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MSDS  : Sulfanilamide, N(sup 1)-2-pyrimidinyl-, monosilver(1+) salt
CAS  : 22199-08-2
SYNONYMS  : * 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide silver salt * Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, monosilver(1+) salt * Dermazine * Flamazine * Geben * Silvadene * Silver sulfadiazine * Silver sulphadiazine * Sulfadiazine silver * Sulfadiazine silver salt
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : WP1950000
CHEMICAL NAME : Sulfanilamide, N(sup 1)-2-pyrimidinyl-,
monosilver(1+) salt
CAS REGISTRY NUMBER : 22199-08-2
LAST UPDATED : 199712
DATA ITEMS CITED : 34
MOLECULAR FORMULA : C10-H10-N4-O2-S.Ag
MOLECULAR WEIGHT : 358.17
WISWESSER LINE NOTATION : T6N CNJ BMSWR DZ &-AG-
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide silver salt
* Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, monosilver(1+) salt
* Dermazine
* Flamazine
* Geben
* Silvadene
* Silver sulfadiazine
* Silver sulphadiazine
* Sulfadiazine silver
* Sulfadiazine silver salt

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Human - man
DOSE/DURATION : 536 mg/kg/21W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 340,126,1992

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 13,637,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 126 mg/kg
TOXIC EFFECTS :
Liver - other changes
Blood - changes in spleen
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 14,2850,1980

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >10 gm/kg
TOXIC EFFECTS :
Liver - other changes
Blood - changes in spleen
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 14,2850,1980

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #4535078

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >10 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 14,2850,1980

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 550 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #4020150

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >10 gm/kg
TOXIC EFFECTS :
Liver - other changes
Blood - changes in spleen
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 14,2850,1980

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 240 mg/kg/30D-C
TOXIC EFFECTS :
Endocrine - other changes
Blood - changes in spleen
Biochemical - Effect on specific coenzyme - not otherwise specified
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 14,2856,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1456 mg/kg/13W-C
TOXIC EFFECTS :
Liver - other changes
Blood - changes in spleen
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 14,2913,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 728 mg/kg/26W-C
TOXIC EFFECTS :
Liver - other changes
Blood - changes in spleen
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 14,2913,1980

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 44 gm/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 8,3637,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 11 gm/kg
SEX/DURATION : male 70 day(s) pre-mating
female 2 week(s) pre-mating - 7 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 8,3637,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 11 gm/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 8,3637,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE : 26 gm/kg
SEX/DURATION : female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 8,3637,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE : 6500 mg/kg
SEX/DURATION : female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 8,3637,1980

** MUTATION DATA **

TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 5 mg/L
REFERENCE :
AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for
Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972-
Volume(issue)/page/year: 2,367,1972

TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 4 mg/L
REFERENCE :
PAMIAD Pathologica et Microbiologia. (Basel, Switzerland) V.23-43,
1960-75. For publisher information, see ECEBDI. Volume(issue)/page/year:
39,434,1973

TYPE OF TEST : DNA inhibition
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 2500 ug/L
REFERENCE :
AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for
Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972-
Volume(issue)/page/year: 2,367,1972

*** REVIEWS ***

ACGIH TLV-TWA 0.01 mg(Ag)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

*** U.S. STANDARDS AND REGULATIONS ***

MSHA STANDARD-air:TWA 0.01 mg(Ag)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,231,1971

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-ARAB Republic of Egypt:TWA 0.01 mg(Ag)/m3 JAN 1993

