RTECS NUMBER : YX3966100
CHEMICAL NAME : Venom, scorpion, Opisthophthalmus glabrifrons
LAST UPDATED : 199109
DATA ITEMS CITED : 10
COMPOUND DESCRIPTOR : Natural Product
SYNONYMS/TRADE NAMES :
* Opisthophthalmus glabrifrons venom
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Behavioral - irritability
Skin and Appendages - primary irritation (after topical exposure)
REFERENCE :
TRSTAZ Transactions of the Royal Society of Tropical Medicine and Hygiene.
(Royal Soc. of Tropical Medicine and Hygiene, Manson House, 26 Portland Pl.,
London W1N 4EY, UK) V.14- 1920- Volume(issue)/page/year: 39,397,1946
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory
change
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
TRSTAZ Transactions of the Royal Society of Tropical Medicine and Hygiene.
(Royal Soc. of Tropical Medicine and Hygiene, Manson House, 26 Portland Pl.,
London W1N 4EY, UK) V.14- 1920- Volume(issue)/page/year: 39,397,1946
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TRSTAZ Transactions of the Royal Society of Tropical Medicine and Hygiene.
(Royal Soc. of Tropical Medicine and Hygiene, Manson House, 26 Portland Pl.,
London W1N 4EY, UK) V.14- 1920- Volume(issue)/page/year: 39,397,1946
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intracerebral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 500 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
TRSTAZ Transactions of the Royal Society of Tropical Medicine and Hygiene.
(Royal Soc. of Tropical Medicine and Hygiene, Manson House, 26 Portland Pl.,
London W1N 4EY, UK) V.14- 1920- Volume(issue)/page/year: 39,397,1946
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >17200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
UK) V.1- 1962- Volume(issue)/page/year: 9,1,1971
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 7500 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory
change
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TRSTAZ Transactions of the Royal Society of Tropical Medicine and Hygiene.
(Royal Soc. of Tropical Medicine and Hygiene, Manson House, 26 Portland Pl.,
London W1N 4EY, UK) V.14- 1920- Volume(issue)/page/year: 39,397,1946
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 120 mg/kg
TOXIC EFFECTS :
Blood - hemorrhage
Skin and Appendages - corrosive (after topical exposure)
REFERENCE :
TRSTAZ Transactions of the Royal Society of Tropical Medicine and Hygiene.
(Royal Soc. of Tropical Medicine and Hygiene, Manson House, 26 Portland Pl.,
London W1N 4EY, UK) V.14- 1920- Volume(issue)/page/year: 39,397,1946
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Bird - pigeon
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Blood - hemorrhage
Skin and Appendages - primary irritation (after topical exposure)
REFERENCE :
TRSTAZ Transactions of the Royal Society of Tropical Medicine and Hygiene.
(Royal Soc. of Tropical Medicine and Hygiene, Manson House, 26 Portland Pl.,
London W1N 4EY, UK) V.14- 1920- Volume(issue)/page/year: 39,397,1946
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Bird - pigeon
DOSE/DURATION : 6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TRSTAZ Transactions of the Royal Society of Tropical Medicine and Hygiene.
(Royal Soc. of Tropical Medicine and Hygiene, Manson House, 26 Portland Pl.,
London W1N 4EY, UK) V.14- 1920- Volume(issue)/page/year: 39,397,1946
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Bird - pigeon
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
REFERENCE :
TRSTAZ Transactions of the Royal Society of Tropical Medicine and Hygiene.
(Royal Soc. of Tropical Medicine and Hygiene, Manson House, 26 Portland Pl.,
London W1N 4EY, UK) V.14- 1920- Volume(issue)/page/year: 39,397,1946
*** END OF RECORD ***
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