*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DI3500000
CHEMICAL NAME : Benzonitrile, 2,6-dichloro-
CAS REGISTRY NUMBER : 1194-65-6
BEILSTEIN REFERENCE NO. : 1909167
REFERENCE : 4-09-00-01006 (Beilstein Handbook Reference)
LAST UPDATED : 199801
DATA ITEMS CITED : 17
MOLECULAR FORMULA : C7-H3-Cl2-N
MOLECULAR WEIGHT : 172.01
WISWESSER LINE NOTATION : NCR BG FG
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Casoron
* Casoron 133
* Code H 133
* Cyclomec
* 2,6-DBN
* DBN
* Decabane
* Dichlobenil
* 2,6-Dichlorbenzonitril
* 2,6-Dichlorobenzonitrile
* DU-Sprex
* H 133
* H 1313
* NIA 5996
* Niagara 5,996
* Norosac
* Prefix D
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2710 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year:
10,97,1965
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag
New York, Inc., 1971 Volume(issue)/page/year: -,145,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2056 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College
Science Pub., 1969 Volume(issue)/page/year: 5,73,1976
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >200 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - deviated nasal septum
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR
72203) V.1- 1979- Volume(issue)/page/year: 15,287,1994
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 360 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
Italy) V.8-43 1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 41,41,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 270 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Liver - other changes
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 6,261,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada,
171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,177,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 681 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,337,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag
New York, Inc., 1971 Volume(issue)/page/year: -,144,1971
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 gm/kg/5D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - deviated nasal septum
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR
72203) V.1- 1979- Volume(issue)/page/year: 15,287,1994
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 260 ug/kg/39D-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
AAATAP Annali dell'Accademia di Agricoltura di Torino. (Accademia de
Agricoltura di Torino, Via Andrea Doria 10, 10123 Turin, Italy) 1870-
Volume(issue)/page/year: 122,107,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 260 ug/kg/39D-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Tumorigenic - tumors at site of application
REFERENCE :
AAATAP Annali dell'Accademia di Agricoltura di Torino. (Accademia de
Agricoltura di Torino, Via Andrea Doria 10, 10123 Turin, Italy) 1870-
Volume(issue)/page/year: 122,107,1979
*** REVIEWS ***
TOXICOLOGY REVIEW
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.)
V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 24030
No. of Facilities: 40 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 200 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Benzonitrile,2-((4-((2-cyanoethyl)ethylamino)phenyl)azo)-5-nitro-
| 16889-10-4 |
Benzonitrile,4-cyanoethylsulfonyl-2,3,5,6-tetrachloro-
