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MSDS  : 1H-Benzotriazole
CAS  : 95-14-7
SYNONYMS  : * 1,2,-Aminozophenylene * Azimidobenzene * Aziminobenzene * Benzene azimide * Benzisotriazole * 1,2,3-Benzotriazole * Benztriazole * Cobratec #99 * 2,3-Diazaindole * NCI-C03521 * NSC-3058 * 1,2,3-Triazaindene * U-6233
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : DM1225000
CHEMICAL NAME : 1H-Benzotriazole
CAS REGISTRY NUMBER : 95-14-7
OTHER CAS REGISTRY NOS. : 25377-81-5
27556-51-0
BEILSTEIN REFERENCE NO. : 0112133
REFERENCE : 4-26-00-00093 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 21
MOLECULAR FORMULA : C6-H5-N3
MOLECULAR WEIGHT : 119.14
WISWESSER LINE NOTATION : T56 BMNNJ
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* 1,2,-Aminozophenylene
* Azimidobenzene
* Aziminobenzene
* Benzene azimide
* Benzisotriazole
* 1,2,3-Benzotriazole
* Benztriazole
* Cobratec #99
* 2,3-Diazaindole
* NCI-C03521
* NSC-3058
* 1,2,3-Triazaindene
* U-6233

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 560 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0516797

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1910 mg/m3/3H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in trachea
or bronchi
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520637

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0516745

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 615 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A067-313

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 41,708,1978

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 238 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 105,486,1952

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520182

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 46(11),70,1981

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 109 mg/kg/26W-I
TOXIC EFFECTS :
Endocrine - other changes
Blood - normocytic anemia
Blood - leukopenia
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 46(11),70,1981

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 220 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Brain and Coverings - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-88,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 770 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Lungs, Thorax, or Respiration - bronchiogenic carcinoma
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-88,1978

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 ug/plate
REFERENCE :
IAPUDO IARC Publications. (WHO Publications Centre USA, 49 Sheridan Ave.,
Albany, NY 12210) No.27- 1979- Volume(issue)/page/year: 27,283,1980

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 33300 ng/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7(Suppl
5),1,1985

TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - rat Embryo
DOSE/DURATION : 94 ug/plate
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
Volume(issue)/page/year: 1,190,1981

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 82113
No. of Facilities: 1661 (estimated)
No. of Industries: 23
No. of Occupations: 33
No. of Employees: 5550 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 82113
No. of Facilities: 17143 (estimated)
No. of Industries: 144
No. of Occupations: 107
No. of Employees: 279549 (estimated)
No. of Female Employees: 40869 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NCI Carcinogenesis Bioassay (feed);inadequate studies:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-88,78


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
4H-1-Benzothiopyran-4-one,2,3-dihydro-3-((2-methoxyphenyl)methylene)-,1,1-dioxide, (Z)- 132794-02-6
4H,5H-(1)Benzothiopyrano(4,3-b)pyran-3-carbonitrile,2-amino-9-chloro-4-phenyl- 135521-74-3
1,2,3-Benzotriazin-4(3H)-one,3-(1-methyl-1H-pyrazol-5-yl)- 131073-48-8
1,2,3-Benzotriazin-4(3H)-one,3-(1-phenyl-1H-pyrazol-5-yl)- 131073-49-9
1H-Benzotriazole 95-14-7
1H-Benzotriazole-1-acetic acid, ethyl ester 95-14-7
1H-Benzotriazole,1-(2-(N-benzyl-N-(2-chloroethyl)amino)ethyl)-,hydrochloride 69780-75-2
1H-Benzotriazole-5-carboxamide,6-methoxy-N-((1-(2-propenyl)-2-pyrrolidinyl)methyl)- 59338-93-1
1H-Benzotriazole, 1-(2-chloroethyl)- 59338-93-1
1H-Benzotriazole,1-(2-(N-(2-chloroethyl)-N-ethylamino)ethyl)-,hydrochloride 69766-31-0
1H-Benzotriazole, compd. with cyclohexanamine (11) 90683-27-5
1H-Benzotriazole,1-(cyclohexylcarbonyl)-5-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)- 85634-51-1
4H,5H-(1)Benzothiopyrano(4,3-b)pyran-3-carbonitrile,2-amino-4-(3,4-dimethoxyphenyl)- 115091-78-6
1H-Benzotriazole-1-ethanamine, N,N-dimethyl-3-oxide,2-hydroxy-1,2,3-propanetricarboxylate 115091-78-6
1H-Benzotriazole-1-ethanol, 5-ethoxy- 94120-18-0
1H-Benzotriazole-1-ethanol, 5-ethoxy-6-nitro- 94120-25-9
1H-Benzotriazole-1-ethanol, 5-methoxy-6-nitro- 94120-22-6
1H-Benzotriazole, 1-ethenyl-, polymer with(Z)-diethyl-2-butenedioate 107845-71-6
1H-Benzotriazole, 1-ethyl- 16584-05-7
1H-Benzotriazole, 1-hydroxy-, ammonium salt 63307-62-0
1H-Benzotriazole, 1-hydroxy-, hydrate 2592-95-2
1H-Benzotriazole, methyl- 29385-43-1
1H-Benzotriazole, 1-methyl- 13351-73-0
4H,5H-(1)Benzothiopyrano(4,3-b)pyran-3-carbonitrile,2-amino-4-(4-hydroxy-3-methoxyphenyl)- 135521-72-1
1H-Benzotriazole, 5-methyl- 136-85-6
1H-Benzotriazole, 1-((3-methylpiperidino)methyl)-,hydrochloride 19212-98-7
1H-Benzotriazole, 1-((4-methylpiperidino)methyl)-,hydrochloride 19212-99-8
1H-Benzotriazole, 1-(morpholinomethyl)-,hydrochloride 19212-99-8
1H-Benzotriazole, 5-nitro- 2338-12-7
1H-Benzotriazole,1-(5-phenylthieno(2,3-d)isothiazol-3-yl)-, S(sup1),S(sup 1)-dioxide 113412-71-8
1H-Benzotriazole, 4-(1-piperazinyl)-, dihydrochloride 84807-07-8
1H-Benzotriazole-1-propanamine, N,N-dimethyl-3-oxide,2-hydroxy-1,2,3-propanetricarboxylate 84807-07-8
1H-Benzotriazole, 1-(1-pyrrolidinylmethyl)-,hydrochloride 19213-37-7
1H-Benzotriazole, 1-thieno(2,3-d)isothiazol-3-yl-,S(sup 1),S(sup 1)-dioxide 119120-83-1
4H,5H-(1)Benzothiopyrano(4,3-b)pyran-3-carbonitrile,2-amino-4-(2-methoxyphenyl)- 115091-76-4
1H-Benzotriazole, 1-thieno(3,4-d)isothiazol-3-yl-,S(sup 1),S(sup 1)-dioxide 113387-65-8

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