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MSDS  : Benzenepropanamine, N-methyl-gamma-(4-(trifluoromethyl)phenoxy)-, (+-)-
CAS  : 54910-89-3
SYNONYMS  : * Fluoxetine * (+-)-N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine * Prozac
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : DA8326855
CHEMICAL NAME : Benzenepropanamine,
N-methyl-gamma-(4-(trifluoromethyl)phenoxy)-, (+-)-
CAS REGISTRY NUMBER : 54910-89-3
LAST UPDATED : 199801
DATA ITEMS CITED : 9
MOLECULAR FORMULA : C17-H18-F3-N-O
MOLECULAR WEIGHT : 309.36
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Fluoxetine
* (+-)-N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine
* Prozac

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 60 mg/kg/21W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - other changes
REFERENCE :
AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc.,
Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921-
Volume(issue)/page/year: 153,134,1996

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 72 mg/kg/26W-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
JCPYDR Journal of Clinical Pyschopharmacology. (Williams & Wilkins Co., 428
E. Preston St., Baltimore, MD 21202) V.1- 1981- Volume(issue)/page/year:
10,343,1990

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 16800 ug/kg/6W-I
TOXIC EFFECTS :
Behavioral - muscle weakness
Behavioral - antipsychotic
Nutritional and Gross Metabolic - other changes
REFERENCE :
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago,
IL 60610) V.1- 1908- Volume(issue)/page/year: 156,681,1996

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 2 mg/kg/5D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Nutritional and Gross Metabolic - other changes
REFERENCE :
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago,
IL 60610) V.1- 1908- Volume(issue)/page/year: 156,681,1996

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 825 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
15,1178,1990

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 121 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
15,1178,1990

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 464 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
15,1178,1990

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 87500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
15,1178,1990

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 80 mg/kg
SEX/DURATION : female 13-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 280,138,1997

