*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : VO1400000
CHEMICAL NAME : Salicylic acid, 5-amino-
CAS REGISTRY NUMBER : 89-57-6
BEILSTEIN REFERENCE NO. : 2090421
REFERENCE : 4-14-00-02058 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C7-H7-N-O3
MOLECULAR WEIGHT : 153.15
WISWESSER LINE NOTATION : ZR DQ CVQ
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* 5-Amino-2-hydroxybenzoic acid
* 5-Aminosalicylic acid
* m-Aminosalicylic acid
* p-Aminosalicylsaeure
* 5-ASA
* Asacol
* Benzoic acid, 5-amino-2-hydroxy-
* Claversal
* Mesalamine
* Mesalazine
* Pentasa
* Salofalk
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 6857 mg/kg/17W-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Liver - jaundice, cholestatic
REFERENCE :
JOHEEC Journal of Hepathology. (Elsevier Science, 655 Avenue of the
Americas, New York, NY 10010) V.1- 1985- Volume(issue)/page/year:
26,425,1997
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 21800 mg/kg/39W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
Lungs, Thorax, or Respiration - respiratory depression
Blood - eosinophilia
REFERENCE :
AJGAAR American Journal of Gastroenterology. (American College of
Gastroenterology, Inc., 428 E. Preston St., Baltimore, MD 21202) V.21-
1954- Volume(issue)/page/year: 91,1039,1996
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 51 mg/kg/5D-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Skin and Appendages - dermatitis, other (after systemic exposure)
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 1,917,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 8 mg/kg
TOXIC EFFECTS :
Behavioral - headache
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 1,917,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 2057 mg/kg/17W-I
TOXIC EFFECTS :
Blood - agranulocytosis
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 341,1476,1993
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2800 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - food intake (animal)
Gastrointestinal - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570511
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Kidney, Ureter, Bladder - other changes in urine composition
Skin and Appendages - hair
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 47,505,1994
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZENBAX Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie,
Organische Chemie, Biochemie, Biophysik, Biologie. (Tuebingen, Fed. Rep.
Ger.) V.2B-27B, 1947-1972. For publisher information, see ZNCBDA.
Volume(issue)/page/year: 6B,183,1951
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 681 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International
Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
Volume(issue)/page/year: 64,247,1989
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 3 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - somnolence (general depressed activity)
Kidney, Ureter, Bladder - hematuria
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 47,509,1994
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570511
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 36400 mg/kg/13W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume increased
Kidney, Ureter, Bladder - changes in bladder weight
Blood - normocytic anemia
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 48,277,1994
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Salicylanilide, 3'-chloro-5-nitro-
| 6505-75-5 |
Salicylanilide, 4'-chloro-3-nitro-
| 6490-99-9 |
Ruta graveolens L., rootSUBSTANCE DEFINITION :From the Mediterranean region, cultivated in India and belonging to thefamily RutaceaeREFERENCE :JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. IrelandLtd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year:34,49,1991
| 6490-99-9 |
Salicylanilide, 4'-chloro-5-nitro-
| 6490-98-8 |
Salicylanilide, 2'-chloro-3-nitro-5'-trifluoromethyl-
| 33713-13-2 |
Salicylanilide, 4',5-dibromo-
| 87-12-7 |
Salicylanilide, 3,4'-dibromo-5-chlorothio-, acetate(ester)
| 23233-88-7 |
Salicylanilide, 4',5-dichloro-
| 1147-98-4 |
Salicylanilide, 2',5-dichloro-4'-nitro-
| 50-65-7 |
Salicylanilide, 3',4'-dichloro-3-nitro-
| 29378-25-4 |
Salicylanilide, 2',5-dichloro-4'-nitro-, compd. with2-aminoethanol (1:1)
| 1420-04-8 |
Salicylanilide, 3,4'-dinitro-
| 39832-34-3 |
Salicylanilide, 4'-fluoro-3-nitro-
| 4043-45-2 |
Rufomycin A
| 37248-35-4 |
Rutamycin
| 1404-59-7 |
Salicylanilide, 4'-hydroxy-
| 526-18-1 |
Salicylanilide, 4'-iodo-3-nitro-
| 10515-48-7 |
Salicylanilide, 3,3',4',5-tetrachloro-
| 1154-59-2 |
Salicylanilide, tribromo-
| 1322-38-9 |
Salicylanilide, 3,4',5-tribromo-
| 87-10-5 |
Salicylanilide, 3,4',5-tribromo- mixed with3,5-dibromosalicylanilide
| 8015-34-7 |
Salicylanilide, 3,4',5'-triiodo-
| 14437-45-7 |
Salicylic acid
| 69-72-7 |
Salicylic acid, 4-acetamido-
| 50-86-2 |
Salicylic acid, 4-acetamido-, acetate (ester)
| 50-86-2 |
Ruthenate(2+), nitrosylpentachloro-, diammonium,(OC-6-21)-
| 13820-58-1 |
Salicylic acid, 4-acetamido-, compd. with7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline (2:1)
| 58-77-5 |
Salicylic acid, 5-acetamido-, compd. withhexamethylenetetramine
| 58-77-5 |
Salicylic acid, acetate
| 50-78-2 |
Salicylic acid, acetate, anhydride
| 1466-82-6 |
Salicylic acid, acetate, calcium salt
| 69-46-5 |
Salicylic acid, acetate, ester with4'-hydroxyacetanilide
| 5003-48-5 |
Salicylic acid, acetate, ester with methanediol
| 5003-48-5 |
Salicylic acid, acetate mixed with ethylalpha-(p-chlorophenoxy)isobutyrate (1:1)
| 5003-48-5 |
Salicylic acid, acetate, magnesium salt
| 132-49-0 |
Salicylic acid, acetate, 7-nitro-8-quinolyl ester
| 29007-29-2 |
Ruthenate(2+), nitrosylpentachloro-, dipotassiumhydrate
| 14854-54-7 |
Salicylic acid, acetate, sodium salt
| 493-53-8 |
Salicylic acid, acetyl-, and7-methoxy-alpha,10-dimethylphenothiazine-2-aceticacid
| 72360-92-0 |
Salicylic acid, 3-allyl-, methyl ester
| 31456-98-1 |
Salicylic acid, 4-amino-
| 65-49-6 |
Salicylic acid, 5-amino-
| 89-57-6 |
Salicylic acid, 4-amino-, acetate
| 102338-89-6 |
Salicylic acid, 4-amino-, acetate, sodium salt
| 102338-90-9 |
Salicylic acid, (o-aminobenzoyl)hydrazide
| 28864-31-5 |
Salicylic acid, (p-aminobenzoyl)-, methyl ester,hydrochloride
| 28864-31-5 |
Salicylic acid, amino-, sec-butyl ester
| 102338-91-0 |
Ruthenium(3+), (adenosine)pentaammine-, tribromide
| 67848-03-7 |
Salicylic acid, p-amino-, calcium salt (21)
| 133-15-3 |
Salicylic acid, amino-, 2-chloroethyl ester
| 16987-14-7 |
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