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MSDS  : Benzilic acid, 3-quinuclidinyl ester
CAS  : 6581-06-2
SYNONYMS  : * 1-Azabicyclo(2.2.2)octan-3-ol, benzilate * 3-Chinuclidylbenzilate * CS 4030 * EA 2277 * QNB * 3-Quinuclidinol benzilate * 3-Quinuclidinyl benzilate * 3-Quinuclidyl benzilate * Ro 2-3308
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : DD4638000
CHEMICAL NAME : Benzilic acid, 3-quinuclidinyl ester
CAS REGISTRY NUMBER : 6581-06-2
LAST UPDATED : 199604
DATA ITEMS CITED : 9
MOLECULAR FORMULA : C21-H23-N-O3
MOLECULAR WEIGHT : 337.45
WISWESSER LINE NOTATION : T66 A B CNTJ AOVXQR&R
COMPOUND DESCRIPTOR : Mutagen
Human
SYNONYMS/TRADE NAMES :
* 1-Azabicyclo(2.2.2)octan-3-ol, benzilate
* 3-Chinuclidylbenzilate
* CS 4030
* EA 2277
* QNB
* 3-Quinuclidinol benzilate
* 3-Quinuclidinyl benzilate
* 3-Quinuclidyl benzilate
* Ro 2-3308

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 4500 ng/kg
TOXIC EFFECTS :
Cardiac - change in rate
REFERENCE :
85IVAW "Possible Long-Term Health Effects of Short-Term Exposure to Chemical
Agents," National Research Council, 3 vols., Washington, DC, National
Academy Press, 1982-85 Volume(issue)/page/year: 1,63,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human
DOSE/DURATION : 4800 ng/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - local anesthetic
Behavioral - hallucinations, distorted perceptions
Behavioral - ataxia
REFERENCE :
85IVAW "Possible Long-Term Health Effects of Short-Term Exposure to Chemical
Agents," National Research Council, 3 vols., Washington, DC, National
Academy Press, 1982-85 Volume(issue)/page/year: 1,63,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human
DOSE/DURATION : 5 ug/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Behavioral - ataxia
Gastrointestinal - nausea or vomiting
REFERENCE :
85IVAW "Possible Long-Term Health Effects of Short-Term Exposure to Chemical
Agents," National Research Council, 3 vols., Washington, DC, National
Academy Press, 1982-85 Volume(issue)/page/year: 1,63,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 103 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal.
For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 1(3),3,1967

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
Volume(issue)/page/year: NX#11998

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 5 mmol/L
REFERENCE :
ACNSAX Activitas Nervosa Superior. (Avicenum, Malostranske nam. 28, Prague
1, Czechoslovakia) V.1- 1959- Volume(issue)/page/year: 17,252,1975

TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 30 mg/kg
REFERENCE :
ACNSAX Activitas Nervosa Superior. (Avicenum, Malostranske nam. 28, Prague
1, Czechoslovakia) V.1- 1959- Volume(issue)/page/year: 17,252,1975

TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 100 mg/kg
REFERENCE :
ACNSAX Activitas Nervosa Superior. (Avicenum, Malostranske nam. 28, Prague
1, Czechoslovakia) V.1- 1959- Volume(issue)/page/year: 17,252,1975

TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - hamster
DOSE/DURATION : 40 mg/kg/6H (Intermittent)
REFERENCE :
ACNSAX Activitas Nervosa Superior. (Avicenum, Malostranske nam. 28, Prague
1, Czechoslovakia) V.1- 1959- Volume(issue)/page/year: 17,253,1975

*** END OF RECORD ***
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Benzilic acid, 2-(1-ethyl-2-pyrrolidinyl)ethyl ester 102476-64-2
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Benzilic acid, hydrazide 13050-38-9
Benzilic acid, 4-isobutoxy-, 2-(diethylamino)ethylester, hydrochloride 13050-38-9
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Benzenesulfonamide,5-(1-hydroxy-2-((2-(2-methoxyphenoxy)ethyl)amino)ethyl)-2-methyl-, monohydrochloride 70958-86-0
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Benzilic acid, p-methyl-, 2-(diethylamino)ethyl ester 78200-30-3
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Benzilic acid, 2-(1-methyl-2-pyrrolidinyl)ethyl ester 13696-09-8
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Benzilic acid, 4-piperidino-2-butynyl ester,hydrochloride 95441-50-2
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Benzilic acid, 4-propoxy-, 2-(diethylamino)ethylester, hydrochloride 57258-61-4
Benzilic acid, 2-(1-propyl-2-pyrrolidinyl)ethyl ester 102762-74-3
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Benzilic acid, 3-quinuclidinyl ester 6581-06-2
Benzilic acid, 3-quinuclidinyl ester, (+-)- 6581-06-2
Benzilic acid, 1,2,2,6-tetramethyl-4-piperidinylester, hydrochloride 63991-47-9

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