| 56916-60-0 |
Benzonitrile, 4-(decylsulfonyl)-2,3,5,6-tetrachloro-
| 56957-81-4 |
Benzonitrile,4-((2,4-diamino-5-pyrimidinyl)methyl)-2,6-dimethoxy-
| 55687-58-6 |
Benzonitrile, 3,5-dibromo-4-hydroxy-
| 1689-84-5 |
Benzonitrile, 3,5-dibromo-4-hydroxy-, potassium salt
| 2961-68-4 |
Benzonitrile, 3,5-dibromo-4-octanoyloxy-
| 1689-99-2 |
Benzoic acid, 2-phenylacetyl-
| 33148-55-9 |
Benzonitrile, 2,6-dichloro-
| 1194-65-6 |
Benzonitrile, 2,6-dichloro-3-hydroxy-
| 3336-34-3 |
Benzonitrile, 2,6-dichloro-4-hydroxy-
| 3336-19-4 |
Benzonitrile, 3,5-diethyl-4-hydroxy-
| 4910-03-6 |
Benzonitrile,4-(2,3-dihydro-2-(3-(4-(4-fluorophenyl)-1-piperazinyl)propyl)-5-methyl-3-o xo- 1H-pyrazol-1-yl)-
| 4910-03-6 |
Benzonitrile,4-(2,3-dihydro-5-methyl-2-(3-(4-(4-methyl-2-pyridinyl)-1-piperazinyl)propy l)-3- oxo-1H-pyrazol-1-yl)-,hydrochloride
| 104417-35-8 |
Benzonitrile,2-((3,4-dihydro-4-phenyl-(1)benzothieno(3,2-c)pyridin-2(1H)-yl)methyl)-
| 70547-17-0 |
Benzonitrile, 2,3-dihydroxy-5-(2-fluorobenzoyl)-
| 125629-17-6 |
Benzonitrile, 2,3-dihydroxy-5-nitro-
| 116314-86-4 |
Benzonitrile, 3,4-dihydroxy-5-nitro-
| 116313-86-1 |
Benzoic acid, 2-((phenylamino)carbonyl)-
| 4727-29-1 |
Benzonitrile, 3,5-diiodo-4-hydroxy-
| 1689-83-4 |
Benzonitrile, 3,5-diiodo-4-hydroxy-, lithium salt
| 2961-61-7 |
Benzonitrile, 3,5-diiodo-4-hydroxy-, sodium salt
| 2961-62-8 |
Benzonitrile, 2,3-dimethoxy-
| 5653-62-3 |
Benzonitrile, 2,6-dimethoxy-
| 16932-49-3 |
Benzonitrile, 3,5-dimethoxy-
| 19179-31-8 |
Benzonitrile, 3,4-dimethyl-
| 22884-95-3 |
Benzonitrile, 2,3-dimethyl-
| 5724-56-1 |
Benzonitrile, 2,4-dimethyl-
| 5724-56-1 |
Benzonitrile, 2,5-dimethyl-
| 13730-09-1 |
Benzoic acid, 4-(((phenylazo)phenylmethylene)amino)-,methyl ester
| 13730-09-1 |
Benzonitrile,2-((5-((2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)amino)- 2,4- dinitrophenyl)amino)-
| 142744-29-4 |
Benzonitrile,3-((2-((dimethylamino)methyl)phenyl)thio)-,(Z)-2-butenedioate (1:1)
| 139009-47-5 |
Benzonitrile, 3,5-dimethyl-4-hydroxy-
| 4198-90-7 |
Benzonitrile, 2,5-dimethyl-4-nitro-
| 73713-69-6 |
Benzonitrile,2-((5,5-dimethyl-3-oxo-1-cyclohexen-1-yl)amino)-
| 145657-28-9 |
Benzonitrile,4-(1,1-dimethyl-2-((3-phenoxyphenyl)methoxy)ethyl)-
| 80844-06-0 |
Benzonitrile, 3,5-dinitro-
| 4110-35-4 |
Benzonitrile,4-(6,8-dioxa-3-azabicyclo(3.2.1)oct-5-yl)-,(Z)-2-butenedioate (1:1)
| 84509-14-8 |
Benzonitrile, 3,5-dipropyl-4-hydroxy-
| 84509-14-8 |
Benzonitrile, 3,5-dipropyl-4-propoxy-
| 84509-14-8 |
Benzoic acid, 4-(((phenylazo)phenylmethylene)amino)-,((phenylazo)phenylmethylene)hydrazide
| 84509-14-8 |
Benzonitrile,4-ethoxyethylsulfonyl-2,3,5,6-tetrachloro-
| 56916-72-4 |
Benzonitrile,4-(6-ethoxy-1,2,4-triazolo(3,4-a)phthalazin-3-yl)-
| 87540-44-1 |
Benzonitrile, p-fluoro-
| 1194-02-1 |
Benzonitrile,4-(((1,4,5,6,7,8-hexahydro-4-phenyl-2-thioxo(1)benzothieno(2,3-d)pyrimidin- 3(2H)-yl)imino)methyl)-
| 136541-58-7 |
Benzonitrile, 4-hexylsulfonyl-2,3,5,6-tetrachloro-
| 56916-68-8 |
Benzonitrile, p-hydroxy-
| 767-00-0 |
Benzonitrile,p-(((17-beta-hydroxy-5-alpha-androstan-3-ylidene)amino)oxy)-
| 64584-57-2 |
Benzonitrile,2-(2-hydroxy-3-((2-(1H-indol-3-yl)-1,1-dimethylethyl)amino)propoxy)-, monohydrochloride
| 70369-47-0 |
Benzonitrile, 4-hydroxy-3-iodo-5-nitro-
| 1689-89-0 |
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