OEL-AUSTRALIA:TWA 0.01 mg(Ag)/m3 JAN 1993

OEL-BELGIUM:TWA 0.01 mg(Ag)/m3 JAN 1993

OEL-DENMARK:TWA 0.01 mg(Ag)/m3 JAN 1993

OEL-FINLAND:TWA 0.01 mg(Ag)/m3;STEL 0.03 mg(Ag)/m3;Skin JAN 1993

OEL-THE NETHERLANDS:TWA 0.01 mg(Ag)/m3 JAN 1993

OEL-THE PHILIPPINES:TWA 0.01 mg(Ag)/m3 JAN 1993

OEL-SWITZERLAND:TWA 0.01 mg(Ag)/m3 JAN 1993

OEL-UNITED KINGDOM:TWA 0.01 mg(Ag)/m3 JAN 1993

OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5603
No. of Facilities: 944 (estimated)
No. of Industries: 9
No. of Occupations: 10
No. of Employees: 87352 (estimated)
No. of Female Employees: 71312 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Sulfanilamide, N(sup 1)-methyl- 1709-52-0
Sulfanilamide, N'-(5-methyl-3-isoxazolyl)- 723-46-6
Sulfanilamide, N(sup1)-(2-methyl-6-propoxy-4-pirimidinyl)-, sodium salt 723-46-6
Sulfanilamide, N(sup1)-(6-methyl-2-propyl-4-pyrimidinyl)-, sodium salt 723-46-6
Sulfanilamide, N(sup 1)-(4-methyl-2-pyrimidinyl)- 127-79-7
Sulfanilamide, N(sup 1)-(5-methyl-2-pyrimidinyl)- 599-88-2
Sulfanilamide, N(sup 1)-(4-methyl-2-pyrimidinyl)-,monosodium salt 127-58-2
Sulfanilamide, N(sup1)-(4-methyl-2-pyrimidinyl)-N(sup 1)-(2-(5-tetrazolyl)ethyl)- 69518-43-0
Sulfanilamide, N(sup1)-(5-methyl-1,3,4-thiadiazol-2-yl)- 144-82-1
Sulfanilamide, N(sup1)-(5-methyl-1,3,4-thiadiazol-2-yl)-, monosodium salt 58944-03-9
Styrene, alpha-nitro- 5468-44-0
Sulfanilamide, N(sup 1)-(4-methyl-2-thiazolyl)- 515-59-3
Sulfanilamide, N(sup 1)-(4-methyl-2-thiazolyl)-,sodium salt 58944-02-8
Sulfanilamide, N(sup1)-(4-methyl-6-(trifluoromethyl)-2-pyrimidinyl)- 6190-24-5
Sulfanilamide monohydrochloride 6101-31-1
Sulfanilamide, monosodium salt 10103-15-8
Sulfanilamide, N(sup 1)-(2-morpholinoethyl)- 1784-16-3
Sulfanilamide, N(sup 1)-(1-phenylpyrazol-5-yl)-,sodium salt 1784-16-3
Sulfanilamide, N(sup 1)-(4-phenyl-2-thiazolyl)-,sodium salt 63979-88-4
Sulfanilamide, N(sup 1)-(2-propyl-4-pyrimidinyl)-,sodium salt 63979-88-4
Sulfanilamide, N(sup 1)-(2-pyrazinyl)-, monosodiumsalt 63979-88-4
Styrene, beta-nitro- 102-96-5
Sulfanilamide, N(sup 1)-2-pyridyl-, 1-oxide 19250-24-9
Sulfanilamide, N(sup 1)-(2-pyridyl)-N(sup1)-(2-(5-tetrazolyl)ethyl)- 69518-41-8
Sulfanilamide, N(sup 1)-2-pyrimidinyl- 68-35-9
Sulfanilamide, N(sup 1)-2-pyrimidinyl-,monosilver(1+) salt 22199-08-2
Sulfanilamide, N(sup 1)-2-pyrimidinyl-, monosodiumsalt 547-32-0
Sulfanilamide, N(sup 1)-(2-pyrimidinyl)-N(sup1)-(2-(5-tetrazolyl)ethyl)- 69518-42-9
Sulfanilamide, N(sup 1)-2-quinoxalinyl- 59-40-5
Sulfanilamide, N(sup 1)-(2-(5-tetrazolyl)ethyl)-N(sup1)-(2-thiazolyl)- 69518-36-1
Sulfanilamide, N(sup 1)-2-thiazolyl- 72-14-0
Sulfanilamide, N(sup 1)-2-thiazolyl-, monosodium salt 144-74-1
Styrene, beta-nitro-, (E)- 5153-67-3
Sulfanilamide, N(sup 1)-2-thiazolyl-, 3-oxide 19250-30-7
Sulfanilamide, N(sup 1)-(2-thienyl)-, monosodium salt 102395-93-7
Sulfanilamide, N(sup 4),N(sup 4')-thiodi- 69226-52-4
Sulfanilanilide, N(sup 1)-((trichloromethyl)thio)- 69226-52-4
Sulfanilanilide, 4'-(9-acridinylamino)- 57164-91-7
Sulfanilanilide, 4'-(dimethylsulfamoyl)- 515-67-3
Sulfanilanilide, 4'-fluoro- 1494-85-5
p-Sulfanilanisidide, 2'-amino- 1494-85-5
p-Sulfanilanisidide, 2'-amino-, sodium salt 1494-85-5
Sulfanilic acid 121-57-3
Styrene, p-nitro- 100-13-0
Sulfanilic acid, N-acetyl-, 2-pentyl ester 23531-31-9
Sulfanilic acid, N-(amidinoamidino)- 6405-80-7
Sulfanilic acid, N-(amidinoamidino)-, hydrochloride 6405-80-7
Sulfanilic acid, N-(amidinocarbamoyl)-, hydrochloride 73927-06-7
Sulfanilic acid, compd. with 2-aminoethanol (11) 15730-83-3
Sulfanilic acid, 2-(diethylamino)ethyl ester 15730-83-3

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