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MSDS  : Succinic acid, mercapto-, diethyl ester, S-ester with O,O-dimethylphosphorothioate
CAS  : 1634-78-2
SYNONYMS  : * Butanedioic acid, ((dimethoxyphosphinyl)thio)-, diethyl ester * Carbethoxy malaoxon * S-(1,2-Diethoxycarbonyl)ethyl O,O-dimethyl phosphorothioate * O,O-Dimethyl-S-1,2-bis(ethoxycarbonyl)ethyl phosphorothioate * O,O-Dimethyl-S-(1,2-dicarbethoxy)ethyl phosphorothioate * Liromat * Malaoxon * Malaoxone * Malathion-O-analog * NCI-C08628 * Oxycarbophos * Phosphorothioic acid, O,O-dimethyl ester, S-ester with 1,2-bis(ethoxycarbonyl)ethanethiol
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : WM8410000
CHEMICAL NAME : Succinic acid, mercapto-, diethyl ester, S-ester with
O,O-dimethylphosphorothioate
CAS REGISTRY NUMBER : 1634-78-2
LAST UPDATED : 199806
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C10-H19-O7-P-S
MOLECULAR WEIGHT : 314.32
WISWESSER LINE NOTATION : 2OV1YVO2&SPO&O1&O1
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Butanedioic acid, ((dimethoxyphosphinyl)thio)-, diethyl ester
* Carbethoxy malaoxon
* S-(1,2-Diethoxycarbonyl)ethyl O,O-dimethyl phosphorothioate
* O,O-Dimethyl-S-1,2-bis(ethoxycarbonyl)ethyl phosphorothioate
* O,O-Dimethyl-S-(1,2-dicarbethoxy)ethyl phosphorothioate
* Liromat
* Malaoxon
* Malaoxone
* Malathion-O-analog
* NCI-C08628
* Oxycarbophos
* Phosphorothioic acid, O,O-dimethyl ester, S-ester with
1,2-bis(ethoxycarbonyl)ethanethiol

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 158 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,408,1966

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 17500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CJPPA3 Canadian Journal of Physiology and Pharmacology. (National Research
Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
Canada) V.42- 1964- Volume(issue)/page/year: 45,621,1967

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 215 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.1- 1953- Volume(issue)/page/year: 28,599,1980

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71.
Discontinued. Volume(issue)/page/year: 3,28,1964

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 119 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534701

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 8200 ug/kg
SEX/DURATION : female 18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road,
Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
Volume(issue)/page/year: 12,469,1993

** MUTATION DATA **

TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 5 ppm
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
23,208,1994

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 132 mg/L
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
10,21,1990

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 124 mg/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
236,933,1987

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 100 umol/L
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 8,939,1981

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat

NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-135,79


*** END OF RECORD ***
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NAMECAS
Succinic acid, ester withN-(7,13-dihydroxy-1,4,10,19-tetramethyl-17,18-dioxo-16-oxabicyclo(13.2.2)nonadeca-3,5,9,11-tetraen-2-yl)pyruvamide(2:1), (-)- 28477-81-8
Succinic acid, (4-ethoxy-1-naphthylcarbonylmethyl)ester 60634-59-5
Succinic acid, (1-ethoxy-3-phenoxy)isopropyl ester,sodium salt 63979-79-3
Succinic acid, ethyl ester, ester withD-threo-(-)-2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide 63979-79-3
Succinic acid,1-(N-2-ethylhexylcarbamoyl)-2-methylethyl ester,calcium salt 63979-79-3
Succinic acid, 1-ethyl-1-methyl-2-propynyl ester,sodium salt 102367-21-5
Succinic acid, (2-(5-ethyl-2-nitroimidazolyl)ethyl)ester 23571-47-3
Succinic acid, alpha-ethyl-p-phenylbenzyl ester 50673-55-7
Succinic acid, 2-ethyl-2-phenyl-,1-(2-(diethylamino)ethyl) 4-ethyl ester 50673-55-7
Succinic acid, 2-ethyl-2-phenyl-,4-(2-diethylaminoethyl) 1-ethyl ester 94755-54-1
Strychnos staudtii Gilg., bark extract 94755-54-1
Succinic acid, 1-ethyl-2-propynyl ester, sodium salt 102367-22-6
Succinic acid, formyl-, diethyl ester, diethylacetal 70145-29-8
Succinic acid,2-(m-(1,3,5-hexatrienyl)phenyl)hydrazide 25375-16-0
Succinic acid, 2-hydroxyethyl ester, ester withbenzylcarbamic acid, monosodium salt 25375-16-0
Succinic acid, 2-hydroxyethyl ester, ester with(beta-methylphenethyl)carbamic acid, monosodium salt 25375-16-0
Succinic acid, 2-hydroxyethyl ester, ester withphenethylcarbamic acid, monosodium salt 25375-16-0
Succinic acid,2-(hydroxymethoxy)-2-((p-sulfamoylphenylcarbamoyl)methyl)-, gamma-lactone 109473-28-1
Succinic acid, isobutyl ester, ester withD-threo-(-)-2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide 109473-28-1
Succinic acid, isopropyl ester, ester withD-threo-(-)-2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide 109473-28-1
Succinic acid, mercapto- 70-49-5
Strychnos dolichothyrsa Gilg. ex Onochie et Hepper,extract 70-49-5
Strychnos ternata Gilg ex Lecuwenberg, extract 70-49-5
Succinic acid, mercapto-, 4-allyl1-(2-mercaptopropyl) ester, S,S-diester with O,O-dimethylphosphorodithioate 32358-07-9
Succinic acid, mercapto-, diethyl ester, S-ester withO,O-dimethylphosphorodithioate 121-75-5
Succinic acid, mercapto-, diethyl ester, S-ester withO,O-dimethylphosphorothioate 1634-78-2
Succinic acid, mercapto-, diethyl ester, S-ester withO,S-dimethyl phosphorodithioate 3344-12-5
Succinic acid, mercapto-, diethyl ester, propylmethylphosphonotrithioate 17581-48-5
Succinic acid, mercapto-, diisopropyl ester 63979-80-6
Succinic acid, mercapto-, dilauryl ester 63979-81-7
Succinic acid, mercapto-, dimethyl ester 1795-56-8
Succinic acid, (2-mercaptoethylamino)-, diethylester, hydrochloride 73926-96-2
Succinic acid, 2-((2-mercaptoethyl)thio)-, diethylester, S-ester with O,O-diethyl phosphoro dithioate 73926-96-2
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Succinic acid, 2-((2-mercaptoethyl)thio)-,diisopropyl ester, S-ester with O,O-diethylphosphorodithioate 73926-96-2
Succinic acid, 2-((2-mercaptoethyl)thio)-, dimethylester, S-ester with O,O-diethyl phosphoro dithioate 73926-96-2
Succinic acid, 2-((2-mercaptoethyl)thio)-, dimethylester, S-ester with diethyl phosphoro thioate 73926-96-2
Succinic acid, 2-((mercaptomethyl)thio)-, diethylester, S-ester with O,O-diethyl phosphoro dithioate 73926-96-2
Succinic acid, 2-((mercaptomethyl)thio)-, dimethylester, S-ester with O,O-diethyl phosphoro dithioate 73926-96-2
Succinic acid, 2-((mercaptomethyl)thio)-, dimethylester, S-ester with diethyl phosphoro thioate 73926-96-2
Succinic acid, mercapto-, thioantimonate (III),dilithium salt, nonahydrate 6169-12-6
Succinic acid, methylene-, bis(p-bromophenacyl) ester 73926-97-3
Succinic acid, methylene-, ester with lactic acidallyl ester (1:1) 63690-10-8
Succinic acid, 1-methyl-2-propynyl ester 102367-23-7
Strychnos tricalysioides Hutch. et M.B. Moss, extract 102367-23-7
Succinic acid, mono(1-(1-adamantyl)ethyl) ester 18484-32-7
Succinic acid, mono(1-(1-adamantyl)propyl) ester 15037-74-8
Succinic acid,mono(alpha-2-benzofuranyl-p-bromobenzyl) ester 3611-63-0
Succinic acid,mono(alpha-2-benzofuranyl-p-chlorobenzyl) ester 3607-35-0
Succinic acid,mono(alpha-2-benzofuranyl-p-iodobenzyl) ester 3611-60-7

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