*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DK8187000
CHEMICAL NAME : 2H-1,2,4-Benzothiadiazine,
7-chloro-3-(4-methyl-1-piperazinyl)-, 1,1-dioxide
CAS REGISTRY NUMBER : 59943-31-6
LAST UPDATED : 199310
DATA ITEMS CITED : 8
MOLECULAR FORMULA : C12-H15-Cl-N4-O2-S
MOLECULAR WEIGHT : 314.82
WISWESSER LINE NOTATION : T66 BSWN EMJ IG D- AT6N DNTJ D1
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* 7-Chloro-3-(4-methyl-1-piperazinyl)-4H-1,2,4-benzothiadiazine-1,1-dioxide
* DU-717
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - tremor
Lungs, Thorax, or Respiration - other changes
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 11,294,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Behavioral - tremor
Lungs, Thorax, or Respiration - other changes
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 11,294,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 551 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 11,294,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - tremor
Lungs, Thorax, or Respiration - other changes
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 11,294,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >2412 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Lungs, Thorax, or Respiration - other changes
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 11,294,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 242 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 11,294,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 11,294,1980
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 499 gm/kg/26W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria
Endocrine - changes in thymus weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 11,294,1980
*** END OF RECORD ***
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| ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| | NAME | CAS |
|
o-Benzoquinone
| 583-63-1 |
|
p-Benzoquinone,2,5-bis((4-(diethylamino)butyl)amino)-
| 102944-92-3 |
|
1,2,4-Benzothiadiazepine,2,5-dihydro-2-methyl-3-(p-nitrophenyl)-, 1,1-dioxide
| 40431-27-4 |
|
1,2,4-Benzothiadiazepine,2,5-dihydro-2-methyl-3-phenyl-, 1,1-dioxide
| 40431-23-0 |
|
1,2,4-Benzothiadiazepine,2,5-dihydro-2-methyl-3-propyl-, 1,1-dioxide
| 46781-71-9 |
|
2H-1,2,4-Benzothiadiazin-3-amine, 1,1-dioxide
| 16288-74-7 |
|
1H-2,1,4-Benzothiadiazine-3-carbamic acid, methylester
| 33082-92-7 |
|
2H-1,2,4-Benzothiadiazine-3-carboxamide,N-(3-chlorophenyl)-, 1,1-dioxide
| 57864-87-6 |
|
2H-1,2,4-Benzothiadiazine-3-carboxylic acid,7-(aminosulfonyl)-6-chloro-3,4-dihydro- 2-methyl-,methyl ester, 1,1-dioxide
| 42583-55-1 |
|
2H-1,2,4-Benzothiadiazine-3-carboxylic acid,2-((4-(aminosulfonyl)phenyl)sulfonyl)hydrazide,1,1-dioxide
| 57864-99-0 |
|
2H-1,2,4-Benzothiadiazine-3-carboxylic acid,3,4-dihydro-7-sulfamoyl-6-(trifluoromethyl)-,1,1-dioxide
| 393-21-5 |
|
2H-1,2,4-Benzothiadiazine-3-carboxylic acid,3,4-dihydro-7-sulfamoyl-6-(trifluoromethyl)-,1,1-dioxide, compd. with2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy) ethanol (2:1)
| 393-21-5 |
|
p-Benzoquinone,2,5-bis((2-(diethylamino)ethyl)amino)-
| 23419-59-2 |
|
2H-1,2,4-Benzothiadiazine-3-carboxylic acid,1,1-dioxide
| 57864-78-5 |
|
2H-1,2,4-Benzothiadiazine-3-carboxylic acid,2-((4-methylphenyl)sulfonyl)hydrazide, 1,1-dioxide
| 57864-94-5 |
|
4H-1,2,4-Benzothiadiazine, 3-chloro-4-ethyl-,1,1-dioxide
| 107089-77-0 |
|
2H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-,1,1-dioxide
| 364-98-7 |
|
4H-1,2,4-Benzothiadiazine, 3-chloro-4-methyl-,1,1-dioxide
| 107089-76-9 |
|
2H-1,2,4-Benzothiadiazine,7-chloro-3-(4-methyl-1-piperazinyl)-, 1,1-dioxide
| 59943-31-6 |
|
4H-1,2,4-Benzothiadiazine, 3-chloro-4-phenyl-,1,1-dioxide
| 107089-78-1 |
|
2H-1,2,4-Benzothiadiazine, 6,7-dichloro-, 1,1-dioxide
| 359-87-5 |
|
2H-1,2,4-Benzothiadiazine, 6,7-dichloro-3-methyl-,1,1-dioxide
| 364-96-5 |
|
2H-1,2,4-Benzothiadiazine,3,4-dihydro-6-chloro-3-(alpha-methylbenzyl)-7-sulfamoyl-, 1,1-dioxide
| 1824-52-8 |
|
p-Benzoquinone,2,5-bis((5-(diethylamino)pentyl)amino)-
| 102808-97-9 |
|
2H-1,2,4-Benzothiadiazine, 3,4-dihydro-6,7-dichloro-,1,1-dioxide
| 359-86-4 |
|
2H-1,2,4-Benzothiadiazine,3,4-dihydro-6,7-dichloro-3-methyl-, 1,1-dioxide
| 446-62-8 |
|
2H-1,2,4-Benzothiadiazine, 3,4-dihydro-, 1,1-dioxide
| 359-84-2 |
|
4H-1,2,4-Benzothiadiazine,3-(2,3-dihydro-3,3,5-trimethyl-1H-pyrazol-1-yl)-4-ethyl-, S,S-dioxide
| 107089-89-4 |
|
4H-1,2,4-Benzothiadiazine,3-(2,3-dihydro-3,3,5-trimethyl-1H-pyrazol-1-yl)-4-methyl-, S,S-dioxide
| 107089-88-3 |
|
4H-1,2,4-Benzothiadiazine,3-(2,3-dihydro-3,3,5-trimethyl-1H-pyrazol-1-yl)-4-phenyl-, S,S-dioxide
| 107089-90-7 |
|
4H-1,2,4-Benzothiadiazine,3-(3,5-dimethyl-1H-pyrazol-1-yl)-4-ethyl-,1,1-dioxide
| 107089-83-8 |
|
4H-1,2,4-Benzothiadiazine,3-(3,5-dimethyl-1H-pyrazol-1-yl)-4-methyl-,1,1-dioxide
| 107089-82-7 |
|
4H-1,2,4-Benzothiadiazine,3-(3,5-dimethyl-1H-pyrazol-1-yl)-4-phenyl-,1,1-dioxide
| 107089-84-9 |
|
2H-1,2,4-Benzothiadiazine, 1,1-dioxide
| 359-85-3 |
|
p-Benzoquinone,2,5-bis((3-(diethylamino)propyl)amino)-
| 1245-79-0 |
|
|