RTECS NUMBER : CY1576890
CHEMICAL NAME : Benzeneacetic acid, alpha-cyclohexyl-alpha-hydroxy-,
(4-diethylamino)-1,1-dimethyl- 2-buteynyl ester,
hydrochloride
CAS REGISTRY NUMBER : 129927-33-9
OTHER CAS REGISTRY NOS. : 136529-33-4
LAST UPDATED : 199712
DATA ITEMS CITED : 2
MOLECULAR FORMULA : C24-H35-N-O3.Cl-H
MOLECULAR WEIGHT : 422.06
COMPOUND DESCRIPTOR : Reproductive Effector
SYNONYMS/TRADE NAMES :
* (+-)-4-Diethylamino-1,1-dimethylbut-2-yn-1-yl
2-cyclohexyl-2-hydroxy-2-phenylacetate HCl H2O
* NS-21
* Urespan
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 40 gm/kg
SEX/DURATION : male 60 day(s) pre-mating
female 14 day(s) pre-mating - 7 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 22(Suppl
1),201,1997
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 8100 mg/kg
SEX/DURATION : female 17-21 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 22(Suppl
1),239,1997
*** END OF RECORD ***
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