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MSDS  : Salicylic acid, 4-amino-, sodium salt
CAS  : 133-10-8
SYNONYMS  : * p-Aminosalicylate sodium * p-Aminosalicylic acid sodium salt * Bactylan * Benzoic acid, 4-amino-2-hydroxy-, monosodium salt * Lepasen * Monosodium T4-amino-2-hydroxybenzoate * Natri-pas * Nippas * Pamisyl sodium * Pasade * Pasalon-rakeet * PAS-Na * Pasnal * Passodico * Salvis * Sanipirol * Sodiopas * Sodium aminosalicylate * Sodium p-aminosalicylate * Sodium p-aminosalicylic acid * Sodium PAS * Tubersan
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : VO1700000
CHEMICAL NAME : Salicylic acid, 4-amino-, sodium salt
CAS REGISTRY NUMBER : 133-10-8
LAST UPDATED : 199701
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C7-H6-N-O3.Na
MOLECULAR WEIGHT : 175.13
WISWESSER LINE NOTATION : ZR CQ DVO &-NA-
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* p-Aminosalicylate sodium
* p-Aminosalicylic acid sodium salt
* Bactylan
* Benzoic acid, 4-amino-2-hydroxy-, monosodium salt
* Lepasen
* Monosodium T4-amino-2-hydroxybenzoate
* Natri-pas
* Nippas
* Pamisyl sodium
* Pasade
* Pasalon-rakeet
* PAS-Na
* Pasnal
* Passodico
* Salvis
* Sanipirol
* Sodiopas
* Sodium aminosalicylate
* Sodium p-aminosalicylate
* Sodium p-aminosalicylic acid
* Sodium PAS
* Tubersan

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZENBAX Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie,
Organische Chemie, Biochemie, Biophysik, Biologie. (Tuebingen, Fed. Rep.
Ger.) V.2B-27B, 1947-1972. For publisher information, see ZNCBDA.
Volume(issue)/page/year: 6B,183,1951

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4950 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZENBAX Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie,
Organische Chemie, Biochemie, Biophysik, Biologie. (Tuebingen, Fed. Rep.
Ger.) V.2B-27B, 1947-1972. For publisher information, see ZNCBDA.
Volume(issue)/page/year: 6B,183,1951

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 6900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZENBAX Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie,
Organische Chemie, Biochemie, Biophysik, Biologie. (Tuebingen, Fed. Rep.
Ger.) V.2B-27B, 1947-1972. For publisher information, see ZNCBDA.
Volume(issue)/page/year: 6B,183,1951

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3850 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland)
V.18-24, 1966-72. For publisher information, see PJPPAA.
Volume(issue)/page/year: 23,383,1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
Volume(issue)/page/year: 146,466,1952

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3380 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book
Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For
publisher information, see ZYZAEU. Volume(issue)/page/year: 15(12),17,1980

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 247 mg/kg
SEX/DURATION : female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland)
V.18-24, 1966-72. For publisher information, see PJPPAA.
Volume(issue)/page/year: 23,383,1971

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 69300 ug/kg
SEX/DURATION : female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland)
V.18-24, 1966-72. For publisher information, see PJPPAA.
Volume(issue)/page/year: 23,383,1971

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE : 40 mg/kg
SEX/DURATION : female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland)
V.18-24, 1966-72. For publisher information, see PJPPAA.
Volume(issue)/page/year: 23,383,1971

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 1 mg/plate
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 19,939,1981

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 600 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 48,215,1977

TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Ascites tumor
DOSE/DURATION : 6 pph
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211,
1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year:
335,69,1974

