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MSDS  : 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-mandelamido-3-(((1-methyl- 1H-tetrazol-5-yl)thio)methyl)-8-oxo-, monosodium salt, D-
CAS  : 30034-03-8
SYNONYMS  : * Cefamandole sodium * Sodium cefamandole
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : XI0389000
CHEMICAL NAME : 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic
acid, 7-mandelamido-3-(((1-methyl-
1H-tetrazol-5-yl)thio)methyl)-8-oxo-, monosodium
salt, D-
CAS REGISTRY NUMBER : 30034-03-8
LAST UPDATED : 199507
DATA ITEMS CITED : 18
MOLECULAR FORMULA : C18-H17-N6-O5-S2.Na
MOLECULAR WEIGHT : 484.52
WISWESSER LINE NOTATION : T46 ANV ES GUTJ CMVYQR& HVO G1S- ET5NNNNJ A1 &-NA-
COMPOUND DESCRIPTOR : Reproductive Effector
SYNONYMS/TRADE NAMES :
* Cefamandole sodium
* Sodium cefamandole

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >16600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 26,115,1984

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 12100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 26,115,1984

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4410 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 26,115,1984

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >19900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 26,115,1984

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 10300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 26,115,1984

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4460 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 26,115,1984

TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
27(Suppl 5),701,1979

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2800 mg/kg/7D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
27(Suppl 5),701,1979

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 11 gm/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Specific Developmental Abnormalities - urogenital system
Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
27(Suppl 5),658,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 11 gm/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
27(Suppl 5),658,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 5500 mg/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
27(Suppl 5),658,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 13500 mg/kg
SEX/DURATION : female 17-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Maternal Effects - uterus, cervix, vagina
Reproductive - Effects on Newborn - physical
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
27(Suppl 5),682,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 5500 mg/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
27(Suppl 5),658,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 22 gm/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
27(Suppl 5),658,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 27 gm/kg
SEX/DURATION : female 17-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Maternal Effects - parturition
Reproductive - Effects on Newborn - physical
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
27(Suppl 5),682,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rabbit
DOSE : 780 mg/kg
SEX/DURATION : female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
27(Suppl 5),658,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rabbit
DOSE : 195 mg/kg
SEX/DURATION : female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
27(Suppl 5),658,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE : 390 mg/kg
SEX/DURATION : female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
27(Suppl 5),658,1979

