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MSDS  : Sulfoxylic acid, mono(((5-((3-amino-4-hydroxyphenyl)diarsenyl)-2-hydro xyphenyl)amino) methyl) ester, monosodium salt
CAS  : 457-60-3
SYNONYMS  : * ((5-(3-Amino-4-hydroxyphenyl)arseno)-2-hydroxyanilino)methanol sulfoxylate sodium * Arsevan * Arsphenamine methylenesulfoxylic acid sodium salt * Collunovar * Collunover * 3,3'-Diamino-4,4'-dihydroxyarsenobenzenemethylenesulfoxylate sodium * Miarsenol * N.A.B. * Neoarsfenamin * Neoarsoluin * Neoarsphenamine * Neo-I.C.I. * Neosalvarsan * Novarsenobenzol * Novarsenobillon * Novarsenol
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : WS3680000
CHEMICAL NAME : Sulfoxylic acid,
mono(((5-((3-amino-4-hydroxyphenyl)diarsenyl)-2-hydro
xyphenyl)amino) methyl) ester, monosodium salt
CAS REGISTRY NUMBER : 457-60-3
LAST UPDATED : 199703
DATA ITEMS CITED : 31
MOLECULAR FORMULA : C13-H13-As2-N2-O4-S.Na
MOLECULAR WEIGHT : 466.17
WISWESSER LINE NOTATION : ZR BQ E-AS-U-AS-R DQ CM1OSO &-NA-
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* ((5-(3-Amino-4-hydroxyphenyl)arseno)-2-hydroxyanilino)methanol
sulfoxylate sodium
* Arsevan
* Arsphenamine methylenesulfoxylic acid sodium salt
* Collunovar
* Collunover
* 3,3'-Diamino-4,4'-dihydroxyarsenobenzenemethylenesulfoxylate sodium
* Miarsenol
* N.A.B.
* Neoarsfenamin
* Neoarsoluin
* Neoarsphenamine
* Neo-I.C.I.
* Neosalvarsan
* Novarsenobenzol
* Novarsenobillon
* Novarsenol

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 9,354,1917

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 9,354,1917

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 318 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 73,12,1941

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 9,354,1917

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 9,354,1917

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 2,28,1947

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 9,354,1917

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 9,354,1917

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 9,354,1917

*** U.S. STANDARDS AND REGULATIONS ***

MSHA STANDARD-air:TWA 0.5 mg(As)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,16,1971

OSHA PEL (Gen Indu):8H TWA 0.5 mg(As)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994

OSHA PEL (Construc):8H TWA 0.5 mg(As)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 0.5 mg(As)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993

OSHA PEL (Fed Cont):8H TWA 0.5 mg(As)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-ARAB Republic of Egypt:TWA 0.2 mg(As)/m3 JAN 1993

OEL-AUSTRALIA:TWA 0.05 mg(As)/m3;Carcinogen JAN 1993

OEL-BELGIUM:TWA 0.2 mg(As)/m3 JAN 1993

OEL-DENMARK:TWA 0.05 mg(As)/m3 JAN 1993

OEL-FINLAND;Carcinogen JAN 1993

OEL-FRANCE:TWA 0.2 mg(As)/m3 JAN 1993

OEL-HUNGARY:STEL 0.5 mg(As)/m3;Carcinogen JAN 1993

OEL-INDIA:TWA 0.2 mg(As)/m3 JAN 1993

OEL-THE PHILIPPINES:TWA 0.5 mg(As)/m3 JAN 1993

OEL-POLAND:TWA 0.3 mg(As)/m3 JAN 1993

OEL-SWEDEN:TWA 0.03 mg(As)/m3;Carcinogen JAN 1993

OEL-SWITZERLAND:TWA 0.1 mg(As)/m3;Carcinogen JAN 1993

OEL-THAILAND:TWA 0.5 mg(As)/m3 JAN 1993

OEL-TURKEY:TWA 0.5 mg(As)/m3 JAN 1993

OEL-UNITED KINGDOM:TWA 0.2 mg(As)/m3 JAN 1993

OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV


*** END OF RECORD ***
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