*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : EJ4091000
CHEMICAL NAME : 1-Butanamine, N-methyl-4-(2-(phenylmethyl)phenoxy)-,
hydrochloride
CAS REGISTRY NUMBER : 62232-46-6
LAST UPDATED : 199409
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C18-H23-N-O.Cl-H
MOLECULAR WEIGHT : 305.88
WISWESSER LINE NOTATION : 1M4OR B1R &GH
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Alnert
* 2-Benzyl-1-(4-(methylamino)butoxy)benzene hydrochloride
* 4-(o-Benzylphenoxy)-N-methylbutylamine hydrochloride
* Bifemelane hydrochloride
* Butylamine, N-methyl-4-(o-benzylphenoxy)-, hydrochloride
* Celeport
* E-0687
* MCI-2016
* 2-(4-Methylaminobutoxy)diphenylmethane hydrochloride
* N-Methyl-4-(2-(phenylmethyl)phenoxy)-1-butanamine hydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1080 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 31,1278,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 130 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 31,1278,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 513 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 31,587,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 40400 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 31,587,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press
Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929-
Volume(issue)/page/year: 53,1307,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 105 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 16,1181,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 313 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 31,587,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 35300 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 31,587,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 151 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - food intake (animal)
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
SHNSAS Shinryo to Shinyaku. Medical Consultation and New Remedies. (Iji
Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan) V.1- 1964-
Volume(issue)/page/year: 23,43,1986
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 11375 mg/kg/13W-C
TOXIC EFFECTS :
Liver - fatty liver degeneration
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 31,587,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 9100 mg/kg/52W-C
TOXIC EFFECTS :
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - other changes in urine composition
Blood - changes in erythrocyte (RBC) count
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 31,601,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 24 gm/kg/52W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - changes in leukocyte (WBC) count
Related to Chronic Data - death
REFERENCE :
SHNSAS Shinryo to Shinyaku. Medical Consultation and New Remedies. (Iji
Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan) V.1- 1964-
Volume(issue)/page/year: 23,57,1986
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Biuret, 1-benzyl-
| 66903-24-0 |
Butanamide,2-((4-methoxyphenyl)hydrazono)-N-methyl-3-oxo-
| 137521-50-7 |
Butanamide, 3-methyl-
| 541-46-8 |
Butanamide,N-(1-(2-(2-methyl-1H-indol-3-yl)ethyl)-4-piperidinyl)-, hydrate
| 35699-02-6 |
Butanamide,N-methyl-2-((3-methylphenyl)hydrazono)-3-oxo-
| 137521-48-3 |
Butanamide,N-methyl-2-((4-methylphenyl)hydrazono)-3-oxo-
| 137521-49-4 |
Butanamide,N-methyl-2-((2-nitrophenyl)hydrazono)-3-oxo-
| 137521-57-4 |
Butanamide,N-methyl-2-((4-nitrophenyl)hydrazono)-3-oxo-
| 137521-58-5 |
Butanamide, N-methyl-3-oxo-2-(phenylhydrazono)-
| 137521-47-2 |
