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MSDS  : Valinomycin
CAS  : 2001-95-8
SYNONYMS  : * Antibiotic N-329 B * NSC 122023 * Valinomicin
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : YV9468000
CHEMICAL NAME : Valinomycin
CAS REGISTRY NUMBER : 2001-95-8
OTHER CAS REGISTRY NOS. : 11005-80-4
BEILSTEIN REFERENCE NO. : 0078657
REFERENCE : 4-27-00-09728 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 8
MOLECULAR FORMULA : C54-H90-N6-O18
MOLECULAR WEIGHT : 1111.50
WISWESSER LINE NOTATION : T-36-MV DOV GMV JOV MMV POV SMV VOV B&MV E&OV H&MV
K&OVTJ C1 FY1&1 IY1&1 LY1&1 O1 RY1&1 UY1&1
COMPOUND DESCRIPTOR : Drug
Natural Product
SYNONYMS/TRADE NAMES :
* Antibiotic N-329 B
* NSC 122023
* Valinomicin

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 800 ug/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
eds., Washington, DC, American Soc. for Microbiology, 1978
Volume(issue)/page/year: 1,325,1978

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 390 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary,
Developmental Therapeutics Program. (Bethesda, MD 20205)
Volume(issue)/page/year: JAN1986

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4140 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 12,482,1962

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 180 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
46,5518,1986

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 5 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
L-Valine,N-(3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(Z)-2,3-dide hydro-2- aminobutanoyl-,ti-lactone, cyclic (1-2)-disulfide, (S-(E))- 128517-07-7
Valine, N-(3-indolyloxalyl)-, DL- 97500-64-6
DL-Valine, N-(1H-indol-3-yloxoacetyl)-, ethyl ester 97529-41-4
Valine, 3-mercapto-, D- 52-67-5
Valine, 3-mercapto-, DL- 52-66-4
Valine, 3-mercapto-, L- 1113-41-3
Valeramide,N-butyl-N-(3-methyl-2-norbornylmethyl)-4-oxo- 28939-71-1
Valine, N-(mercaptoacetyl)-, ethyl ester, S-esterwith O,O-diethyl phosphorodithioate, D- 73175-09-4
Valine, N-(mercaptoacetyl)-, ethyl ester, S-esterwith O,O-diethyl phosphorodithioate, DL- 19476-82-5
Valine, N-(mercaptoacetyl)-, ethyl ester, S-esterwith O,O-diethyl phosphorothioate, D- 73175-10-7
Valine, N-(mercaptoacetyl)-, ethyl ester, S-esterwith O,O-diethyl phosphorothioate, DL- 73175-11-8
Valine, 3-mercapto-, butyl ester, hydrochloride, DL- 73175-11-8
Valine, 3-mercapto-, hydrochloride, D- 2219-30-9
Valine, 3-mercapto-, hydrochloride, DL- 22572-05-0
Valine,3-mercapto-N-(3,4,5,6-tetrahydro-2-pyridinyl)- 105112-32-1
DL-Valine, N-(2-(4-methoxybenzoyl)ethyl)-,hydrochloride 17935-47-6
Valine, monosodium salt, L- 34241-42-4
Valeramide, N-butyl-3-oxo-2,2,4-trimethyl- 24388-85-0
L-Valine,2-(2-oxo-2-(10H-phenothiazin-10-yl)ethyl)hydrazide 84409-79-0
DL-Valine, N-(1-oxo-3-phenyl-2-propenyl)-, methylester, (E)- 127750-57-6
DL-Valine, N-(3-oxo-3-phenylpropyl)-, hydrochloride 92514-97-1
L-Valine,N-(((1-phenyl-1H-tetrazol-5-yl)thio)acetyl)-, ethylester 133526-79-1
Valine, 2-(5-phenyl-3-as-triazinyl)hydrazide,dihydrobromide, hydrate 70701-64-3
Valinomycin 2001-95-8
Vallaris solanacea O. Ktze (H. Ramsar), leaf extractSUBSTANCE DEFINITION :Plant belonging to the family ApocynaceaeREFERENCE :JSICAZ Journal of Scientific and Industrial Research, Section C: BiologicalSciences. (New Delhi, India) V.14-21, 1955-62. For publisher information,see IJEBA6. Volume(issue)/page/year: 20,21,1961 2001-95-8
Vallaris solanacea O. Kuntze, extractSUBSTANCE DEFINITION :Plant belonging to the family ApocynaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- 2001-95-8
Vallaroside 4477-75-2
Vallaroside, mono-O-acetyl- 4356-53-0
Urushiol, poison oakSUBSTANCE DEFINITION :The composition of poison oak urushiol was 6.8% mono-, 10.2% di- and 83%triolefinREFERENCE :TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,Limerick, Ireland) V.1- 1973- 4356-53-0
Valeramide, N-butyl-2-phenethyl- 4356-53-0
Vallicepo-bufaginSUBSTANCE DEFINITION :Separated from the parotid secretion of Bufo vallicepsREFERENCE :JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-Volume(issue)/page/year: 49,526,1933 4356-53-0
Valmane 78769-65-0
Valonea tannin 78769-65-0
Valoton 76775-57-0
Vanadate(2-), bis(eta(sup5)-2,4-cyclopentadien-1-yl)(2-hydroxy-1,2,3-propanetricarboxylato( 3-))-, dihydrogen 84822-40-2
Vanadate(3-), hexafluoro-, triammonium salt 13815-31-1
Vanadic acid, ammonium salt 7803-55-6
Vanadic acid, monosodium salt 13718-26-8
Vanadic acid, monosodium salt, hydrate 20740-98-1
Vanadic acid, monosodium salt, tetrahydrate 20740-98-1
Valeramide, N-butyl-2-propyl- 2936-13-2
Vanadic acid, potassium salt 13769-43-2
Vanadic acid, triisobutyl ester 19120-62-8
Vanadic(II) acid, trisodium salt 13721-39-6
Vanadic acid(II), trisodium salt, dodecahydrate 13721-39-6
Vanadious(4+) acid, disodium salt 64082-34-4
Vanadium 7440-62-2
Vanadium, (eta(sup5)-2,4-cyclopentadien-1-yl)bis(2-hydroxypropanoato-O(sup 1),O(sup 2))- 102511-51-3
Vanadium dichloride 10580-52-6
Vanadium, dichlorodi-pi-cyclopentadienyl- 12083-48-6

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