RTECS NUMBER : DI8225000
CHEMICAL NAME : Benzo(c)phenanthrene
CAS REGISTRY NUMBER : 195-19-7
BEILSTEIN REFERENCE NO. : 1909296
REFERENCE : 4-05-00-02552 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C18-H12
MOLECULAR WEIGHT : 228.30
WISWESSER LINE NOTATION : L C6 B666J
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* 3,4-Benzophenanthrene
* 3,4-Benzphenanthrene
* Tetrahelicene
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 940 mg/kg/39W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
PRLBA4 Proceedings of the Royal Society of London, Series B: Biological
Sciences. (Royal Soc., 6 Carlton House Terrace, London SW1Y 5AG, UK) V.76-
1905- Volume(issue)/page/year: 117,318,1935
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1220 mg/kg/51W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
PRLBA4 Proceedings of the Royal Society of London, Series B: Biological
Sciences. (Royal Soc., 6 Carlton House Terrace, London SW1Y 5AG, UK) V.76-
1905- Volume(issue)/page/year: 129,439,1940
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1270 mg/kg/53W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
PRLBA4 Proceedings of the Royal Society of London, Series B: Biological
Sciences. (Royal Soc., 6 Carlton House Terrace, London SW1Y 5AG, UK) V.76-
1905- Volume(issue)/page/year: 123,343,1937
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 25 nmol/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
40,2876,1980
TYPE OF TEST : DNA adduct
TEST SYSTEM : Human Mammary gland
DOSE/DURATION : 10 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 17,2237,1996
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 240 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 371,123,1996
TYPE OF TEST : DNA adduct
ROUTE OF EXPOSURE : Administration onto the skin
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 80 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 17,2237,1996
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 32,205,1983
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 32,205,1983
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: Pc,4,1972
*** STATUS IN U.S. ***
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
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