Butanamide, 3-methyl-N-(4-oxo-4-(propylamino)butyl)-
| 82024-01-9 |
Butanamide,N-(1-methyl-2-(1-piperidinyl)ethyl)-N-2-pyridinyl-
| 54153-14-9 |
Biuret, 1,1'-(4,4'-biphenylene)bis(2,4-dithio-
| 54153-14-9 |
Butanamide, N-(4-(4-morpholinyl)-4-oxobutyl)-
| 82023-72-1 |
Butanamide,N-(((2-(6-nitro-1H-benzimidazol-1-yl)ethyl)amino)carbonyl)-
| 66473-21-0 |
Butanamide, 4-((1-oxobutyl)amino)-N-(phenylmethyl)-
| 82023-83-4 |
Butanamide, 4-((1-oxobutyl)amino)-N-propyl-
| 82023-85-6 |
Butanamide,N-(4-((4-((1-oxopropyl)amino)phenyl)sulfonyl)phenyl)-
| 82023-85-6 |
Butanamide, 2-phenyl-N-(2-(1-pyrrolidinyl)ethyl)-,monohydrochloride
| 63207-76-1 |
Butanamide, N-(1,2,3,4-tetrahydro-9-acridinyl)-
| 123792-69-8 |
Butanamide,N-((4-((3-(trifluoromethyl)phenyl)amino)-3-pyridinyl)sulfonyl)-
| 52157-92-3 |
1-Butanamine,N-butyl-N-(3-(4-(8-methylimidazo(1,2-a)pyridin-2-yl)phenoxy)propyl)-, monohydrochloride
| 52157-92-3 |
1-Butanamine, 4-((1,1'-biphenyl)-2-yloxy)-,hydrochloride
| 62232-78-4 |
Biuret, 1,5-bis(p-methoxyphenyl)-2,4-dithio-
| 57633-37-1 |
1-Butanamine, 4-((1,1'-biphenyl)-2-yloxy)-N-methyl-,hydrochloride
| 62232-79-5 |
1-Butanamine,N,N-bis(1-methylethyl)-4-((1,3-dihydro-6-methyl-4-(phenylmethyl) furo(3,4-c)pyridin-7-yl)oxy)-,dihydrochloride
| 68524-44-7 |
1-Butanamine,N-butyl-N-(2-((1,4-diphenyl-1H-pyrazol-3-yl)oxy)ethyl)-, monomethanesulfonate
| 62832-67-1 |
1-Butanamine, N-butyl-N-nitroso-
| 924-16-3 |
1-Butanamine,4-(2-(2-(2-chlorophenyl)ethyl)phenoxy)-N,N-dimethyl-,hydrochloride
| 72284-46-9 |
1-Butanamine,4-((1,3-dihydro-6-methyl-4-(phenylmethyl)furo(3,4-c)pyridin-7-yl)oxy)-N- (1-methylethyl)-, dihydrochloride
| 68484-35-5 |
1-Butanamine,4-((1,3-dihydro-6-methyl-4-(phenylmethyl)furo(3,4-c)pyridin-7-yl)oxy)-N- (1-methylpropyl)-,dihydrochloride
| 68484-48-0 |
1-Butanamine,4-((1,3-dihydro-6-methyl-4-(phenylmethyl)furo(3,4-c)pyridin-7-yl)oxy)-N- (1,1-dimethylethyl)-,dihydrochloride
| 68484-49-1 |
1-Butanamine,4-((1,3-dihydro-6-methyl-4-(phenylmethyl)furo(3,4-c)pyridin-7-yl)oxy)-N-et hyl-, dihydrochloride
| 68484-46-8 |
2-Butanamine, N-(1,1-dimethylethyl)-2-methyl-,hydrochloride
| 2085-65-6 |
Biuret, 1-(p-butoxyphenyl)-2,4-dithio-
| 2085-65-6 |
1-Butanamine,N,N-dimethyl-4-(2-(2-(2-methoxyphenyl)ethyl)phenoxy)-, hydrochloride
| 72279-03-9 |
1-Butanamine,N,N-dimethyl-4-(2-(2-(3-methoxyphenyl)ethyl)phenoxy)-, hydrochloride
| 72279-04-0 |
1-Butanamine,N,N-dimethyl-4-(2-methyl-6-(phenylmethyl)phenoxy)-,hydrochloride
| 67346-18-3 |
1-Butanamine,N,N-dimethyl-4-(4-methyl-2-(phenylmethyl)phenoxy)-,hydrochloride
| 67346-20-7 |
1-Butanamine,N,N-dimethyl-4-(2-(2-phenylethyl)phenoxy)-,hydrochloride
| 72284-49-2 |
1-Butanamine,N,N-dimethyl-4-(2-(phenylthio)phenoxy)-,hydrochloride
| 62232-58-0 |
1-Butanamine,N-(2-((1,4-diphenyl-1H-pyrazol-3-yl)oxy)ethyl)-,monomethanesulfonate
| 62832-85-3 |
1-Butanamine,N-(3-((1,4-diphenyl-1H-pyrazol-3-yl)oxy)propyl)-,monohydrochloride
| 62833-01-6 |
1-Butanamine,4-(2-(2-(4-fluorophenyl)ethyl)phenoxy)-N,N-dimethyl-,hydrochloride
| 72279-35-7 |
1-Butanamine,4-(2-((2-methoxyphenyl)methyl)phenoxy)-N-methyl-,hydrochloride
| 67346-31-0 |
Biuret, 1-butyl-2,4-dithio-
| 98275-27-5 |
1-Butanamine,N-methyl-4-(2-methyl-6-(phenylmethyl)phenoxy)-,hydrochloride
| 67346-17-2 |
1-Butanamine, N-methyl-4-(2-(phenylmethyl)phenoxy)-,hydrochloride
| 62232-46-6 |
1-Butanamine, N-methyl-4-(2-(phenylthio)phenoxy)-,hydrochloride
| 62232-61-5 |
2-Butanamine, N-methyl-N-2-propynyl-, ethanedioate(1:1)
| 143347-29-9 |
1-Butanamine, N-methyl-N-2-propynyl-, hydrochloride
| 143347-17-5 |
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