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MSDS  : Zinc, bis(2-pyridylthio)-, N,N'-dioxide
CAS  : 13463-41-7
SYNONYMS  : * Bis(1-hydroxy-2(1H)-pyridinethionato)zinc * OM-1563 * Omadine Zinc * 2-Pyridinethiol-1-oxide, zinc salt * Pyrithione zinc * Vancide P * Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)- * Zinc, bis(1-hydroxy-2(1H)-pyridinethionato-O,S)-, (T-4)- * Zinc, bis(2-pyridylthio)-, 1,1'-dioxide * Zinc omadine * Zincpolyanemine * Zinc PT * Zinc pyridine-2-thiol-1-oxide * Zinc 2-pyridinethiol-1-oxide * Zinc pyridinethione * Zinc pyrion * Zinc pyrithione * ZnPT * ZPT
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : ZH0950000
CHEMICAL NAME : Zinc, bis(2-pyridylthio)-, N,N'-dioxide
CAS REGISTRY NUMBER : 13463-41-7
LAST UPDATED : 199710
DATA ITEMS CITED : 27
MOLECULAR FORMULA : C10-H8-N2-O2-S2-Zn
MOLECULAR WEIGHT : 317.69
WISWESSER LINE NOTATION : T6NJ AO BS-ZN-S- BT6NJ AO
COMPOUND DESCRIPTOR : Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Bis(1-hydroxy-2(1H)-pyridinethionato)zinc
* OM-1563
* Omadine Zinc
* 2-Pyridinethiol-1-oxide, zinc salt
* Pyrithione zinc
* Vancide P
* Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)-
* Zinc, bis(1-hydroxy-2(1H)-pyridinethionato-O,S)-, (T-4)-
* Zinc, bis(2-pyridylthio)-, 1,1'-dioxide
* Zinc omadine
* Zincpolyanemine
* Zinc PT
* Zinc pyridine-2-thiol-1-oxide
* Zinc 2-pyridinethiol-1-oxide
* Zinc pyridinethione
* Zinc pyrion
* Zinc pyrithione
* ZnPT
* ZPT

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1 mg/48H
REFERENCE :
JANCA2 Journal of the Association of Official Analytical Chemists. (Assoc.
of Official Analytical Chemists, 1111 N. 19th St., Suite 210, Arlington, VA
22209) V.49- 1966- Volume(issue)/page/year: 56,905,1973

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 177 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOANDB Toxicology Annual. (New York, NY) 1974/75-79. Discontinued.
Volume(issue)/page/year: 3,1,1979

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 140 mg/m3/4H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
Lungs, Thorax, or Respiration - dyspnea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0527753-1

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 13,1,1978

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 26800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,1067,1974

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 730 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 13,1,1978

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 13,1,1978

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - somnolence (general depressed activity)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,269,1966

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,269,1966

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
Japan) V.1- 1950- Volume(issue)/page/year: 32,965,1981

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,269,1966

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
7,425,1965

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 140 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of Pesticides
and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
Washington, DC 20460) History unknown. Volume(issue)/page/year:
8EHQ-0790-1035

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 42 mg/kg/14D-C
TOXIC EFFECTS :
Peripheral Nerve and Sensation - recording from peripheral motor nerve
Behavioral - muscle weakness
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year:
12,153,1990

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 300 mg/kg/15D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory
change
Related to Chronic Data - death
REFERENCE :
50TXAR "Cutaneous Toxicity, base on Papers presented at the Conference on
Cutaneous Toxictiy, 5th, New York, May 6-18, 1982," Drill, V.A. and P. Lazar
eds. Raven Press 1984 Volume(issue)/page/year: 5,109,1984

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 350 mg/kg/14D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - retinal changes (pigmentary
depositions, retinitis, other)
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
45,771,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 840 mg/kg/28D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
45,771,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 100 mg/kg/8D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
45,771,1978

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 150 mg/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,639,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE : 75 mg/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,639,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE : 1065 mg/kg
SEX/DURATION : female 8 week(s) pre-mating
female 1-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,639,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE : 65 mg/kg
SEX/DURATION : female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,639,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE : 1300 mg/kg
SEX/DURATION : female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,639,1979

*** U.S. STANDARDS AND REGULATIONS ***

EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83016
No. of Facilities: 43 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 387 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998


*** END OF RECORD ***
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Zinc, bis(N-methylpropanamide-N)bis(nitrato-O)-,(T-4)- 90910-85-3
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Zinc, bis(N-methylpropanamide-N)(sulfato(2-)-O)- 90910-83-1
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Zinc, bis(pentachlorophenylthio)- 117-97-5
Zinc, bis(2,4-pentanedionato)- 14024-63-6
Zinc, bis(1-piperidinecarbodithioato)- 13878-54-1
Zinc, bis(3-pyridinecarboxamide-N(sup1))(sulfato(2-)-O)- 90910-80-8
Zinc, bis(2-pyridylthio)-, N,N'-dioxide 13463-41-7
Zinc(II), bis(5-sulfo-8-quinolinolato-N(sup 1),O(sup8))- 14494-69-0
Zinc, bis(2,3,5-trichlorophenylthio)- 63885-02-9
Zinc bromide 7699-45-8
Venom, snake, Trimeresurus gravemineus 7699-45-8
Venom, wasp, Paravespula maculifrons, worker 7699-45-8
Zinc chloride 7646-85-7
Zinc cyanide 557-21-1
Zinc, (cyclohexylamine)bis(dimethyldithiocarbamato)- 16509-79-8
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Zinc,dichloro(4,4-dimethyl-5-((((methylamino)carbonyl)oxy)imino)pentanenitrile) -, (T-4)- 58270-08-9
Zinc, (dihydrogen chlorophyllinato(2-))-, dipotassiumsalt 58270-08-9
Zinc,(ethanedioato(2-)-O,O')-bis(3-pyridinecarboxamide-N(sup 1))-, (T-4)- 90910-81-9
Zinc, ((1,2-ethanediylbis(carbamodithioato))(2-))-,mixt. with copper chloride oxide hydrate 8066-21-5
Zinc, (ethylenebis(dithiocarbamato))- 12122-67-7
Venom, wasp, Polistes infuscatus 12122-67-7
Zinc,(dimethylthiocarbamato)(ethylenebis(dithiocarbamato))- 12122-67-7
Zinc fluoride 7783-49-5
Zinc gluconate 4468-02-4
Zinc hydroxide 20427-58-1
Zinc(1+), (isonicotinic acid hydrazide)-, sulfate,dihydrate 20427-58-1
Zinc mercury chromate complex 22323-45-1
Zinc,(3-(1-methyl-2-pyrrolidinyl)pyridine)bis(thiocyanato)-, (S)- 64092-25-7
Zinc(II) nitrate, hexahydrate (126) 10196-18-6
Zinc oleate (12) 557-07-3
Zinc oxide 1314-13-2
Venom, wasp, Polybia sericea 1314-13-2
Zinc oxide (ointment) 1314-13-2
Zinc permangante 23414-72-4
Zinc, Complex with 1,10-phenanthrolinylene 16561-55-0
Zinc phosphide 1314-84-7
Zinc, (N,N'-propylene-1,2-bis(dithiocarbamate)) 12071-83-9

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