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MSDS  : Acetic acid, (2-(octahydro-5-hydroxy-4-(3-hydroxy-5-methyl-1-nonen yl)-2-pentalenyl)etho xy)-, methyl ester, (2R-(2-alpha,3a-alpha,4-alpha(1E,3S*,5S*),5-beta,6a-a lpha))-
CAS  : 139403-31-9
SYNONYMS  : * Pimilprost * SM 10902
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : AJ1393333
CHEMICAL NAME : Acetic acid,
(2-(octahydro-5-hydroxy-4-(3-hydroxy-5-methyl-1-nonen
yl)-2-pentalenyl)etho xy)-, methyl ester,
(2R-(2-alpha,3a-alpha,4-alpha(1E,3S*,5S*),5-beta,6a-a
lpha))-
CAS REGISTRY NUMBER : 139403-31-9
LAST UPDATED : 199807
DATA ITEMS CITED : 9
MOLECULAR FORMULA : C23-H40-O5
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Pimilprost
* SM 10902

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >1010 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 30,1179,1996

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 53 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 30,1179,1996

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 23 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 30,1179,1996

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 30 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Endocrine - changes in adrenal weight
Endocrine - changes in thymus weight
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 30,1179,1996

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 9100 ug/kg/26W-I
TOXIC EFFECTS :
Blood - macrocytosis
Blood - changes in platelet count
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 30,1273,1996

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3 mg/kg/30D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 30,1191,1996

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 14560 ug/kg/26W-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 30,1309,1996

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 2400 ug/kg/30D-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 30,1229,1996

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 11 mg/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 30,1341,1996

