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MSDS  : 1-alpha-H,5-alpha-H-Tropane, 3-alpha-((10,11-dihydro-5H-dibenzo(ad)cyclohepten-5-y l)oxy)-, citrate (1:1)
CAS  : 2169-75-7
SYNONYMS  : * Brontin * Brontina * Brontine * Brontisol * BS 6987 * Deptrin * Deptropine citrate * Dibenzheptropine * Dibenzheptropine citrate * 3-alpha-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yloxy)tropane citrate * 3-alpha-((10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)oxy)tropan dihydrogen citrate * Elamol * Elargin * Elargyl * SU-Brontine
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : YM3065000
CHEMICAL NAME : 1-alpha-H,5-alpha-H-Tropane,
3-alpha-((10,11-dihydro-5H-dibenzo(ad)cyclohepten-5-y
l)oxy)-, citrate (1:1)
CAS REGISTRY NUMBER : 2169-75-7
LAST UPDATED : 199509
DATA ITEMS CITED : 6
MOLECULAR FORMULA : C23-H27-N-O.C6-H8-O7
MOLECULAR WEIGHT : 525.65
WISWESSER LINE NOTATION : L C676&T&J BO- GT56 A ANTJ A1
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Brontin
* Brontina
* Brontine
* Brontisol
* BS 6987
* Deptrin
* Deptropine citrate
* Dibenzheptropine
* Dibenzheptropine citrate
* 3-alpha-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yloxy)tropane citrate
* 3-alpha-((10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)oxy)tropan
dihydrogen citrate
* Elamol
* Elargin
* Elargyl
* SU-Brontine

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 445 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 148,135,1964

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 23,854,1973

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 66 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 23,854,1973

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 32 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam,
Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ.
Volume(issue)/page/year: 11,104,1962

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - ataxia
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 148,135,1964

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2352 mg/kg/8W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam,
Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ.
Volume(issue)/page/year: 11,104,1962

*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
1-alpha-H,5-alpha-H-Tropane,3-alpha-((10,11-dihydro-3-bromo-5H-dibenzo(a,d)cyclohepten- 5-yl)oxy)-, maleate (1:1) 15475-51-1
Tropane,3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)- 27830-75-7
1-alpha-H,5-alpha-H-Tropane,3-alpha-((10,11-dihydro-5H-dibenzo(ad)cyclohepten-5-yl)oxy)-, citrate (1:1) 2169-75-7
1-alpha-H,5-alpha-H-Tropane,3-beta-((10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)oxy)-, fumarate (1:1) 15620-20-9
1-alpha-H,5-alpha-H-Tropane,3-alpha-((10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)oxy)-, maleate (1:1) 15475-43-1
(1,2,4)Triazolo(1,5-c)pyrimidin-5(6H)-one, 7-amino- 129147-77-9
1-alpha-H,5-alpha-H-Tropane,3-alpha-((10,11-dihydro-3-methyl-5H-dibenzo(a,d)cyclohepten-5- yl)oxy)-, maleate (1:1) 10140-01-9
1-alpha-H,5-alpha-H-Tropane,3-alpha-((10,11-dihydro-1-methyl-5H-dibenzo(a,d)cyclohepten-5- yl)oxy)-, oxalate (1:1) 15620-21-0
Tropane,3-alpha-((4,9-dihydrothieno(2,3-c)(2)benzothiepin-4-yl)oxy)-, maleate (1:1) 15620-21-0
1-alpha-H,5-alpha-H-Tropane,3-alpha-(diphenylmethoxy)- 86-13-5
1-alpha-H,5-alpha-H-Tropane,3-alpha-(diphenylmethoxy)-, methanesulfonate 132-17-2
1-alpha-H,5-alpha-H-Tropane,3-(alpha-diphenylmethoxy)-9-methyl-, bromide 132-17-2
Tropane, hydrochloride 23555-06-8
1-alpha-H,5-alpha-H-Tropane,3-alpha-((3-methyl-5H-dibenzo(a,d)cyclohepten-5-yl)oxy)-, maleate (1:1) 10140-00-8
1-alpha-H,5-alpha-H-Tropane,3-alpha-((o-methyl-alpha-phenylbenzyl)oxy)-,hydrochloride 10140-00-8
Tropane, 3-alpha-phenyl-, hydrochloride 64838-10-4
7H-v-Triazolo(4,5-d)pyrimidin-7-one,5-amino-1,6-dihydro- 134-58-7
Tropane, 3-beta-phenyl-, hydrochloride 64838-02-4
Tropane-8-propionamide,3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yloxy),oxime, di(hydrogen maleate) 73953-98-7
Tropane-8-propionamide, 3-hydroxy-, oxime,dihydrochloride 73953-99-8
Tropane-8-propionitrile,3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yloxy)-, hydrogen maleate 73954-01-5
1-alpha-H,5-alpha-H-Tropane,3-alpha-((5,6,7,12-tetrahydrodibenzo(a,d)cycloocten-2-yl)oxy)-, fumarate (1:1) 15620-25-4
Tropane, 3-alpha-(alpha-o-tolylbenzyloxy)-,hydrobromide 31642-65-6
Tropane,3-(alpha-(alpha,alpha,alpha-trifluoro-m-tolyl)benzyloxy)-, fumarate 3216-12-4
Tropane,3-(alpha-(alpha,alpha,alpha-trifluoro-o-tolyl)benzyloxy)-, fumarate 3216-12-4
Tropane,3-(alpha-(alpha,alpha,alpha-trifluoro-p-tolyl)benzyloxy)-, fumarate 3560-78-9
1-alpha-H,5-alpha-H-Tropanium,8-allyl-2-beta-carboxy-3-beta-hydroxy-, bromide,methyl ester, benzoate 21416-05-7
7H-v-Triazolo(4,5-d)pyrimidin-7-one,5-amino-3,6-dihydro-3-beta-D-ribofuranosyl 2133-80-4
1-alpha-H,5-alpha-H-Tropanium, 8-benzyl-3-hydroxy-,bromide, p-aminobenzilate (ester) 63977-75-3
1-alpha-H,5-alpha-H-Tropanium, 8-benzyl-3-hydroxy-,bromide, benzilate (ester) 63977-76-4
1-alpha-H,5-alpha-H-Tropanium,8-benzyl-3-alpha-hydroxy-, bromide, benzilate (ester) 63977-77-5
1-alpha-H,5-alpha-H-Tropanium, 8-benzyl-3-hydroxy-,bromide, maleate (ester) 63977-78-6
1-alpha-H,5-alpha-H-Tropanium,8-benzyl-3-alpha-hydroxy-, bromide, (+-)-tropate 102432-87-1
1-alpha-H,5-alpha-H-Tropanium,4,4'-biphenylenebis(3-alpha-hydroxy-8-methyl-,dibromide 379-85-1
1-alpha-H,5-alpha-H-Tropanium,4,4'-biphenylenebis(3-beta-hydroxy-8-methyl-,dibromide 337-79-1
1-alpha-H,5-alpha-H-Tropanium,4,4'-biphenylenebis(3-alpha-hydroxy-8-methyl-,dibromide, benzylate (ester) 337-76-8
1-alpha-H,5-alpha-H-Tropanium,4,4'-biphenylenebis(3-alpha-hydroxy-8-methyl-,dibromide, benzylcarbonate (ester) 337-78-0
1-alpha-H,5-alpha-H-Tropanium,4,4'-biphenylenebis(3-alpha-hydroxy-8-methyl-,dibromide, p-chlorobenzoate (ester) 337-75-7

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