RTECS NUMBER : EK1225000
CHEMICAL NAME : 1,3-Butanediol, cyclic sulfite
CAS REGISTRY NUMBER : 4426-51-1
BEILSTEIN REFERENCE NO. : 1237514
REFERENCE : 4-01-00-02510 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 7
MOLECULAR FORMULA : C4-H8-O3-S
MOLECULAR WEIGHT : 136.18
WISWESSER LINE NOTATION : T6OSOTJ BO D1
SYNONYMS/TRADE NAMES :
* 1,3,2-Dioxathiane, 4-methyl-, 2-oxide
* 4-Methyl-trimethylene sulfite
* NSC-60195
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NCISS* Progress Report Submitted to the National Cancer Institute by South
Shore Analytical and Research Laboratory. Volume(issue)/page/year:
-,57,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NCISS* Progress Report Submitted to the National Cancer Institute by South
Shore Analytical and Research Laboratory. Volume(issue)/page/year:
-,57,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NCISS* Progress Report Submitted to the National Cancer Institute by South
Shore Analytical and Research Laboratory. Volume(issue)/page/year:
-,57,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NCISS* Progress Report Submitted to the National Cancer Institute by South
Shore Analytical and Research Laboratory. Volume(issue)/page/year:
-,57,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 175 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NCISS* Progress Report Submitted to the National Cancer Institute by South
Shore Analytical and Research Laboratory. Volume(issue)/page/year:
-,57,1964
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 780 mg/kg/13D-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Kidney, Ureter, Bladder - hematuria
Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
NCISS* Progress Report Submitted to the National Cancer Institute by South
Shore Analytical and Research Laboratory. Volume(issue)/page/year:
-,57,1964
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 560 mg/kg/14D-I
TOXIC EFFECTS :
Behavioral - ataxia
Gastrointestinal - hypermotility, diarrhea
Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
NCISS* Progress Report Submitted to the National Cancer Institute by South
Shore Analytical and Research Laboratory. Volume(issue)/page/year:
-,57,1964
*** END OF RECORD ***
ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP