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MSDS  : 11H-Benzo(5,6)cyclohepta(1,2-b)pyridine, 5,6-dihydro-11-(1-methyl-4-piperidylidene)-, dimaleate
CAS  : 3978-86-7
SYNONYMS  : * Azatadine dimaleate * Azatadine maleate * 6,11-Dihydro-11-(1-methyl-4-piperidylidene)5H-benzo(5,6)cyclohepta(1,2-b )pyridine dimaleate * Idulian * Optimine * Sch 10649 * Zadine
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : DE8025500
CHEMICAL NAME : 11H-Benzo(5,6)cyclohepta(1,2-b)pyridine,
5,6-dihydro-11-(1-methyl-4-piperidylidene)-,
dimaleate
CAS REGISTRY NUMBER : 3978-86-7
LAST UPDATED : 199604
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C20-H22-N2.2C4-H4-O4
MOLECULAR WEIGHT : 522.60
WISWESSER LINE NOTATION : T C676 DN&T&J B1- AT6N CUTJ &QV1U1VQ 2
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* Azatadine dimaleate
* Azatadine maleate
* 6,11-Dihydro-11-(1-methyl-4-piperidylidene)5H-benzo(5,6)cyclohepta(1,2-b
)pyridine dimaleate
* Idulian
* Optimine
* Sch 10649
* Zadine

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 286 mg/kg/24H-I
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
REFERENCE :
MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd.,
71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914-
Volume(issue)/page/year: 141,449,1984

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 440 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
18,185,1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 166 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year:
1,173,1975

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year:
1,173,1975

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 165 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70-
Volume(issue)/page/year: 4,264,1974

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 105 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year:
1,173,1975

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 178 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year:
1,173,1975

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Gastrointestinal - nausea or vomiting
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year:
1,79,1975

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 356 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70-
Volume(issue)/page/year: 4,264,1974

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8400 mg/kg/4W-I
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of endocrine pancreas
Liver - fatty liver degeneration
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year:
1,173,1975

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 27300 mg/kg/26W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Musculoskeletal - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year:
1,173,1975

*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
4H-Benzo(4,5)cyclohepta(1,2-b)furan-3-carboxamide,9,10-dihydro-N-(2-cyanoethyl)-N-(2-(4-morpholinyl)ethyl)-4-oxo-, monohydrochloride 83494-79-5
4H-Benzo(4,5)cyclohepta(1,2-b)furan-3-carboxamide,9,10-dihydro-N,N-diethyl-4-oxo- 83494-75-1
Benzo(3,4)cyclohepta(1,2-b)pyran-3(2H)-one,1,5,6,7-tetrahydro-9,10,11-trimethoxy- 49562-03-0
1H-Benzo(3,4)cyclohepta(1,2-b)pyrazine,2,3,4,4a,5,6,7,11b-octahydro-, (E)- 105124-55-8
Benzo(6,7)cyclohepta(1,2-c)pyrazole,2,3,3a,4,5,6-hexahydro-2-acetyl-8-methoxy-3-phenyl-,(+-)- 105124-55-8
Benzo(6,7)cyclohepta(1,2-c)pyrazole,2,3,3a,4,5,6-hexahydro-2-acetyl-8-methoxy-3-phenyl-,cis- 78431-43-3
Benzimidazole,6-chloro-4,5,7-tribromo-2-(trifluoromethyl)- 14689-60-2
3H-Benzo(6,7)cyclohepta(1,2-c)pyridazin-3-one,2,4,4a,5,6,7-hexahydro-9-amino- 103603-08-3
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine, 5-amino- 34222-89-4
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine, 5-amino-,hydrogen fumarate 63917-50-0
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine-5-carbamicacid, 10,11-dihydro-, ethyl ester 34144-47-3
5H-Benzo(5,6)cyclohepta(1,2-b)pyridine-8-carbonitrile, 6,11-dihydro-11-(1-methyl-4- piperidinylidene)- 143540-37-8
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine-5-carboxamide 31719-69-4
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine-5-carboxamide,10,11-dihydro- 33318-24-0
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine-5-carboxamide,10,11-dihydro-N-methyl- 34144-64-4
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine-5-carboxylicacid, 10,11-dihydro-, 2-(dimethylamino) ethyl ester,fumarate (1:1) 34137-62-7
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine-5-carboxylicacid, 10,11-dihydro-, 2-(dimethylamino) ethyl ester,maleate (1:1) 34137-60-5
Benzimidazole, 4-chloro-2-(trifluoromethyl)- 2338-31-0
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine-5-carboxylicacid, 10,11-dihydro-5-hydroxy-,2-(dimethylamino)ethyl ester 34144-31-5
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine-5-carboxylicacid, 10,11-dihydro-5-hydroxy-,(1-methyl-2-piperidyl)methyl ester 34144-32-6
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,7-chloro-5-((methylcarbamoyl)imino)- 36040-25-2
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,10,11-dihydro-5-amino-, oxalate (1:1) 34144-50-8
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,10,11-dihydro-7-chloro-5-((2-dimethylamino)ethoxy)-,hydrogen maleate 36040-20-7
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,10,11-dihydro-7-chloro-5-(8-methyl-8-azabicyclo(3.2.1)oct-5-yl)oxy-, hydrogen fumarate 63917-52-2
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,10,11-dihydro-7-chloro-5-(4-methylpiperazinyl)- 36040-23-0
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,10,11-dihydro-5-(2-(dimethylamino)ethoxy)- 17895-87-3
11H-Benzo(5,6)cyclohepta(1,2-C)pyridine,5,6-dihydro-11-(2-(dimethylamino)ethoxy)- 36040-35-4
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,10,11-dihydro-5-(2-(dimethylamino)ethoxy)-, hydrogenmaleate 17895-96-4
Benzimidazole, 5-chloro-2-(trifluoromethyl)- 656-49-5
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,10,11-dihydro-5-((2-dimethylamino)ethoxy)-7-methoxy-, hydrogen maleate, hydrate 63917-53-3
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,10,11-dihydro-7-methoxy-5-(8-azabicyclo(3.2.1)oct-3-yl)oxy- 63917-54-4
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,10,11-dihydro-7-methoxy-5-(N-methylpiperazinyl)- 36040-30-9
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,10,11-dihydro-5-(4-(m-methylbenzyl)-1-piperazinyl)-,maleate (1:1) 34137-59-2
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,10,11-dihydro-5-(4-methyl-1-piperazinyl)- 34144-68-8
11H-Benzo(5,6)cyclohepta(1,2-b)pyridine,5,6-dihydro-11-(1-methyl-4-piperidylidene)-,dimaleate 3978-86-7
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,10,11-dihydro-5-((1-methylpiperid-2-yl)methoxy)- 18374-06-6
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,10,11-dihydro-5-(3-alpha-tropanyl)-, hydrogen maleate 73698-56-3
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,10,11-dihydro-5-(3-alpha-tropanyloxy)- 19410-01-6
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,5-(2-(dimethylamino)ethoxy)- 17895-76-0
Benzimidazole,2-(p-cumenylthio)-1-(2-(diethylamino)ethyl)-,dipicrate 4929-62-8
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,5-(2-(dimethylamino)ethoxy)-, hydrogen maleate 17895-97-5
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,5-((1-methylpiperid-2-yl)methoxy)- 19410-15-2
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,5-(3-alpha-tropanyloxy)- 19410-02-7
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine,5-(3-alpha-tropanyloxy)-, hydrogen maleate 17929-04-3
5H-Benzo(4,5)cyclohepta(1,2-b)pyridin-5-ol 18374-08-8
5H-Benzo(4,5)cyclohepta(1,2-b)pyridin-5-ol,10,11-dihydro- 17895-95-3
11H-Benzo(5,6)cyclohepta(1,2-c)pyridin-11-ol,5,6-dihydro- 36040-33-2
5H-Benzo(4,5)cyclohepta(1,2-b)pyridin-5-ol,10,11-dihydro-5-ethynyl- 31721-91-2
5H-Benzo(4,5)cyclohepta(1,2-b)pyridin-5-ol,10,11-dihydro-5-ethynyl-, hydrochloride 31721-91-2
11H-Benzo(5,6)cyclohepta(1,2-c)pyridin-11-ol,5,6-dihydro-, hydrochloride 31771-05-8

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