*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
5-Thia-1-azabicyclo(4,2,0)oct-2-ene-2-carboxylicacid, 3-(hydroxymethyl)-8-oxo-7-(2-(4-pyridylthio)acetamido)-, acetate (ester), monosodiumsalt 24356-60-3
2-Thenylamine, N,N-bis(2-chloroethyl)-5-methyl- 3331-95-1
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 3-(hydroxymethyl)-8-oxo-7-(2-(2-thienyl)acetamido)-, acetate (ester) 153-61-7
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 3-(hydroxymethyl)-8-oxo-7-(2-(2-thienyl)acetamido)-, acetate, monosodium salt 58-71-9
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 3-(hydroxymethyl)-8-oxo-7-(2-(2-thienyl)acetamido)-, sodium salt 5547-29-5
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 7-(((((4-hydroxy-6-methyl-3-pyridinyl)carbonyl)amino)(4-hydroxyphenyl)acetyl)amino)-3-(((1-methyl-1H-t etrazol-5-yl)thio)methyl)-8-oxo-, monosodium salt,(6R-(6-alpha,7-beta(R*)))- 74849-93-7
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 7-((hydroxyphenylacetyl)amino)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-,(6R-(6-alpha,7-beta(R*)))- 34444-01-4
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-((hydroxyphenylacetyl)amino)-8-oxo-3-(((1-sulfomethyl)-1H-tetrazol-5-yl) thio)methyl)-,(6R-(6-alpha,7-beta(R*)))- 61270-58-4
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 7-(((((5-hydroxy-2-(1-piperazinyl)pyrido(2,3-d)pyrimidin-6-yl)carbonyl)amino)(4-hydroxyphenyl)acetyl)amino)- 3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, monosodium salt,(6R-(6-alpha,7-beta(R*)))- 60837-22-1
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 7-((((1-imino-2-phenylethyl)amino)acetyl)amino)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-, (6R-trans)- 40158-24-5
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 7-mandelamido-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, monosodiumsalt, D- 30034-03-8
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 7-(((1-(4-methoxyphenyl)cyclopentyl)carbonyl)amino)-3-methyl-8-oxo-, (6R-trans)- 108098-26-6
2-Thenylamine, N,N-bis(2-chloroethyl)-5-methyl-,hydrochloride 14742-54-2
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 7-(((1-(3-methoxyphenyl)cyclopropyl)carbonyl)amino)-3-methyl-8-oxo-, (6R-trans)- 108098-17-5
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 7-(((1-(4-methoxyphenyl)cyclopropyl)carbonyl)amino)-3-methyl-8-oxo-, (6R-trans)- 108098-18-6
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 3-methyl-8-oxo-7-(((1-phenylcyclopentyl)carbonyl)amino)-,(6R-trans)- 108098-25-5
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 3-methyl-8-oxo-7-(((1-phenylcyclopropyl)carbonyl)amino)-,(6R-trans)- 108098-16-4
5-Thia-1-azabicyclo(4,2,0)oct-2-ene-2-carboxylicacid, 3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-(6R,7R)-7-(2-(3,5-dichloro-4-oxo-1(4H)-pyridyl)acetamid o)-, monosodium salt 63521-15-3
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)- 25953-19-9
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-, mixed with sodium nitrite (1:4) 25953-19-9
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(((1H-tetrazol-1-yl)acetyl)amino)-, (6R-trans)-, sodium salt 27164-46-1
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 8-oxo-7-((1H-tetrazol-1-ylacetyl)amino)-3-((1,3,4-thiadiazol-2-ylthio)methyl)-,monosodium salt, (6R-trans)- 41136-22-5
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 7-(((1-(4-propoxyphenyl)cyclobutyl)carbonyl)amino)-3-methyl-8-oxo-, (6R-trans)- 108098-22-2
Tetrodotoxin, O(sup 4)-methyl- 7724-39-2
2-Thenylamine, alpha-(p-bromobenzyl)-, hydrochloride 80154-75-2
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 7-(((1-(2-propoxyphenyl)cyclopentyl)carbonyl)amino)-3-methyl-8-oxo-, (6R-trans)- 108098-30-2
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 7-(((1-(3-propoxyphenyl)cyclopentyl)carbonyl)amino)-3-methyl-8-oxo-, (6R-trans)- 108098-29-9
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 7-(((1-(4-propoxyphenyl)cyclopentyl)carbonyl)amino)-3-methyl-8-oxo-, (6R-trans)- 108098-28-8
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 7-(((1-(2-propoxyphenyl)cyclopropyl)carbonyl)amino)-3-methyl-8-oxo-, (6R-trans)- 108098-20-0
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid, 7-(((1-(4-propoxyphenyl)cyclopropyl)carbonyl)amino)-3-methyl-8-oxo-, (6R-trans)- 108146-11-8
1-Thia-3-aza-2-silacyclopentane,2-(p-chlorophenyl)-2,5-diphenyl- 102367-62-4
1-Thia-3-aza-2-silacyclopentane,2-(p-chlorophenyl)-2-methyl- 84260-43-5
1-Thia-3-aza-2-silacyclopentane, 2,2-diethyl- 84260-21-9
1-Thia-3-aza-2-silacyclopentane,2,2-diethyl-5-methyl- 84260-33-3
1-Thia-3-aza-2-silacylcopentane, 2,2-dimethyl- 84260-28-6
2-Thenylamine, alpha-(p-bromobenzyl)-N-isopropyl-,hydrochloride 80154-76-3
1-Thia-3-aza-2-silacyclopentane,2,5-dimethyl-2-(p-fluorophenyl)- 84260-41-3
1-Thia-3-aza-2-silacyclopentane,2,5-dimethyl-2-(p-methoxyphenyl)- 84260-39-9
1-Thia-3-aza-2-silacyclopentane,2,5-dimethyl-2-phenyl- 84260-31-1
1-Thia-3-aza-2-silacyclopentane, 2,2-diphenyl- 84260-35-5
1-Thia-3-aza-2-silacyclopentane,2-(p-fluorophenyl)-2-methyl- 84260-27-5
1-Thia-3-aza-2-silacyclopentane,2-(p-methoxyphenyl)-2-methyl- 84260-25-3
1-Thia-3-aza-2-silacyclopentane, 2-methyl-2-phenyl- 84260-23-1
1-Thia-3-aza-2-silacyclopentane,2-methyl-2-(p-tolyl)- 84260-37-7
1-Thia-4-azaspiro(4.5)decane, 8-methyl-,hydrochloride 31404-04-3
2-Thia-7-azaspiro(4.4)nonane-6,8-dione, 7-allyl- 10288-31-0
3-Thenylamine, 2-bromo-N,N-bis(2-chloroethyl)-,hydrochloride 13792-99-9
7-Thiabicyclo(2.2.1)heptane-2,3-dicarboxylic acid,(exo,exo)- 109282-39-5
9-Thiabicyclo(3.3.1)nonane, 2,6-dichloro- 6522-21-0
8-Thia-1,3-diazaspiro(4.5)decane-2,4-dione 39124-15-7

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