*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Benzenepropanamide,alpha-(benzoylamino)-4-(2-(diethylamino)ethoxy)-N-propyl-, (+-)- 102579-43-1
Benzenepropanamide,alpha-(benzoylamino)-N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H- pyrazol-4-yl)-, (S)- 151921-19-6
Benzenepropanamide,alpha-(benzoylamino)-4-(2-(ethylamino)ethoxy)-N,N-dipropyl-, (+-)- 151921-19-6
Benzeneethanol,beta-((dimethylamino)methyl)-alpha-ethyl-alpha-phenyl-, hydrochloride 37013-30-2
Benzenepropanamine,3-chloro-4-cyclohexyl-N,N-diethyl-, hydrochloride 56760-06-6
Benzenepropanamine,3-chloro-4-cyclohexyl-N,N-dimethyl-, hydrochloride 56760-07-7
Benzenepropanamide,N,N-diethyl-alpha-((2-hydroxybenzoyl)amino)- 56146-09-9
Benzenepropanamide,N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-alpha- (dimethylamino)-, (+-)- 62951-81-9
Benzenepropanamide,4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-beta-methyl-alpha-oxo- 67358-82-1
Benzenepropanamide, 3,4-dimethoxy- 67358-82-1
Benzenepropanamide,N,N-dimethyl-alpha-(dimethylamino)-beta-ethenyl- 111983-66-5
Benzenepropanamide,N,N-dimethyl-alpha-((2-hydroxybenzoyl)amino)- 56146-08-8
Benzenepropanamine, N,N-dimethyl-gamma-2-propenyl-,hydrochloride 62114-73-2
Benzenepropanamine, N,gamma-di-2-propenyl-N-methyl-,hydrochloride 62114-74-3
Benzeneethanol,beta-(2-(dimethylamino)propyl)-alpha-ethyl-alpha-phenyl-, acetate (ester), hydrochloride, (R*,S*)-(+-)- 5988-48-7
Benzenepropanamide,N,N'-(dithiodi-2,1-ethanediyl)bis(alpha-amino-,(S-(R*,R*))-, bis(trifluoroacetate) 117507-07-0
Benzenepropanamide, beta-ethyl-beta-hydroxy- 5579-03-3
Benzenepropanamide,N-ethyl-alpha-((2-hydroxybenzoyl)amino)- 56146-07-7
Benzenepropanamide, alpha-((2-hydroxybenzoyl)amino)- 56146-06-6
Benzenepropanamide,alpha-((2-hydroxybenzoyl)amino)-N-(phenylmethyl)- 56146-10-2
Benzenepropanamide, beta-hydroxy-2-methyl-, (+-)- 146669-24-1
Benzenepropanamide,N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl)-,monohydrochloride 35630-95-6
Benzenepropanamide,4-methoxy-N-(4,8,8-trimethyl-1-azatricyclo(3.3.1.1(sup 3,7))dec-4-yl)- 86706-09-4
Benzenepropanamide,beta-phenyl-N-(4,8,8-trimethyl-1-azatricyclo(3.3.1.1(sup 3,7))dec-4-yl)- 86706-11-8
Benzenepropanamide,N-(4,8,8-trimethyl-1-azatricyclo(3.3.1.1(sup3,7))dec-4-yl)- 86706-07-2
Benzeneethanol,beta-(2-(dimethylamino)propyl)-alpha-ethyl-beta-phenyl-, acetate (ester), hydrochloride, (R-(R*,R*))- 53757-35-0
Benzenepropanamine,N-methyl-N-(phenylmethyl)-gamma-2-propenyl-,hydrochloride 62114-75-4
Benzenepropanamine, N-methyl-gamma-2-propenyl-,hydrochloride 62114-72-1
Benzenepropanamine,gamma-((2-chloro-10,11-dihydro(b,f)thiepin-10-yl)thio)-N,N-dimethyl-, (+-)-, ethanedioate (1:1) 62114-72-1
Benzenepropanamine,3,5-dichloro-beta-(3,5-dichloro-2-(phenylthio)phenyl)-N,N-dimethyl- 2-(phenylthio)- 79332-43-7
Benzenepropanamine,3,5-dichloro-beta-(3,5-dichloro-2-(phenylthio)phenyl)-2-(phenylthio)- 79332-40-4
Benzenepropanamine, 3,4-dimethoxy-alpha-methyl-,hydrochloride, (+-)- 53581-64-9
Benzenepropanamide, N-(2-(dimethylamino)ethyl)- 63224-24-8
Benzenepropanamine,alpha,alpha-dimethyl-gamma-phenyl, maleate 56740-60-4
Benzenepropanamine,N,N-dimethyl-gamma-(2-(phenylmethoxy)phenoxy)-,ethanedioate (1:1) 79332-97-1
Benzenepropanamine,gamma-(ethylsulfonyl)-N,N,alpha-trimethyl-gamma-phenyl-, hydrochloride 60662-79-5
Benzeneethanol,beta-(2-(dimethylamino)propyl)-alpha-ethyl-beta-phenyl-, acetate (ester), hydrochloride, (R-(R*,S*))- 61443-59-2
Benzenepropanamine,N-methyl-gamma-(2-(phenylmethoxy)phenoxy)-,hydrochloride 79332-99-3
Benzenepropanamine,N-methyl-gamma-(4-(trifluoromethyl)phenoxy)-, (+-)- 54910-89-3
Benzenepropanamine, alpha-methyl-2,3,4-trimethoxy-,hydrochloride, (+-)- 53581-68-3
Benzenepropanamine, alpha-methyl-2,4,6-trimethoxy-,hydrochloride, (+-)- 53581-67-2
Benzenepropanamine, beta-phenyl-, hydrochloride 40692-28-2
Benzenepropanamine,gamma-phenyl-N,N,alpha,alpha-tetramethyl-,hydrochloride 56740-68-2
Benzenepropanamine,gamma-phenyl-N,N,gamma-trimethyl-, (Z)-2-butenedioate(1:1) 37014-81-6
Benzenepropanamine,gamma-phenyl-N,alpha,alpha-trimethyl-, hydrochloride 56740-64-8
Benzenepropanaminium,3,4-dimethoxy-gamma-oxo-N,N,N-trimethyl-, iodide 127119-33-9
Benzene,1,1'-(1,3-propanediylbis(oxy))bis(4-(2-cyclopenten-1-yl)- 105886-90-6
Benzeneethanol,beta-(2-(dimethylamino)propyl)-alpha-ethyl-beta-phenyl-, acetate (ester), hydrochloride, (S-(R*,S*))- 61443-60-5
Benzenepropanenitrile, 4-amino-beta-oxo- 59443-94-6
Benzenepropanenitrile,4-chloro-beta-(1-methylethyl)-alpha-(3-phenoxyphenyl)- 66753-10-4

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