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6099
No. of Facilities: 16 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 370 (estimated)
No. of Female Employees: 260 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Salicylic acid, p-amino-, 2-(diethylamino)cyclohexylester, hydrochloride 78280-30-5
Salicylic acid, 4-amino-, 2-(diethylamino)ethyl ester 487-53-6
Salicylic acid, 4-amino-, 2-(diethylamino)ethylester, p-aminobenzoate (1:1) (salt) 487-53-6
Salicylic acid, 4-amino-, 2-(diethylamino)ethylester, 4-aminosalicylate (1:1) (salt) 15767-73-4
Salicylic acid, 4-amino-, 2-(diethylamino)ethylester, barbiturate (1:1) (salt) 15767-73-4
Salicylic acid, p-amino-, 2-(diethylamino)ethylester, hydrochloride 551-36-0
Salicylic acid, 4-amino-, 2-(diethylamino)ethylester, nicotine (1:1) (salt) 551-36-0
Salicylic acid, 4-amino-, 3-(diethylamino)propylester, hydrogen phosphate 102366-70-1
Ruthenium chloride 10049-08-8
Salicylic acid, p-amino-, 2-(dimethylamino)cyclohexylester, hydrochloride 78280-31-6
Salicylic acid, p-amino-, 2-(dimethylamino)ethylester, hydrochloride 78280-32-7
Salicylic acid, compd. with 2-aminoethanethiol (11) 78280-32-7
Salicylic acid, amino-, ethyl ester 6059-17-2
Salicylic acid, p-amino-, 1-ethyl-4-piperidyl ester,hydrochloride 78308-36-8
Salicylic acid, 4-amino-, hydrazide 6946-29-8
Salicylic acid, 5-amino-, hydrochloride 6291-36-7
Salicylic acid, amino-, 2-hydroxyethyl ester 14510-00-0
Salicylic acid, amino-, isopropyl ester 6018-21-9
Salicylic acid, amino-, methyl ester 4136-97-4
Ruthenium chloride, dihydrate 4136-97-4
Salicylic acid, 5-amino-, methyl ester 42753-75-3
Salicylic acid, p-amino-, 1-methyl-4-piperidyl ester,hydrochloride 78280-33-8
Salicylic acid, p-amino-, 2-(piperidinoethyl) ester,hydrochloride 102338-92-1
Salicylic acid, 4-amino-, 3-piperidinopropyl ester,monohydrochloride 102338-93-2
Salicylic acid, 4-amino-, sodium salt 133-10-8
Salicylic acid, 4-amino-, p-tolyl ester 56356-15-1
Salicylic acid compd. with antipyrine (11) 520-07-0
Salicylic acid, 4-(2-(benzylamino)acetamido)-, ethylester, monohydrochloride 14102-41-1
Salicylic acid, 4-(2-(benzylamino)acetamido)-, methylester, monohydrochloride 14102-30-8
Salicylic acid, 4-(3-(benzylamino)propionamido)-,ethyl ester, monohydrochloride 14025-36-6
Ruthenium chloride hydroxide 16845-29-7
Salicylic acid, 4-(3-(benzylamino)propionamido)-,methyl ester, monohydrochloride 14034-35-6
Salicylic acid, benzyl ester 118-58-1
Salicylic acid, (bis(8-hydroxyquinolyl)amino)- 55720-09-7
Salicylic acid, bismuth(3+) salt (31) 7460-14-2
Salicylic acid, 5-bromo- 89-55-4
Salicylic acid, 5-bromo-, acetate 1503-53-3
Salicylic acid, 5-((p-bromophenyl)azo)- 21461-15-4
Salicylic acid, p-butylamino-,2-(diethylamino)cyclohexyl ester, hydrochloride 78280-34-9
Salicylic acid, p-(butylamino)-,2-(diethylamino)ethyl ester 78280-34-9
Salicylic acid, 4-butylamino-, 2-(diethylamino)ethylester, dihydrochloride 102338-94-3
Ruthenium(2+), chloropentaammine-, dichloride,(OC-6-22)- 18532-87-1
Salicylic acid, p-butylamino-, 2-(diethylamino)ethylester, hydrochloride 528-97-2
Salicylic acid, p-butylamino-,2-(dimethylamino)cyclohexyl ester, hydrochloride 78280-35-0
Salicylic acid, p-(butylamino)-,2-(dimethylamino)ethyl ester 490-98-2
Salicylic acid, p-butylamino-, 2-(dimethylamino)ethylester, hydrochloride 17284-75-2
Salicylic acid, p-butylamino-, 1-ethyl-4-piperidylester, hydrochloride 78308-37-9
Salicylic acid, p-butylamino-, 1-methyl-4-piperidylester, hydrochloride 78280-36-1
Salicylic acid, 4-butylamino-, 3-piperidinopropylester, dihydrochloride 102338-95-4
Salicylic acid, butyl ester 2052-14-4

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