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MSDS  : 1-Butanone, 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-, hydrochloride
CAS  : 35543-24-9
SYNONYMS  : * A-48257 * Bufedil * Buflomedil hydrochloride * Chlorhydrate de (trimethoxy-2-4-6) phenyl-(pyrrolidine-3) propylacetone * Fonzylane * LL 1656 * Loftyl * 4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone hydrochloride * 4-(1-Pyrrolidyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone hydrochloride
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : EL9900000
CHEMICAL NAME : 1-Butanone,
4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-,
hydrochloride
CAS REGISTRY NUMBER : 35543-24-9
LAST UPDATED : 199709
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C17-H25-N-O4.Cl-H
MOLECULAR WEIGHT : 343.89
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* A-48257
* Bufedil
* Buflomedil hydrochloride
* Chlorhydrate de (trimethoxy-2-4-6) phenyl-(pyrrolidine-3) propylacetone
* Fonzylane
* LL 1656
* Loftyl
* 4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone hydrochloride
* 4-(1-Pyrrolidyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone hydrochloride

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 55 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
REFERENCE :
ICMED9 Intensive Care Medicine. (Springer-Verlag New York, Inc., Service
Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1977-
Volume(issue)/page/year: 20,219,1994

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 60 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
REFERENCE :
ICMED9 Intensive Care Medicine. (Springer-Verlag New York, Inc., Service
Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1977-
Volume(issue)/page/year: 22,57,1996

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 216 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
Cardiac - other changes
REFERENCE :
ICMED9 Intensive Care Medicine. (Springer-Verlag New York, Inc., Service
Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1977-
Volume(issue)/page/year: 22,57,1996

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 410 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 22,401,1988

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 796 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 22,401,1988

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 58500 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 22,401,1988

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 275 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - convulsions or effect on seizure threshold
Kidney, Ureter, Bladder - hematuria
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 30,207,1975

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 286 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 22,401,1988

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 40 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 22,401,1988

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - convulsions or effect on seizure threshold
Kidney, Ureter, Bladder - hematuria
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 30,207,1975

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - other changes
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 22,425,1988

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Cardiac - other changes
Lungs, Thorax, or Respiration - other changes
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 30,207,1975

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2730 mg/kg/91D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - changes in testicular weight
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 5,401,1982

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1500 mg/kg
SEX/DURATION : female 17-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 22,473,1988

*** END OF RECORD ***
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NAMECAS
1-Butanone,1-(4-(3-(4-phenyl-1-piperazinyl)propoxy)phenyl)- 65976-20-7
1-Butanone, 1-phenyl-2-(propylamino)-, hydrochloride 18267-91-9
2-Butanone, 4-phenyl-, 3-thiosemicarbazone 25687-87-0
1-Butanone, 4-piperidino-1-(2-thiazolyl)-,hydrobromide 33524-05-9
Butane, 1,1'-sulfinylbis- 2168-93-6
1-Butanone, 4-piperidino-1-(3-thienyl)-, hydrobromide 31634-18-1
1-Butanone, 4-piperidino-1-(3-thienyl)-,hydrochloride 31634-33-0
1-Butanone, 4-piperidino-1-(3-thienyl)-, oxime,hydrochloride 31634-40-9
1-Butanone, 1-(4-pyridyl)- 1701-71-9
1-Butanone, 1-(4-pyridyl)-4-(1-pyrrolidinyl)-,citrate 59921-92-5
1-Butanone, 4-(1-pyrrolidinyl)-1-(2-thiazolyl)-,hydrobromide 33524-04-8
1-Butanone, 4-(1-pyrrolidinyl)-1-(3-thienyl)-,hydrobromide 31634-17-0
1-Butanone, 4-(1-pyrrolidinyl)-1-(3-thienyl)-, oxime,hydrochloride 31634-38-5
1-Butanone,4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)- 55837-25-7
1-Butanone,4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-,hydrochloride 35543-24-9
1-Butanesulfonamide 3144-04-5
2-Butanone, semicarbazone 624-46-4
2-Butanone, 4-(tetrahydro-2-furyl)- 624-46-4
1-Butanone,1,1'-(9H-thioxanthene-2,7-diyl)bis(4-(diethylamino)-,dihydrochloride 37771-04-3
2-Butanone, 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)- 31499-72-6
Butanoyl chloride, 4-chloro- 4635-59-0
delta-Butazolidine 8054-70-4
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Butea monosperma (lam.) Kuntze, flower extract 93333-82-5
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Butanesulfonamide,N-(4-(acridin-9-ylamino)-3-methoxyphenyl)-,methanesulfonate 59988-05-5
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3-Butenamide,N,N-bis(2-hydroxyethyl)-3-methyl-4-phenyl- 58458-54-1
2-Butenamide,N-(4-((4-(acetylamino)phenyl)sulfonyl)phenyl)- 58458-54-1
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2-Butenamide,N-(2-(4-((3-cyclohexyl-2-imino-1-imidazolidinyl)sulfonyl)phenyl)ethyl)-, hydrochloride, (E)- 126681-81-0
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3-Butenamide, N-(2-hydroxyethyl)-3-methyl-4-phenyl- 58458-52-9
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