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MSDS  : 1,3,4-Thiadiazole, 2,2'-(methylenediimino)bis-
CAS  : 26907-37-9
SYNONYMS  : * Bis-A-tda * N,N'-Bis(1,3,4-thiadazol-2-yl)methane diamine * Di-Ku-shuang * N,N'-Methylenebis(2-amino-1,3,4-thiadiazole) * NSC-143019 * TK-5477
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : XI4100000
CHEMICAL NAME : 1,3,4-Thiadiazole, 2,2'-(methylenediimino)bis-
CAS REGISTRY NUMBER : 26907-37-9
BEILSTEIN REFERENCE NO. : 0993888
LAST UPDATED : 199612
DATA ITEMS CITED : 23
MOLECULAR FORMULA : C5-H6-N6-S2
MOLECULAR WEIGHT : 214.29
WISWESSER LINE NOTATION : T5NN DSJ CM1M- CT5NN DSJ
COMPOUND DESCRIPTOR : Agricultural Chemical
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Bis-A-tda
* N,N'-Bis(1,3,4-thiadazol-2-yl)methane diamine
* Di-Ku-shuang
* N,N'-Methylenebis(2-amino-1,3,4-thiadiazole)
* NSC-143019
* TK-5477

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 260 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Gastrointestinal - changes in structure or function of salivary glands
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
CIYPDA Sichuan Yixueyuan Xuebao. Acta Akademiae Medicinae Sichuan.
(Beijing, Peop. Rep. China) V.1-16, 1970-85. For publisher information, see
HYDXET. Volume(issue)/page/year: 12,345,1981

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 82 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
Skin and Appendages - hair
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
Japan) V.29- 1970- Volume(issue)/page/year: 35,68,1976

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 125 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
Skin and Appendages - hair
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
Japan) V.29- 1970- Volume(issue)/page/year: 35,68,1976

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2250 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Gastrointestinal - changes in structure or function of salivary glands
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
CIYPDA Sichuan Yixueyuan Xuebao. Acta Akademiae Medicinae Sichuan.
(Beijing, Peop. Rep. China) V.1-16, 1970-85. For publisher information, see
HYDXET. Volume(issue)/page/year: 12,345,1981

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 430 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
Skin and Appendages - hair
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
Japan) V.29- 1970- Volume(issue)/page/year: 35,68,1976

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 145 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Gastrointestinal - changes in structure or function of salivary glands
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
CIYPDA Sichuan Yixueyuan Xuebao. Acta Akademiae Medicinae Sichuan.
(Beijing, Peop. Rep. China) V.1-16, 1970-85. For publisher information, see
HYDXET. Volume(issue)/page/year: 12,345,1981

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 125 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
Skin and Appendages - hair
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
Japan) V.29- 1970- Volume(issue)/page/year: 35,68,1976

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Gastrointestinal - changes in structure or function of salivary glands
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
CIYPDA Sichuan Yixueyuan Xuebao. Acta Akademiae Medicinae Sichuan.
(Beijing, Peop. Rep. China) V.1-16, 1970-85. For publisher information, see
HYDXET. Volume(issue)/page/year: 12,345,1981

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
Skin and Appendages - hair
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
Japan) V.29- 1970- Volume(issue)/page/year: 35,68,1976

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Gastrointestinal - changes in structure or function of salivary glands
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
CIYPDA Sichuan Yixueyuan Xuebao. Acta Akademiae Medicinae Sichuan.
(Beijing, Peop. Rep. China) V.1-16, 1970-85. For publisher information, see
HYDXET. Volume(issue)/page/year: 12,345,1981

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Gastrointestinal - changes in structure or function of salivary glands
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
CIYPDA Sichuan Yixueyuan Xuebao. Acta Akademiae Medicinae Sichuan.
(Beijing, Peop. Rep. China) V.1-16, 1970-85. For publisher information, see
HYDXET. Volume(issue)/page/year: 12,345,1981

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 560 mg/kg/4W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Liver - hepatitis (hepatocellular necrosis), zonal
Endocrine - other changes
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
Japan) V.29- 1970- Volume(issue)/page/year: 34,480,1975

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 140 mg/kg/4W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
Blood - normocytic anemia
Endocrine - other changes
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
Japan) V.29- 1970- Volume(issue)/page/year: 34,480,1975

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 5 mg/kg
SEX/DURATION : female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
CPHPA5 Jiepou Xuebao. Journal of Anatomy. (China International Book
Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-9, 1953-66; V.10-
1979- Volume(issue)/page/year: 12,212,1981

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1 mg/kg
SEX/DURATION : female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
SURR** Szechuan University Research Report, Natural Science. (Szechuan
University, Szechuan, Peop. Rep. China) No.2/3- 1978-
Volume(issue)/page/year: 2/3,105,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1 mg/kg
SEX/DURATION : female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
SURR** Szechuan University Research Report, Natural Science. (Szechuan
University, Szechuan, Peop. Rep. China) No.2/3- 1978-
Volume(issue)/page/year: 2/3,105,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 5 mg/kg
SEX/DURATION : female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
SURR** Szechuan University Research Report, Natural Science. (Szechuan
University, Szechuan, Peop. Rep. China) No.2/3- 1978-
Volume(issue)/page/year: 2/3,105,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 5 mg/kg
SEX/DURATION : female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
SURR** Szechuan University Research Report, Natural Science. (Szechuan
University, Szechuan, Peop. Rep. China) No.2/3- 1978-
Volume(issue)/page/year: 2/3,105,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 5 mg/kg
SEX/DURATION : female 6-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal
of Pharmacology. (China International Book Trading Corp., POB 2820,
Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year:
5,195,1984

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 5 mg/kg
SEX/DURATION : female 6-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal
of Pharmacology. (China International Book Trading Corp., POB 2820,
Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year:
5,195,1984

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 45 mg/kg
SEX/DURATION : female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal.
(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year:
16,654,1981

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 60 mg/kg
SEX/DURATION : female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal.
(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year:
16,654,1981

** MUTATION DATA **

TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 200 mg/kg
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 43,359,1987

*** END OF RECORD ***
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NAMECAS
1,2,5-Thiadiazole-3,4-diamine,N-((2-(((2-((dimethylamino)methyl)-1H-benzimidazol-5-yl) methyl)thio)ethyl)-, 1-oxide 92715-97-4
2-Thenylamine, alpha-(m-fluorobenzyl)-, hydrochloride 80154-78-5
1,2,5-Thiadiazole-3,4-diamine,N-((2-(((2-((dimethylamino)methyl)-1H-benzimidazol-5-yl) methyl)thio)ethyl)-, 1,1-dioxide 92715-98-5
1,2,5-Thiadiazole-3,4-diamine,N-(4-((4-((dimethylamino)methyl)-2-pyridinyl)oxy)-2-butenyl)-, 1-oxide, (Z)- 103922-41-4
1,2,5-Thiadiazole-3,4-diamine,N-(4-((4-((dimethylamino)methyl)-2-pyridinyl)oxy)-2-butenyl)- N'-methyl-, 1-oxide, (Z)- 103922-42-5
1,2,5-Thiadiazole-3,4-diamine,N-(4-((4-(1-piperidinylmethyl)-2-pyridinyl)oxy)-2-butenyl)-, 1-oxide, (E)- 103922-40-3
1,3,4-Thiadiazole, 2,5-diamino- 2937-81-7
1,2,4-Thiadiazole, 3,5-diamino-, p-toluenesulfonate 5380-27-8
1,3,4-Thiadiazole,2,3-dihydro-2-(oxiranylmethoxy)-2,3,5-triphenyl- 160455-73-2
1,2,4-Thiadiazole-3,5(2H,4H)-diimine, N(sup 3),N(sup5)-bis(cyclohexyl)-2,4-dimethyl- 118489-27-3
1,2,4-Thiadiazole-3,5(2H,4H)-diimine, N(sup 3),N(sup5)-bis(3-methylphenyl)-2,4-dimethyl- 118489-23-9
1,2,4-Thiadiazole-3,5(2H,4H)-diimine, N(sup 3),N(sup5)-bis(4-methylphenyl)-2,4-dimethyl- 64958-77-6
2-Thenylamine, alpha-(p-fluorobenzyl)-, hydrochloride 80154-80-9
1,3,4-Thiadiazole, 2-(dimethylamino)-, hydrobromide 63503-45-7
1,3,4-Thiadiazole, 2-(dimethylamino)-5-methyl-,hydrochloride 63503-47-9
1,3,4-Thiadiazole, 2-(dimethylamino)-5-(methylthio)- 51412-78-3
1,3,4-Thiadiazole,2-(N,N'-dimethylureido)-5-trifluoromethyl- 25366-23-8
1,2,4-Thiadiazole, 3,5-diphenyl- 4115-15-5
1,3,4-Thiadiazole, 2,5-diphenyl- 1456-21-9
1,3,4-Thiadiazole-2,5-dithiol 1072-71-5
1,2,4-Thiadiazole, 3,5-dithio-, monopolymer 1072-71-5
1,2,4-Thiadiazole, 5-ethoxy-3-(trichloromethyl)- 2593-15-9
1,3,4-Thiadiazole, 2-ethylamino- 13275-68-8
2-Thenylamine, alpha-(m-fluorobenzyl)-N-isopropyl-,hydrochloride 80154-79-6
1,3,4-Thiadiazole, 2,2'-(methylenediimino)bis- 26907-37-9
1,3,4-Thiadiazole, 5-methyl-2-(2-oxazolin-2-ylamino)- 102367-72-6
1,3,4-Thiadiazole, 2-methyl-5-phenyl- 1456-72-0
1,2,4-Thiadiazole, 3-methyl-5-(phenylsulfonyl)- 21735-06-8
1,2,4-Thiadiazole, 3-methyl-5-(p-tolylsulfonyl)- 20064-41-9
1,3,4-Thiadiazole, 5-phenyl- 4291-14-9
1,3,4-Thiadiazole-2-sulfonamide, 5-amino-, monosodiumsalt 72296-05-0
1,3,4-Thiadiazole-2-sulfonamide,5-(((4-chlorophenyl)sulfonyl)amino)- 13463-26-8
1,3,4-Thiadiazole-2-sulfonamide, 5-phenyl- 63886-81-7
1,3,4-Thiadiazole-2-sulfonamide,5-((phenylsulfonyl)amino)- 3368-13-6
2-Thenylamine, alpha-(p-fluorobenzyl)-N-isopropyl-,hydrochloride 80154-82-1
1,3,4-Thiadiazole-2-thiol, 5-amino- 2349-67-9
1,2,4-Thiadiazole-3-thiol, 5-amino-, hydrochloride 63906-72-9
1,3,4-Thiadiazole-2-thiol, 5-amino-, hydrochloride 59909-21-6
1,3,4-Thiadiazole-2-thiol, 5-dimethylamino-,hydrochloride 63503-49-1
1,3,4-Thiadiazole-2-thiol, 5-(methylamino)-,hydrochloride 63503-51-5
1,3,4-Thiadiazole-2-thiol, 5-morpholino-,hydrochloride 63503-50-4
1,3,4-Thiadiazole-2-thiol, 5-phenyl- 5585-19-3
1,3,4-Thiadiazole-2(3H)-thione, 5-anilino- 10253-83-5
2H-1,3,4-Thiadiazole-2-thione, 5-mercapto-3-phenyl- 17654-88-5
1,3,4-Thiadiazole-2(3H)-thione,5,5'-(methylenediimino)bis- 79319-85-0

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