*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : EK2625000
CHEMICAL NAME : 2,3-Butanedione
CAS REGISTRY NUMBER : 431-03-8
BEILSTEIN REFERENCE NO. : 0605398
REFERENCE : 4-01-00-03644 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C4-H6-O2
MOLECULAR WEIGHT : 86.10
WISWESSER LINE NOTATION : 1VV1
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Biacetyl
* 2,3-Butadione
* Diacetyl
* 2,3-Diketobutane
* Dimethyl diketone
* Dimethylglyoxal
* Glyoxal, dimethyl-
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Moderate
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,765,1979
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1580 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
Vascular - regional or general arteriolar or venous dilation
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 7,571,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,765,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 990 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Behavioral - coma
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 48600 mg/kg/90D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in adrenal weight
Blood - pigmented or nucleated red blood cells
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 7,571,1969
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 1 mg/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 67,367,1979
TYPE OF TEST : Unscheduled DNA synthesis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 1500 mg/kg
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
Volume(issue)/page/year: 76,809,1985
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84595
No. of Facilities: 126 (estimated)
No. of Industries: 3
No. of Occupations: 6
No. of Employees: 1503 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84595
No. of Facilities: 185 (estimated)
No. of Industries: 3
No. of Occupations: 13
No. of Employees: 3438 (estimated)
No. of Female Employees: 1628 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP Carcinogenesis studies; selected, October 1997
*** END OF RECORD ***
|
|
|
| ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| | NAME | CAS |
|
1,4-Butanediol, 1,1,4,4-tetraphenyl-
| 63469-15-8 |
|
1,3-Butanediol,1-(2-thienyl)-4,4,4-trifluoro-3-trifluoromethyl-
| 34848-26-5 |
|
2,3-Butanediol, 1-(p-tolyloxy)-
| 34848-26-5 |
|
2,3-Butanediol, 1,1,1-trichloro-, erythro-
| 32817-82-6 |
|
2,3-Butanediol, 1,1,1-trichloro-, threo-
| 32817-81-5 |
|
1,3-Butanediol,4,4,4-trifluoro-3-(trifluoromethyl)-1-(alpha,alpha,alpha-trifluoro-m-tolyl )-
| 34848-23-2 |
|
2,3-Butanedione
| 431-03-8 |
|
1,3-Butanedione, 1-(2-benzothiazolyl)-,3-(phenylhydrazone)
| 86319-91-7 |
|
2,3-Butanedione, bis(bis(2-chloroethyl)hydrazone)
| 91556-40-0 |
|
2,3-Butanedione, bis(2-chloroethyl)hydrazone
| 94629-31-9 |
|
|