., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family RosaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 15,208,1977
| 5227-56-5 |
|
Rose webbiana Wall., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family RosaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 5227-56-5 |
|
Rose bengal
| 11121-48-5 |
|
Roselle color
| 11121-48-5 |
|
Rosemary oil
| 8000-25-7 |
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