*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Acetic acid, fluoro-, calcium salt 63905-86-2
Acetic acid, ((4-nitrophenyl)thio)-, compd. with2-aminoethanol (1:1) 105892-18-0
Acetic acid, ((4-nitrophenyl)thio)-, compd. with2,2'-iminobis(ethanol) (1:1) 105892-19-1
Acetic acid, ((4-nitrophenyl)thio)-, compd. with2,2'',2'''-nitrilotris(ethanol) (1:1) 102582-90-1
Acetic acid, nitrosiminodi- 25081-31-6
Acetic acid, (N-nitrosoanilino)methyl ester 81943-37-5
Acetic acid, 2-(2-norbornylmethyl)hydrazide, oxalate(1:1) 81943-37-5
Acetic acid,(2-(octahydro-5-hydroxy-4-(3-hydroxy-5-methyl-1-nonenyl)-2-pentalenyl)etho xy)-, methyl ester,(2R-(2-alpha,3a-alpha,4-alpha(1E,3S*,5S*),5-beta,6a-alpha))- 139403-31-9
Acetic acid, octyl ester 112-14-1
Acetic acid, (3-(octyloxy)-2,4,6-triiodophenoxy)- 112-14-1
Acetic acid,oxo((7-oxo-1,3,5-cycloheptatrien-1-yl)amino)-, ethylester 65425-48-1
Acetic acid, fluoro-, (2-chloroethyl) ester 1537-62-8
Acetic acid, ((7-oxo-7H-benz(de)anthracen-3-yl)thio)- 69658-13-5
Acetic acid,((7-oxo-7H-benz(de)anthracen-3-yl)thio)-, ethyl ester 69658-14-6
Acetic acid,(2-((3-oxo-2(3H)-benzofuranylidene)methyl)phenoxy)- 70170-78-4
Acetic acid,(3-((3-oxo-2(3H)-benzofuranylidene)methyl)phenoxy)- 70170-89-7
Acetic acid,(4-((3-oxo-2(3H)-benzofuranylidene)methyl)phenoxy)- 70170-79-5
Acetic acid,2,2'-((9-oxo-9H-fluorene-2,7-diyl)bis(oxy))bis-,diheptyl ester 123278-14-8
Acetic acid,2,2'-((9-oxo-9H-fluorene-2,7-diyl)bis(oxy))bis-,dimethyl ester 123305-05-5
Acetic acid, oxo((4-(2-furanyl)-2-thiazolyl)amino)- 83089-59-2
Acetic acid, oxo((4-(2-furanyl)-2-thiazolyl)amino)-,ethyl ester 83089-58-1
Acetic acid,2-(o-((2-oxo-hexahydro-1H-azepin-3-ylidene)hydrazinyl)phenyl)- 66859-81-2
Acetic acid, fluoro-, copper(II) salt 20424-95-7
Acetic acid, oxo-, methyl ester 922-68-9
Acetic acid,(3-(2-oxomorpholino)-2,4,6-triiodophenoxy)phenyl-,sodium salt 21763-33-7
Acetic acid,(3-(3-oxomorpholino)-2,4,6-triiodophenyl)-, sodiumsalt 21838-47-1
Acetic acid,oxo((4-(((oxo((phenylmethyl)amino)acetyl)amino)sulfonyl)phenyl)amino)-, ethyl ester 81717-23-9
Acetic acid,((4-oxo-2-phenyl-4H-1-benzopyran-7-yl)oxy)-, ethylester 119-41-5
Acetic acid, (3-oxo-5-phenyl-2(3H)-furanylidene)-,ethyl ester 97181-01-6
Acetic acid, (3-oxo-5-phenyl-2(3H)-furanylidene)-,methyl ester 97180-95-5
Acetic acid, oxo((4-phenyl-2-thiazolyl)amino)-,2-ethoxyethyl ester 81529-70-6
Acetic acid, oxo((4-phenyl-2-thiazolyl)amino)-,2-(2-methoxyethoxy)ethyl ester 81529-71-7
Acetic acid, oxo((4-phenyl-2-thiazolyl)amino)-,2-methoxyethyl ester 81529-69-3
Acetic acid, fluoro-, dodecyl ester 81529-69-3
Acetic acid,(3-(2-oxopiperidino)-2,4,6-triiodophenoxy)phenyl-,sodium salt 21763-34-8
Acetic acid,2-(o-((2-oxo-3-piperidinylidene)hydrazinyl)phenyl)- 66953-62-6
Acetic acid,4-(2-oxo-5-(2-propynyloxymethyl-3-oxazolidinyl))phenyl- 43148-98-7
Acetic acid, oxo(4-pyrimidinylamino)-, ethyl ester 75274-22-5
Acetic acid,(3-(2-oxo-1-pyrrolidinyl)-2,4,6-triiodophenoxy)phenyl-, sodium salt 21761-96-6
Acetic acid,(3-(2-oxo-1-pyrrolidinyl)-2,4,6-triiodophenyl)-,sodium salt 21762-02-7
Acetic acid,((2-oxo-2-((tetrahydro-2-oxo-3-thienyl)amino)ethyl)thio)- 84611-23-4
Acetic acid,((2-oxo-3-(1H-tetrazol-5-yl)-2H-1-benzopyran-8-yl)oxy)- 103876-48-8
Acetic acid, oxo-((3-(1H-tetrazol-5-yl)phenyl)amino)- 114607-46-4
Acetic acid, oxo((3-(1H-tetrazol-5-yl)phenyl)amino)-,butyl ester 82989-25-1
Acetic acid, fluoro-, ethylene ester 372-77-0
Acetic acid, oxo((4-(2-thienyl)-2-thiazolyl)amino)- 83089-54-7
Acetic acid, oxo((4-(2-thienyl)-2-thiazolyl)amino)-,compd. with 2-aminoethanol (1:1) 83089-56-9
Acetic acid, oxo((4-(2-thienyl)-2-thiazolyl)amino)-,ethyl ester 83089-53-6
Acetic acid, oxo((4-(3-thienyl)-2-thiazolyl)amino)-,ethyl ester 83089-57-0
Acetic acid, oxo((4-(2-thienyl)-2-thiazolyl)amino)-,monosodium salt 83089-55-8

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