*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : VO1700000
CHEMICAL NAME : Salicylic acid, 4-amino-, sodium salt
CAS REGISTRY NUMBER : 133-10-8
LAST UPDATED : 199701
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C7-H6-N-O3.Na
MOLECULAR WEIGHT : 175.13
WISWESSER LINE NOTATION : ZR CQ DVO &-NA-
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* p-Aminosalicylate sodium
* p-Aminosalicylic acid sodium salt
* Bactylan
* Benzoic acid, 4-amino-2-hydroxy-, monosodium salt
* Lepasen
* Monosodium T4-amino-2-hydroxybenzoate
* Natri-pas
* Nippas
* Pamisyl sodium
* Pasade
* Pasalon-rakeet
* PAS-Na
* Pasnal
* Passodico
* Salvis
* Sanipirol
* Sodiopas
* Sodium aminosalicylate
* Sodium p-aminosalicylate
* Sodium p-aminosalicylic acid
* Sodium PAS
* Tubersan
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZENBAX Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie,
Organische Chemie, Biochemie, Biophysik, Biologie. (Tuebingen, Fed. Rep.
Ger.) V.2B-27B, 1947-1972. For publisher information, see ZNCBDA.
Volume(issue)/page/year: 6B,183,1951
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4950 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZENBAX Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie,
Organische Chemie, Biochemie, Biophysik, Biologie. (Tuebingen, Fed. Rep.
Ger.) V.2B-27B, 1947-1972. For publisher information, see ZNCBDA.
Volume(issue)/page/year: 6B,183,1951
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 6900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZENBAX Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie,
Organische Chemie, Biochemie, Biophysik, Biologie. (Tuebingen, Fed. Rep.
Ger.) V.2B-27B, 1947-1972. For publisher information, see ZNCBDA.
Volume(issue)/page/year: 6B,183,1951
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3850 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland)
V.18-24, 1966-72. For publisher information, see PJPPAA.
Volume(issue)/page/year: 23,383,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
Volume(issue)/page/year: 146,466,1952
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3380 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book
Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For
publisher information, see ZYZAEU. Volume(issue)/page/year: 15(12),17,1980
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 247 mg/kg
SEX/DURATION : female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland)
V.18-24, 1966-72. For publisher information, see PJPPAA.
Volume(issue)/page/year: 23,383,1971
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 69300 ug/kg
SEX/DURATION : female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland)
V.18-24, 1966-72. For publisher information, see PJPPAA.
Volume(issue)/page/year: 23,383,1971
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE : 40 mg/kg
SEX/DURATION : female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland)
V.18-24, 1966-72. For publisher information, see PJPPAA.
Volume(issue)/page/year: 23,383,1971
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 1 mg/plate
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 19,939,1981
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 600 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 48,215,1977
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Ascites tumor
DOSE/DURATION : 6 pph
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211,
1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year:
335,69,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6099
No. of Facilities: 16 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 370 (estimated)
No. of Female Employees: 260 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Salicylic acid, p-amino-, 2-(diethylamino)cyclohexylester, hydrochloride
| 78280-30-5 |
Salicylic acid, 4-amino-, 2-(diethylamino)ethyl ester
| 487-53-6 |
Salicylic acid, 4-amino-, 2-(diethylamino)ethylester, p-aminobenzoate (1:1) (salt)
| 487-53-6 |
Salicylic acid, 4-amino-, 2-(diethylamino)ethylester, 4-aminosalicylate (1:1) (salt)
| 15767-73-4 |
Salicylic acid, 4-amino-, 2-(diethylamino)ethylester, barbiturate (1:1) (salt)
| 15767-73-4 |
Salicylic acid, p-amino-, 2-(diethylamino)ethylester, hydrochloride
| 551-36-0 |
Salicylic acid, 4-amino-, 2-(diethylamino)ethylester, nicotine (1:1) (salt)
| 551-36-0 |
Salicylic acid, 4-amino-, 3-(diethylamino)propylester, hydrogen phosphate
| 102366-70-1 |
Ruthenium chloride
| 10049-08-8 |
Salicylic acid, p-amino-, 2-(dimethylamino)cyclohexylester, hydrochloride
| 78280-31-6 |
Salicylic acid, p-amino-, 2-(dimethylamino)ethylester, hydrochloride
| 78280-32-7 |
Salicylic acid, compd. with 2-aminoethanethiol (11)
| 78280-32-7 |
Salicylic acid, amino-, ethyl ester
| 6059-17-2 |
Salicylic acid, p-amino-, 1-ethyl-4-piperidyl ester,hydrochloride
| 78308-36-8 |
Salicylic acid, 4-amino-, hydrazide
| 6946-29-8 |
Salicylic acid, 5-amino-, hydrochloride
| 6291-36-7 |
Salicylic acid, amino-, 2-hydroxyethyl ester
| 14510-00-0 |
Salicylic acid, amino-, isopropyl ester
| 6018-21-9 |
Salicylic acid, amino-, methyl ester
| 4136-97-4 |
Ruthenium chloride, dihydrate
| 4136-97-4 |
Salicylic acid, 5-amino-, methyl ester
| 42753-75-3 |
Salicylic acid, p-amino-, 1-methyl-4-piperidyl ester,hydrochloride
| 78280-33-8 |
Salicylic acid, p-amino-, 2-(piperidinoethyl) ester,hydrochloride
| 102338-92-1 |
Salicylic acid, 4-amino-, 3-piperidinopropyl ester,monohydrochloride
| 102338-93-2 |
Salicylic acid, 4-amino-, sodium salt
| 133-10-8 |
Salicylic acid, 4-amino-, p-tolyl ester
| 56356-15-1 |
Salicylic acid compd. with antipyrine (11)
| 520-07-0 |
Salicylic acid, 4-(2-(benzylamino)acetamido)-, ethylester, monohydrochloride
| 14102-41-1 |
Salicylic acid, 4-(2-(benzylamino)acetamido)-, methylester, monohydrochloride
| 14102-30-8 |
Salicylic acid, 4-(3-(benzylamino)propionamido)-,ethyl ester, monohydrochloride
| 14025-36-6 |
Ruthenium chloride hydroxide
| 16845-29-7 |
Salicylic acid, 4-(3-(benzylamino)propionamido)-,methyl ester, monohydrochloride
| 14034-35-6 |
Salicylic acid, benzyl ester
| 118-58-1 |
Salicylic acid, (bis(8-hydroxyquinolyl)amino)-
| 55720-09-7 |
Salicylic acid, bismuth(3+) salt (31)
| 7460-14-2 |
Salicylic acid, 5-bromo-
| 89-55-4 |
Salicylic acid, 5-bromo-, acetate
| 1503-53-3 |
Salicylic acid, 5-((p-bromophenyl)azo)-
| 21461-15-4 |
Salicylic acid, p-butylamino-,2-(diethylamino)cyclohexyl ester, hydrochloride
| 78280-34-9 |
Salicylic acid, p-(butylamino)-,2-(diethylamino)ethyl ester
| 78280-34-9 |
Salicylic acid, 4-butylamino-, 2-(diethylamino)ethylester, dihydrochloride
| 102338-94-3 |
Ruthenium(2+), chloropentaammine-, dichloride,(OC-6-22)-
| 18532-87-1 |
Salicylic acid, p-butylamino-, 2-(diethylamino)ethylester, hydrochloride
| 528-97-2 |
Salicylic acid, p-butylamino-,2-(dimethylamino)cyclohexyl ester, hydrochloride
| 78280-35-0 |
Salicylic acid, p-(butylamino)-,2-(dimethylamino)ethyl ester
| 490-98-2 |
Salicylic acid, p-butylamino-, 2-(dimethylamino)ethylester, hydrochloride
| 17284-75-2 |
Salicylic acid, p-butylamino-, 1-ethyl-4-piperidylester, hydrochloride
| 78308-37-9 |
Salicylic acid, p-butylamino-, 1-methyl-4-piperidylester, hydrochloride
| 78280-36-1 |
Salicylic acid, 4-butylamino-, 3-piperidinopropylester, dihydrochloride
| 102338-95-4 |
Salicylic acid, butyl ester
| 2052-14-4 |
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